Simulation Studies for the Evaluation of Health Information Technologies: Experiences and Results

Autor: Elske Ammenwerth, Kristine Binzer, Christian Nøhr, Sanne Jensen, Kitta Lawton, Peter Skjoet, Tue E. H. Christoffersen, Werner O. Hackl

Publikováno v: Scopus-Elsevier
Europe PubMed Central

It is essential for new health information technologies (IT) to undergo rigorous evaluations to ensure they are effective and safe for use in real-world situations. However, evaluation of new health IT is challenging, as field studies are often not f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c23175face622aa82395ab8cccff9
https://doi.org/10.1177/183335831204100202

Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy

Autor: Lars B. Nielsen, Søren P. Sheikh, Peter Kamp Busk, Tue E H Christoffersen, Stig Haunsø, Claes C. Strøm, Mark Aplin, Ole Skøtt

Publikováno v: Christoffersen, T E H, Aplin, M, Strom, C C, Sheikh, S P, Skøtt, O, Busk, P, Haunso, S & Nielsen, L B 2006, ' Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 290, no. 4, pp. H1635-H1641 . https://doi.org/10.1152/ajpheart.00612.2005

Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart. A putative clearance receptor, NPR-C, is believed to regulate cardiac level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a746bb041b637ec15e4a1d6341604fe9
https://doi.org/10.1152/ajpheart.00612.2005

Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy

Autor: Jiri Bartek, Peter Kamp Busk, Jirina Bartkova, Rebecca Hinrichsen, Stig Haunsø, Tue E H Christoffersen, Ane H Hansen

Publikováno v: Experimental Cell Research. 304:149-161

The myocytes of the adult mammalian heart are considered unable to divide. Instead, mitogens induce cardiomyocyte hypertrophy. We have investigated the effect of adenoviral overexpression of cyclin D2 on myocyte proliferation and morphology. Cardiomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad79724e5b5d10e882016a03e1c2fea
https://doi.org/10.1016/j.yexcr.2004.10.022

Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart

Autor: Tue E H Christoffersen, Jens R. Nyengaard, Annemarie Brüel

Publikováno v: Brüel, A, Christoffersen, T E H & Nyengaard, J R 2008, ' Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart ', Cardiovascular Research, vol. 79, no. 3, pp. 400-8 . https://doi.org/10.1016/j.cardiores.2007.06.026

Udgivelsesdato: 2008-Aug-1 OBJECTIVE: Growth hormone (GH) is known to induce growth of the normal rat heart. Whether this growth is due solely to hypertrophy of the cardiac myocytes or whether a concomitant hyperplasia of the cardiac myocytes also ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c471264d88cf7ef9b994987ea632ba9
https://pure.au.dk/portal/da/publications/growth-hormone-increases-the-proliferation-of-existing-cardiac-myocytes-and-the-total-number-of-cardiac-myocytes-in-the-rat-heart(7ea262d0-fce3-11dd-a987-000ea68e967b).html