Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Tubulin Binding Agent"'
Akademický článek
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Akademický článek
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Autor:
Ralph P. Mason, Jeni Gerberich, Yihang Guo, Honghong Wang, Li Liu, Amanda K. Charlton-Sevcik, Justin K. Tidmore, Maoping Li, Samuel O. Odutola, Kevin G. Pinney, Mary Lynn Trawick, Rajendra P. Tanpure
Publikováno v:
Cancers
Volume 13
Issue 19
Cancers, Vol 13, Iss 4769, p 4769 (2021)
Volume 13
Issue 19
Cancers, Vol 13, Iss 4769, p 4769 (2021)
Simple Summary Vascular-disrupting agents promise significant therapeutic efficacy against solid tumors by selectively damaging tumor-associated vasculature. Dynamic BLI and oxygen-enhanced multispectral optoacoustic tomography (OE-MSOT) were used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ca796415a404dbe9c22f8440cbbb60
Publikováno v:
Investigational New Drugs. 37:784-790
Liver cancer is a kind of high mortality cancer due to the difficulty of early diagnosis. It is necessary to develop the anticancer agents to treat liver cancer. Here, a novel chalcone derivative was synthesized and evaluated for anticancer activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06bd23bb28e8ec37307fdb2a6da5f7e
https://doi.org/10.1007/s10637-019-00737-z
https://doi.org/10.1007/s10637-019-00737-z
Autor:
Li Liu, Regan Schuetze, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Devin O’Kelly, Graham J. Carlson, Heling Zhou
Publikováno v:
Molecules, Vol 26, Iss 2551, p 2551 (2021)
Molecules
Molecules
Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely frag-ile making it an attractive therapeutic target. A subset of small-molecule tubulin binding agents cause disaggregation of the endothelial cytoskeleton lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb27d9b46b021d647526f14c1f412d38
Autor:
Karthikeyan Jayabalan, Janet Sabina Xavier, A. Nityananda Shetty, V. Ragavendran, Muthu Tamizh Manoharan
Publikováno v:
Bioorganic chemistry. 114
Microtubule targeting agents that disrupt the dynamic functioning of the mitotic spindle are some of the best chemotherapeutic agents. Interruption of microtubule dynamics through polymerization or depolymerization causes cell arrest leading to apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0997be30622aa8ed0376107c73745
https://pubmed.ncbi.nlm.nih.gov/34167017
https://pubmed.ncbi.nlm.nih.gov/34167017
Autor:
Dmitry V. Demchuk, Alexander E. Varakutin, Anna S. Maksimenko, Alex S. Kiselyov, N. B. Chernysheva, Marina N. Semenova, V. P. Kislyi, Leonid D. Konyushkin, Eugenia A. Silyanova, Mikhail M. Raihstat, Victor V. Semenov, Dmitry V. Tsyganov, Alexander V. Samet
Publikováno v:
ACS Combinatorial Science. 20:700-721
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea urchin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9201a126c9cf575c8c1bfb403f8a709
https://doi.org/10.1021/acscombsci.8b00113
https://doi.org/10.1021/acscombsci.8b00113
Publikováno v:
Russian Journal of General Chemistry. 88:2183-2189
A novel series of tetrazole fused benzoxazole derivatives 9a–9j are synthesized, and their structures are characterized by 1H and 13C NMR, and mass spectra. The compounds 9a, 9b, 9g, 9h, and 9j demonstrate the highest activity. The compounds 9b and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccace86e0b0771d58ec64c051cd65d3
https://doi.org/10.1134/s1070363218100250
https://doi.org/10.1134/s1070363218100250
Autor:
Galmarini, Carlos M, Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo, Sub Cell Biology, Celbiologie
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Cancer
BMC Cancer, 18(1). BioMed Central
BMC cancer, 18 (1
BMC Cancer
BMC Cancer, 18(1). BioMed Central
BMC cancer, 18 (1
Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities.
info:eu-repo/s
info:eu-repo/s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f467481f65bafbc70105e2a89bcdca
http://link.springer.com/article/10.1186/s12885-018-4086-2
http://link.springer.com/article/10.1186/s12885-018-4086-2
Autor:
Koji Ando, Yuichiro Nakashima, Ryota Nakanishi, Yoshihiko Maehara, Yasuo Tsuda, Eiji Oki, Hiroyuki Kitao, Hiroshi Saeki, Makoto Iimori, Kippei Ohgaki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Tubulin-binding agents (TBAs) are designed to target microtubule (MT) dynamics, resulting in compromised mitotic spindles and an unsatisfied spindle assembly checkpoint. The activity of Aurora B kinase is indispensable for TBA-induced mitotic arrest,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c6bb81eed04dbf20a930f7d67696d6
http://link.springer.com/article/10.1038/s41598-017-17002-z
http://link.springer.com/article/10.1038/s41598-017-17002-z