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pro vyhledávání: '"Tuanny L Almeida"'
Autor:
Tuanny L Almeida, Timothy M. Willson, Álvaro Lorente-Macías, William J. Zuercher, Reena Zutshi, David H. Drewry, Jonathan M. Elkins, Carrow I. Wells, Cunyu Zhang, Julie E. Pickett, Juanita C. Limas, Opher Gileadi, Alexander Riemen, Alison D. Axtman, Jeanette Gowen Cook, Roberta R. Ruela-de-Sousa, Nirav Kapadia, Rafael M. Couñago
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over