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pro vyhledávání: '"Tuan-Anh M. Nguyen"'
Autor:
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension. Despite thei
Externí odkaz:
https://doaj.org/article/0122f565b7344705acbec756a7913021
Autor:
Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-7 (2021)
Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated deriva
Externí odkaz:
https://doaj.org/article/a4636663e9554be2a14b9b29affc4904