Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tue H. Nguyen"'
Autor:
Boonsri Ongpipattanakul, Wyne P. Lee, L. Steven Beck, Rita L. Wong, Tue H. Nguyen, Leo Deguzman
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1379-1386
A 1.5 cm segmental defect in the radius of rabbits was used to compare healing at sites administered TGF-beta, with or without autologous bone marrow, to autogenous cortical bone graft. The carrier for TGF-beta consisted of tricalcium phosphate (TCP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d71e156df2c2323880030158745e58
https://doi.org/10.1021/js9800883
https://doi.org/10.1021/js9800883
Autor:
Rita L. Wong, Wyne P. Lee, Zioncheck Tf, Tue H. Nguyen, Beck Ls, Osaka G, Leo Deguzman, Boonsri Ongpipattanakul
Publikováno v:
Journal of Biomedical Materials Research. 36:295-305
Tricalcium phosphate (TCP) was combined with amylopectin to form a deliverable carrier paste for recombinant human transforming growth factor β1 (rhTGF-β1) intended for bone repair applications. Approximately 80% of rhTGF-β1 was released from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d70271ce4d6834e765cd421a2394f032
https://doi.org/10.1002/(sici)1097-4636(19970905)36:3<295::aid-jbm4>3.0.co
https://doi.org/10.1002/(sici)1097-4636(19970905)36:3<295::aid-jbm4>3.0.co
Publikováno v:
International Journal of Pharmaceutics. 142:85-95
Lyophilization is commonly used to dry protein pharmaceuticals to enhance their shelf life. During the freezing step of this process, significant events (e.g. pH shifting) can occur in the uncrystallized, liquid portion which influence the stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5396d5c89e9ec3bb1e3c774b52a596
https://doi.org/10.1016/0378-5173(96)04656-x
https://doi.org/10.1016/0378-5173(96)04656-x
Publikováno v:
Journal of Pharmaceutical Sciences. 85:868-872
Previously, our laboratory (Li, S.; et al. Biochemistry 1995, 34, 5762-5772) showed that the oxidation of recombinant human relaxin (Rix) could be induced by ascorbic acid (AsA)/Cu(II), a system used for the metal-catalyzed generation of reactive oxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab9c5e3b7eac195603a1c48ea73df99
https://doi.org/10.1021/js9504550
https://doi.org/10.1021/js9504550
Autor:
Tue Nguyen, J. Villagran, Zahra Shahrokh, Werner Rubas, Mrsny Randy J, Mary E.M. Cromwell, Tue H. Nguyen, M. Wellton
Publikováno v:
Journal of Pharmaceutical Sciences. 85:165-169
Confluent monolayers of Caco-2 cells, a human colonic carcinoma cell line, have been used extensively to predict intestinal absorption. A direct comparison of uptake characteristics, however, between cell monolayers and human tissue is missing in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffabc26f06dc301f5c6779fd8e7eb6ca
https://doi.org/10.1021/js950267+
https://doi.org/10.1021/js950267+
Publikováno v:
Pharmaceutical Research. 10:1563-1571
In this study, hydrogen peroxide was used to study the oxidation of rhRlx under various conditions. Oxidation of rhRlx occurred at both of the two methionines on the B chain, Met B(4) and Met B(25), as expected from the three-dimensional structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959c9cf2623905889bc23b06f4085260
https://doi.org/10.1023/a:1018908316698
https://doi.org/10.1023/a:1018908316698
Autor:
Steven J. Shire, Tue H. Nguyen
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9780306453328
Relaxin was discovered more than 50 years ago. However, only with the advent of recombinant DNA technology have sufficient amounts of human relaxin been produced and made available for in-depth biochemical characterization and pharmacological studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a21fb6a1b162ffa1db73c926ff01815a
https://doi.org/10.1007/0-306-47452-2_5
https://doi.org/10.1007/0-306-47452-2_5
Autor:
Ronald T. Borchardt, Tue H. Nguyen, Thomas W. Patapoff, Chung Hsu, Shihong Li, David E. Overcashier
Publikováno v:
Journal of pharmaceutical sciences. 85(8)
Sugars and polyols have been used routinely with lyophilized proteins and peptides as bulking agents, cryoprotectants, and lyoprotectants. However, reducing sugars may present a problem as excipients since they are potentially reactive with proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fc9eab923cf85ffc621f314ea6c7ea
https://pubmed.ncbi.nlm.nih.gov/8863280
https://pubmed.ncbi.nlm.nih.gov/8863280
Publikováno v:
Biochemistry. 34(17)
The interactions of proteins with reactive oxygen species may result in covalent modifications of amino acid residues in proteins and possible alterations of protein conformation. In an attempt to elucidate the mechanisms of the metal-catalyzed oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5d5060a4fd9f53b214a01f838ffe42
https://pubmed.ncbi.nlm.nih.gov/7727437
https://pubmed.ncbi.nlm.nih.gov/7727437
Autor:
Tue H. Nguyen
Publikováno v:
ACS Symposium Series ISBN: 9780841229594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73ccfbac161a2dad5d171cdcc5b0c4a5
https://doi.org/10.1021/bk-1994-0567.ch004
https://doi.org/10.1021/bk-1994-0567.ch004