Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tudor Arvinte"'
Autor:
Amelia Cudd, Tudor Arvinte, Jason Dowd, Caroline Palais, Shanthi Rajendran, Stephen Brokx, Emilie Poirier
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 176
The physicochemical properties of Avastin® manufactured in the USA (Originator USA) and in Europe (Originator EU) and ABX-BEV, a bevacizumab biosimilar drug product candidate produced by Apobiologix Inc., were characterized at a clinically relevant
Autor:
Jason Dowd, Stephen Brokx, Amelia Cudd, Emilie Poirier, Shanthi Rajendran, Tudor Arvinte, Caroline Palais
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 175
The biosimilarity assessment of the physicochemical properties of high-concentration biopharmaceuticals is usually performed with measurements on diluted solutions, at concentrations below 1 mg/mL. In this study 13 orthogonal, spectroscopy and partic
Biological products are an important part of medical treatment and comprise a wide range of materials such as purified human blood components (e.g. albumin, immunoglobulins), vaccines, cell therapies or recombinant therapeutic proteins. The terms bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f0abc1b63a344ec078087f4c25a57c1
https://doi.org/10.1039/9781782620402-00288
https://doi.org/10.1039/9781782620402-00288
Publikováno v:
Journal of Pharmaceutical Sciences. 104:612-617
Asymmetrical flow field-flow fractionation (afFFF) was used to investigate the properties of a plant-produced anthrax toxin protective antigen, pp-PA83. The afFFF fractogram consisted of two main peaks with molar masses similar to the molecular mass
Autor:
Camilla, De Nardis, Linda J A, Hendriks, Emilie, Poirier, Tudor, Arvinte, Piet, Gros, Alexander B H, Bakker, John, de Kruif
Publikováno v:
The Journal of biological chemistry. 292(35)
Bispecific antibodies show great promise as intrinsic combination therapies, but often suffer from poor physiochemical properties, many times related to poor heterodimerization. De Nardis et al. identify specific electrostatic interactions that facil
Publikováno v:
mAbs. 5:162-170
Automation robots have recently come to the market as an alternative for manual compounding of drugs for intravenous administration. Our aim was to assess whether robotic compounding can be performed with monoclonal antibodies (mAbs) without influenc
Publikováno v:
Journal of Drug Delivery Science and Technology. 22:427-433
Nanoparticle tracking analysis (NTA) is a relatively new technique for the size characterization of particles between 40 and 1000 nm. Recent studies have shown an increasing interest in NTA as a complementary technique in the field of pharmaceutical
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 79:646-657
Protein aggregation, which is triggered by various factors, is still one of the most prevalent problems encountered during all stages of protein formulation development. In this publication, we present novel excipients, tryptophan-mPEGs (Trp-mPEGs) o
Publikováno v:
Vaccine. 29:7404-7413
The stability of different seasonal influenza vaccines was investigated by spectroscopy and microscopy methods before and after the following stress-conditions: (i) 2 and 4 weeks storage at 25°C, (ii) 1 day storage at 37°C and (iii) one freeze-thaw
Autor:
Tudor Arvinte, Henryk Mach
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 78:196-207
As the share of therapeutic proteins in the arsenal of modern medicine continue increasing, relatively little progress has been made in the development of analytical methods that would address specific needs encountered during the development of thes