Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Tubulin deacetylation"'
Autor:
Akira Kubo, Haruka Sudo
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9397, p 9397 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9397, p 9397 (2021)
Diabetes mellitus (DM) is considered to be associated with an increased risk of colorectal cancer. Recent studies have also revealed that tubulin hyperacetylation is caused by a diabetic status and we have reported previously that, under microtubule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb2926a0934e7471897dcdc0db6dfbb
Autor:
Tomohiro Kawamoto, Michiko Terada, Sho Sato, Ryouta Maeda, Maiko Tanaka, Tomohiro Onishi, Kentaro Hashikami, Takahiro Fujii, Masahiro Ito
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies. Tau pathology is associated with axonal degen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430b2344366f412da756a5051edff34e
https://doi.org/10.1038/s41598-021-94923-w
https://doi.org/10.1038/s41598-021-94923-w
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
The Golgi apparatus (GA) is a pivotal organelle, and its fragmentation is an essential process in the development of apoptosis. GA is a potential target in the treatment of cerebral ischemia-reperfusion injury. Histone deacetylase 6 (HDAC6) catalyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a30e0768234b7e8557bc6ee36dcd66a
https://doi.org/10.1155/2019/6507537
https://doi.org/10.1155/2019/6507537
Autor:
Kemal Yelekçi, Abdullahi Ibrahim Uba
Publikováno v:
Computational Biology and Chemistry. 77:318-330
Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of the current HDAC6 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5e90cb4deff9d72b0b2777aa616388
https://doi.org/10.1016/j.compbiolchem.2018.10.016
https://doi.org/10.1016/j.compbiolchem.2018.10.016
SummarySETDB1 is a methyltransferase responsible for the methylation of histone H3-lysine-9, which is mainly related to heterochromatin formation. SETDB1 is overexpressed in various cancer types and is associated with an aggressive phenotype. In agre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26911f1d7915931253e6f08673a9e0f3
https://doi.org/10.1101/2021.05.15.444210
https://doi.org/10.1101/2021.05.15.444210
Publikováno v:
International Journal of Molecular Medicine
Matrix metalloproteinase (MMP)-9 is a key enzyme responsible for extracellular matrix degradation and contributes to the progressive histological changes observed in lower respiratory tract infections. Integrin β1 and α-tubulin are potential MMP-9-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ef1a0e1f688505a33db0850e432fdb
https://doi.org/10.3892/ijmm.2021.4959
https://doi.org/10.3892/ijmm.2021.4959
Autor:
Nuri Gueven, Rameshwor Acharya, Frederick M. Pfeffer, Kyle N Hearn, Trent D. Ashton, Zikai Feng
Publikováno v:
Cells
Volume 10
Issue 6
Cells, Vol 10, Iss 1505, p 1505 (2021)
Volume 10
Issue 6
Cells, Vol 10, Iss 1505, p 1505 (2021)
Methodology to access fluorescent 3-amido-1,8-naphthalimides using direct Buchwald–Hartwig amidation is described. The protocol was successfully used to couple a number of substrates (including an alkylamide, an arylamide, a lactam and a carbamate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf329717196a417fb560ba1f35559be3
https://pubmed.ncbi.nlm.nih.gov/34203745
https://pubmed.ncbi.nlm.nih.gov/34203745
Publikováno v:
Biochemical and biophysical research communications. 544
Cobalt ions are the main wear particles associated with orthopaedic implants, causing adverse complications due to cytotoxicity and inflammatory mediators. Recent studies have shown that sub-toxic levels of cobalt ions regulate matrix synthesis and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1259136a18b7dee805aac90a95a84a8
https://pubmed.ncbi.nlm.nih.gov/33867123
https://pubmed.ncbi.nlm.nih.gov/33867123
Publikováno v:
Oncogene. 40(12)
Progression of triple-negative breast cancer (TNBC) constitutes a major unresolved clinical challenge, and effective targeted therapies are lacking. Because microtubule dynamics play pivotal roles in breast cancer metastasis, we performed RNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c62a93c9a8eb9c65b5f386abaf2be
https://pubmed.ncbi.nlm.nih.gov/33654196
https://pubmed.ncbi.nlm.nih.gov/33654196
Autor:
Kseniya Ustinova, Zora Novakova, Mike Schutkowski, Patrick Matthias, Zsofia Kutil, Makoto Saito, Barbora Havlinova, Cyril Barinka, Marat Meleshin, Jana Mikešová, Petra Baranova
Publikováno v:
J Biol Chem
Histone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase activity that has been unequivocally assigned to the second of the tandem catalytic domains. However, virtually no information exists on the contribution of ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f86b171dbfbb0298956472ff6978878
https://europepmc.org/articles/PMC7049964/
https://europepmc.org/articles/PMC7049964/