Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Tuba N. Gide"'
Autor:
Xinyu Bai, Grace H. Attrill, Tuba N. Gide, Peter M. Ferguson, Kazi J. Nahar, Ping Shang, Ismael A. Vergara, Umaimainthan Palendira, Ines Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott, Camelia Quek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are incompletely understood. Here, we characterize the immunogenomic profile and spatial archi
Externí odkaz:
https://doaj.org/article/4e3968539ed44b5d8e921475912375ae
Autor:
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTLymphocyte-activation gene-3 (LAG-3), an immune checkpoint receptor, negatively regulates T-cell function and facilitates immune escape of tumors. Dual inhibition of LAG-3 and programmed cell death receptor-1 (PD-1) significantly improved pro
Externí odkaz:
https://doaj.org/article/de51474a80d24f65bee9d63be6c7447f
Autor:
Yizhe Mao, Tuba N. Gide, Nurudeen A. Adegoke, Camelia Quek, Nigel Maher, Alison Potter, Ellis Patrick, Robyn P. M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Matteo S. Carlino, Serigne N. Lo, Alexander M. Menzies, Inês Pires da Silva, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Gene expression profiling is increasingly being utilised as a diagnostic, prognostic and predictive tool for managing cancer patients. Single-sample scoring approach has been developed to alleviate instability of signature scores
Externí odkaz:
https://doaj.org/article/ef7110af153c44aabefb4fbcf176e3ad
Autor:
Kazi J. Nahar, Felix Marsh-Wakefield, Robert V. Rawson, Tuba N. Gide, Angela L. Ferguson, Ruth Allen, Camelia Quek, Ines Pires da Silva, Stephen Tattersal, Christopher J. Kiely, Neomal Sandanayake, Matteo S. Carlino, Geoff McCaughan, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Alexander M. Menzies, Umaimainthan Palendira
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Immune-related adverse events represent a major hurdle to the success of immunotherapy. The immunological mechanisms underlying their development and relation to antitumor responses are poorly understood. By examining both systemic and tissue-specifi
Externí odkaz:
https://doaj.org/article/3735f33fbccb4897a34d7c5e7b464466
Autor:
Zarwa Yaseen, Tuba N. Gide, Jordan W. Conway, Alison J. Potter, Camelia Quek, Angela M. Hong, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Multiplex immunofluorescence staining enables the simultaneous detection of multiple immune markers in a single tissue section, and is a useful tool for the identification of specific cell populations within the tumour microenvironment. However, this
Externí odkaz:
https://doaj.org/article/981eb8190d6b4c0d884849cb1fb0858b
Autor:
Tuba N. Gide, Ines P. Silva, Camelia Quek, Tasnia Ahmed, Alexander M. Menzies, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Marcel Batten, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immune checkpoint blockade has greatly improved the clinical outcomes of many patients with metastatic melanoma, however, almost half do not respond. Whether the interspatial distribution of immune and tumor cells predicts response to anti-PD-1-based
Externí odkaz:
https://doaj.org/article/908395d43615467e961ccc319c2ee102
Autor:
Rehana A Salam, Tuba N Gide, Anne E Cust, Richard A Scolyer, Georgina V Long, Ines P da Silva, Peter Ferguson, Graham J Mann, Caroline Watts, James S Wilmott, Andrea L Smith
Background Immunotherapies have significantly improved the overall survival for patients with advanced melanoma. However, almost half of such patients either do not respond to the therapy or develop resistance to it, subjecting patients to ineffectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636efc6af3a1d6b29fdae5cae00f708e
https://doi.org/10.21203/rs.3.rs-2844230/v1
https://doi.org/10.21203/rs.3.rs-2844230/v1
