Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tuerdi Subati"'
Autor:
Tuerdi Subati, Zhenjiang Yang, Matthew B. Murphy, Joshua M. Stark, David Z. Trykall, Sean S. Davies, Joey V. Barnett, Katherine T. Murray
Publikováno v:
Cells, Vol 13, Iss 6, p 483 (2024)
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet the cellular and molecular mechanisms underlying the AF substrate remain unclear. Isolevuglandins (IsoLGs) are highly reactive lipid dicarbonyl products that mediate oxidat
Externí odkaz:
https://doaj.org/article/513c4d95dd3a462faa2c4beeed8678c4
Autor:
Zhenjiang Yang, Tuerdi Subati, Kyungsoo Kim, Matthew B. Murphy, Owen P. Dougherty, Isis L. Christopher, Joseph C. Van Amburg, Kaylen K. Woodall, Joey V. Barnett, Katherine T. Murray
Publikováno v:
Circ Arrhythm Electrophysiol
Background: With aging, the human atrium invariably develops amyloid composed of ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). Preamyloid oligomers are the primary cytotoxic species in amyloidosis, and they accumulate in the
Autor:
Kyungsoo Kim, Prince J. Kannankeril, Matthew B Murphy, Katherine T. Murray, Joey V. Barnett, Tuerdi Subati, Joseph C Van Amburg
Publikováno v:
Am J Physiol Heart Circ Physiol
Mice are routinely used to investigate molecular mechanisms underlying the atrial fibrillation (AF) substrate. We sought to optimize transesophageal rapid atrial pacing (RAP) protocols for the detection of AF susceptibility in mouse models. Hypertens
Autor:
Matthew Murphy, Zhenjiang Yang, Tuerdi Subati, Kaylen Woodall, Justin Van Beusecum, Charles Smart, Ashley Pitzer, Annet Kirabo, Meena Madhur, Joey Barnett, Dan M. Roden, Katherine T. Murray
Publikováno v:
Heart Rhythm. 19:S227
Autor:
Dan M. Roden, Prince J. Kannankeril, Annet Kirabo, Joshua M. Stark, Joseph C Van Amburg, Joey V. Barnett, Ashley Pitzer, Tuerdi Subati, Zhenjiang Yang, Isis L Christopher, Charles D Smart, Matthew B Murphy, Katherine T. Murray, Meena S. Madhur
Publikováno v:
Circulation. 142
Introduction: Inflammation and oxidative stress are linked to multiple risk factors for atrial fibrillation (AF), and to AF itself in the setting of sterile injury (e.g. after catheter ablation or cardiac surgery). However, anti-inflammatory therapie
Autor:
Matthew B Murphy, Joyce E. Johnson, Dan M. Roden, Isis L Christopher, Joey V. Barnett, Kyungsoo Kim, Joseph C Van Amburg, Katherine T. Murray, Tuerdi Subati
Publikováno v:
Circulation. 142
Introduction: The strongest genetic risk factor for atrial fibrillation (AF) is variants on chromosome 4q25, near the paired-like homeobox transcription factor 2 gene Pitx2 . Mice deficient in Pitx2 ( Pitx2 +/- ) have increased AF susceptibility, alt
Autor:
Sean S. Davies, Prince J. Kannankeril, Joshua M. Stark, James M. Luther, Annet Kirabo, Isis L Christopher, Meena S. Madhur, James B. Atkinson, Irene Zagol-Ikapitte, Liudmila V. Yermalitskaya, Scott R. Jafarian-Kerman, Matthew B Murphy, Agnes B. Fogo, David G. Harrison, Katherine T. Murray, Mohamed A. Saleh, Joey V. Barnett, Olivier Boutaud, Roxana Loperena, Joseph K. Prinsen, Venkataraman Amarnath, Tatiana N. Sidorova, Allison E. Norlander, Tuerdi Subati
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • IsoLGs are highly reactive lipid dicarbonyl metabolites that constitute a major component of oxidative stress-related injury, and they promote the formation of amyloid. • In a hypertensive murine model, IsoLG add
Highlights • IsoLGs are highly reactive lipid dicarbonyl metabolites that constitute a major component of oxidative stress-related injury, and they promote the formation of amyloid. • In a hypertensive murine model, IsoLG add