Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension

Autor: Kurt W. Prins, Rajat Kalra, Lauren Rose, Tufik R. Assad, Stephen L. Archer, Navkaranbir S. Bajaj, E. Kenneth Weir, Sasha Z. Prisco, Marc Pritzker, Pamela L. Lutsey, Evan L. Brittain, Thenappan Thenappan

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020)

Background Pulmonary arterial hypertension (PAH) is a lethal disease. In resource‐limited countries PAH outcomes are worse because therapy costs are prohibitive. To improve global outcomes, noninvasive and widely available biomarkers that identify

Externí odkaz: https://doaj.org/article/8e82535fe49747acb0b42fcc5f11da4a

Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension

Autor: Stephen J. Halliday, Meng Xu, Timothy E. Thayer, Jonathan D. Mosley, Quanhu Sheng, Fei Ye, Eric H. Farber-Eger, Meredith E. Pugh, Ivan R. Robbins, Tufik R. Assad, James D. West, Evan L. Brittain, Anna R. Hemnes

Publikováno v: Pulmonary Circulation, Vol 8 (2018)

Parenteral prostacyclin therapy is the most efficacious pharmacologic treatment for pulmonary arterial hypertension (PAH), but clinical response is variable. We sought to identify clinical, hemodynamic, and genetic associations with response to prost

Externí odkaz: https://doaj.org/article/a1d445a1829e4de68b19bd195af26586

Racial differences in patients referred for right heart catheterization and risk of pulmonary hypertension

Autor: Bin Q. Yang, Tufik R. Assad, Jared M. O'Leary, Meng Xu, Stephen J. Halliday, Reid W. D'Amico, Eric H. Farber-Eger, Quinn S. Wells, Anna R. Hemnes, Evan L. Brittain

Publikováno v: Pulmonary Circulation, Vol 8 (2018)

African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasian

Externí odkaz: https://doaj.org/article/43fa36ae57a14152abfaeac3f615f618

Abstract 16661: Fluid Challenge During Right Heart Catheterization for Evaluation of Pulmonary Hypertension Identifies Patients With Decreased Right Ventricular Function

Autor: Tufik R. Assad, Meredith E. Pugh, Anna R. Hemnes, Vineet A Agrawal, Ryan J Tedford, Amelia Muhs, John H. Newman, Vineet Agrawal, Evan L. Brittain, Ivan M. Robbins

Publikováno v: Circulation. 142

Introduction: Fluid challenge during right heart catheterization (RHC) identifies occult left heart diastolic dysfunction (Occ-DD) in 10-20% of patients initially diagnosed with pre-capillary pulmonary hypertension (PH). The prognostic implications o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::924b2e509d35db4bc7cffb071e782425
https://doi.org/10.1161/circ.142.suppl_3.16661

Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension

Autor: Christopher J. Rhodes, Anna Ulrich, William C. Nichols, Tufik R. Assad, Richard C. Trembath, Martin R. Wilkins, Lars Harbaum, Stefan Gräf, Marc Humbert, David-Alexandre Trégouët, John Wharton, Florent Soubrier, Ankit A. Desai, Nicholas W. Morrell, Inga Prokopenko, Emilia M. Swietlik, Evan L. Brittain, Laura Southgate, Timothy E. Thayer

Publikováno v: The European Respiratory Journal
European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2020, 55 (2), pp.1901486. ⟨10.1183/13993003.01486-2019⟩
European Respiratory Journal, 2020, 55 (2), pp.1901486. ⟨10.1183/13993003.01486-2019⟩

Pulmonary arterial hypertension (PAH) is a rare disease that leads to premature death from right heart failure. It is strongly associated with elevated red cell distribution width (RDW), a correlate of several iron status biomarkers. High RDW values

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f68215cca1569b0b16cadaf215507e6
http://hdl.handle.net/20.500.12278/26324