Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection.

Autor: Hammers DE; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States., Donahue DL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Tucker ZD; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Ashfeld BL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Ploplis VA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Castellino FJ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Lee SW; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Nov 01; Vol. 12, pp. 1002230. Date of Electronic Publication: 2022 Nov 01 (Print Publication: 2022).

Rational Design and Identification of Harmine-Inspired, N-Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System.

Autor: Huizar FJ; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Hill HM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Bacher EP; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Eckert KE; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Gulotty EM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Rodriguez KX; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Tucker ZD; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Banerjee M; Warren Family Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN 46556, USA., Liu H; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA., Wiest O; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.; Warren Family Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN 46556, USA., Zartman J; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Ashfeld BL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.; Warren Family Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN 46556, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2022 Feb 16; Vol. 17 (4), pp. e202100512. Date of Electronic Publication: 2022 Jan 27.

Diverting β-Hydride Elimination of a π-Allyl Pd ^II Carbene Complex for the Assembly of Disubstituted Indolines via a Highly Diastereoselective (4 + 1)-Cycloaddition.

Autor: Tucker ZD; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States., Hill HM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States., Smith AL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States., Ashfeld BL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.

Publikováno v: Organic letters [Org Lett] 2020 Aug 21; Vol. 22 (16), pp. 6605-6609. Date of Electronic Publication: 2020 Aug 12.