Autor:
Jennifer L. McQuade, Yana G. Najjar, Greg M. Delgoffe, Michael A. Davies, Weiyi Peng, James S. Wilmott, Jianhua Zhang, Andrew Futreal, Han Liang, Ralph J. DeBerardinis, John M. Kirkwood, Jennifer A. Wargo, Dirk Schadendorf, Alexander J. Lazar, Michael T. Tetzlaff, Richard A. Scolyer, Georgina V. Long, Jeffrey E. Gershenwald, Nadim Ajami, Patrick Hwu, Jeffrey E. Lee, John F. Thompson, Khalida M. Wani, Jian Wang, Grant M. Fischer, Renato Guerrieri, Y.N. Vashisht Gopal, Scott E. Woodman, Nagireddy Putluri, Chantale Bernatchez, Julie M. Simon, Jared Malke, Elizabeth M. Burton, Vancheswaran Gopalakrishnan, M.A. Wadud Khan, Lauren E. Haydu, Theodore Nowicki, Courtney W. Hudgens, Carrie R. Daniel, Alexander M. Menzies, Christine N. Spencer, Yan Zang, Camelia Quek, Tuba N. Gide, Aditya K. Mishra, Xiaogang Wu, Jun Li, Mingchu Xu, Ryan C. Augustin, Dayana B. Rivadeneira, Ashley V. Menk, Andrew W. Hahn
Supplementary Table 1: Baseline characteristics for patients included in the integrated gene set enrichment analysis (Figure 2-3) by cohort; Supplementary Table 6: The most frequent somatic alterations (alts) in patients with regionally metastatic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e0d286392da9de64a5ae2a2632417b
https://doi.org/10.1158/1078-0432.22488729.v1
https://doi.org/10.1158/1078-0432.22488729.v1
Autor:
Jennifer L. McQuade, Yana G. Najjar, Greg M. Delgoffe, Michael A. Davies, Weiyi Peng, James S. Wilmott, Jianhua Zhang, Andrew Futreal, Han Liang, Ralph J. DeBerardinis, John M. Kirkwood, Jennifer A. Wargo, Dirk Schadendorf, Alexander J. Lazar, Michael T. Tetzlaff, Richard A. Scolyer, Georgina V. Long, Jeffrey E. Gershenwald, Nadim Ajami, Patrick Hwu, Jeffrey E. Lee, John F. Thompson, Khalida M. Wani, Jian Wang, Grant M. Fischer, Renato Guerrieri, Y.N. Vashisht Gopal, Scott E. Woodman, Nagireddy Putluri, Chantale Bernatchez, Julie M. Simon, Jared Malke, Elizabeth M. Burton, Vancheswaran Gopalakrishnan, M.A. Wadud Khan, Lauren E. Haydu, Theodore Nowicki, Courtney W. Hudgens, Carrie R. Daniel, Alexander M. Menzies, Christine N. Spencer, Yan Zang, Camelia Quek, Tuba N. Gide, Aditya K. Mishra, Xiaogang Wu, Jun Li, Mingchu Xu, Ryan C. Augustin, Dayana B. Rivadeneira, Ashley V. Menk, Andrew W. Hahn
Integrated gene set enrichment analysis by body mass index (BMI) with correction for S phase. This figure presents a dotplot of genes differentially up- or downregulated in OW/OB patients versus NL BMI patients. Red indicates upregulation in OW/OB ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e1234608e81d53bb5fc98e6222af62
https://doi.org/10.1158/1078-0432.22488771.v1
https://doi.org/10.1158/1078-0432.22488771.v1
Autor:
Jennifer L. McQuade, Yana G. Najjar, Greg M. Delgoffe, Michael A. Davies, Weiyi Peng, James S. Wilmott, Jianhua Zhang, Andrew Futreal, Han Liang, Ralph J. DeBerardinis, John M. Kirkwood, Jennifer A. Wargo, Dirk Schadendorf, Alexander J. Lazar, Michael T. Tetzlaff, Richard A. Scolyer, Georgina V. Long, Jeffrey E. Gershenwald, Nadim Ajami, Patrick Hwu, Jeffrey E. Lee, John F. Thompson, Khalida M. Wani, Jian Wang, Grant M. Fischer, Renato Guerrieri, Y.N. Vashisht Gopal, Scott E. Woodman, Nagireddy Putluri, Chantale Bernatchez, Julie M. Simon, Jared Malke, Elizabeth M. Burton, Vancheswaran Gopalakrishnan, M.A. Wadud Khan, Lauren E. Haydu, Theodore Nowicki, Courtney W. Hudgens, Carrie R. Daniel, Alexander M. Menzies, Christine N. Spencer, Yan Zang, Camelia Quek, Tuba N. Gide, Aditya K. Mishra, Xiaogang Wu, Jun Li, Mingchu Xu, Ryan C. Augustin, Dayana B. Rivadeneira, Ashley V. Menk, Andrew W. Hahn
Differential gene expression analysis for each subgroup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca30a8a74ec42000707d150324a618be
https://doi.org/10.1158/1078-0432.22488738
https://doi.org/10.1158/1078-0432.22488738