Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tue W, Kragstrup"'
Autor:
A. L. Hansen, L. S. J. Rahbek, A. S. Sørensen, M. P. Hundahl, S. Lomholt, C. K. Holm, Tue W. Kragstrup
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Inflammatory arthritis including rheumatoid arthritis (RA) and spondyloarthritis (SpA) is characterized by inflammation and destruction of the joints. Approximately one third of patients do not respond to first-line treatments. Ni
Externí odkaz:
https://doaj.org/article/72291e8e673b4103ab6f199ba94c62b2
Autor:
Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Kim Hørslev-Pedersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Malene Hvid, Søren K. Moestrup, Ellen Margrethe Hauge, Bent Deleuran
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThe programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA). Here, we investigated how membrane-bound and soluble (s)PD-1 influence bone h
Externí odkaz:
https://doaj.org/article/721728c51a5f41c1a23c8cb5c93f011d
Autor:
Morten A. Nielsen, Søren Lomholt, Anders Mellemkjær, Morten N. Andersen, Christopher D. Buckley, Tue W. Kragstrup
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 1, Pp 3-10 (2020)
Objective Immune‐mediated inflammatory arthritis (IMIA) is a heterogeneous group of diseases including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondyloarthritis (SpA). Disease‐modifying antirheumatic drugs (DMARDs) target very d
Externí odkaz:
https://doaj.org/article/30d61bae96b747abaa155a1c0b5d81fe
Autor:
Morten A. Nielsen, Ditte Køster, Akul Y. Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W. Kragstrup, Richard D. Cummings, Bent Deleuran
Publikováno v:
Cells, Vol 12, Iss 2, p 327 (2023)
Background: Fibroblast-like synoviocytes (FLSs) are essential mediators in the expansive growth and invasiveness of rheumatoid synovitis, and patients with a fibroblastic-rich pauci-immune pathotype respond poorly to currently approved antirheumatic
Externí odkaz:
https://doaj.org/article/7e2ff5101dc44835acefd2f61ffe6107
Autor:
Tue W. Kragstrup, Dong H. Sohn, Christin M. Lepus, Kazuhiro Onuma, Qian Wang, William H. Robinson, Jeremy Sokolove
Publikováno v:
BMC Rheumatology, Vol 3, Iss 1, Pp 1-8 (2019)
Abstract Background The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth factor beta (TGFβ)-induced myofibroblast production of extracellular ma
Externí odkaz:
https://doaj.org/article/a50a41d9eb314ea48a725fd4f7b270d3
Publikováno v:
BMC Rheumatology, Vol 2, Iss 1, Pp 1-9 (2018)
Abstract Background The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current treatment dampens inf
Externí odkaz:
https://doaj.org/article/5bb31c1d3c30416382801292118d010f
Autor:
Tue W Kragstrup, Helene Søgaard Singh, Ida Grundberg, Ane Langkilde-Lauesen Nielsen, Felice Rivellese, Arnav Mehta, Marcia B Goldberg, Michael R Filbin, Per Qvist, Bo Martin Bibby
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252799 (2021)
AimsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the infection termed coronavirus disease of 2019 (COVID-19). Here, we investigate a
Externí odkaz:
https://doaj.org/article/b73a665d101741b9a872983771202736
Autor:
Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Aida Solhøj Hansen, Akilan Krishnamurthy, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Midtbøll Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Lakshmanan Annamalai, Malene Hvid, Søren K. Moestrup, Ellen-Margrethe Hauge, Anca Irinel Catrina, Bent Deleuran
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100028- (2020)
Objective: Active rheumatoid arthritis (RA) is accompanied by increased appendicular and axial bone loss, closely associated to the degree of inflammation. The programmed death-1 (PD-1) pathway is important for maintaining peripheral tolerance, and i
Externí odkaz:
https://doaj.org/article/68abd7db88cb4b7db648af64688eedf5
Autor:
Tue W. Kragstrup, Mary Adams, Søren Lomholt, Morten A. Nielsen, Line D. Heftdal, Peter Schafer, Bent Deleuran
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 11 (2019)
Background: Apremilast (Otezla ® ) is a phosphodiesterase 4 (PDE4) inhibitor approved for the treatment of psoriasis and psoriatic arthritis (PsA), but the reason why apremilast shows clinical effect is not fully understood. The objective of this st
Externí odkaz:
https://doaj.org/article/368b57b5ad934c6887ac21b106b0b0ad
Autor:
Tue W. Kragstrup, Anne Sofie Sørensen, Mads Brüner, Søren Lomholt, Morten A Nielsen, Peter Schafer, Bent Deleuran
Publikováno v:
Kragstrup, T W, Sørensen, A S, Brüner, M, Lomholt, S, Nielsen, M A, Schafer, P & Deleuran, B 2022, ' MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2 ', International Immunopharmacology, vol. 112, 109267, pp. 109267 . https://doi.org/10.1016/j.intimp.2022.109267
Background: The development of novel treatment strategies of immune-mediated inflammatory arthritis (IMIA) is still a clinical unmet need. The mitogen-activated protein kinase (MAPK) pathway is activated by environmental stressors, growth factors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e54ab673193fa638c9316149fb2b88
https://pure.au.dk/portal/da/publications/mapk-activated-kinase-2-inhibition-shifts-the-chemokine-signature-in-arthritis-synovial-fluid-mononuclear-cells-from-cxcr3-to-cxcr2(e2c6ddf7-4075-4520-8be8-3cd04425cc32).html
https://pure.au.dk/portal/da/publications/mapk-activated-kinase-2-inhibition-shifts-the-chemokine-signature-in-arthritis-synovial-fluid-mononuclear-cells-from-cxcr3-to-cxcr2(e2c6ddf7-4075-4520-8be8-3cd04425cc32).html