Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Tuan Zea, Tan"'
Autor:
Sinan Xiong, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Tuan Zea Tan, Sabrina Hui-Min Toh, Nicole Xin Ning Tang, Yunlu Jia, Yi Xiang See, Melissa Jane Fullwood, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. Her
Externí odkaz:
https://doaj.org/article/a72d588788c3426aa48efeac9ff0d625
Autor:
Xianning Lai, Sarah Kit Leng Lui, Hiu Yan Lam, Yuta Adachi, Wen Jing Sim, Natali Vasilevski, Nicola J. Armstrong, Stephanie Claire Bridgeman, Nathan Michael Main, Tuan Zea Tan, Janina E. E. Tirnitz-Parker, Jean Paul Thiery, Hiromichi Ebi, Alan Prem Kumar, Pieter Johan Adam Eichhorn
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window. Like with all MAPK pathway inhibitors, this is likely the result of compensatory pa
Externí odkaz:
https://doaj.org/article/375510663f6147c1abe8dec01b58fcb1
Autor:
Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Kai Lay Esther Peh, Yi-Chia Chiu, Tuan Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam, Ruby Yun-Ju Huang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-6 (2023)
Externí odkaz:
https://doaj.org/article/4669c9aed0f141f9b131ea498542c898
Autor:
Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Kai Lay Esther Peh, Yi-Chia Chiu, Tuan Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam, Ruby Yun-Ju Huang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance, making it an emerging therapeutic target. The first-in-class AXL inhibitor bemcenti
Externí odkaz:
https://doaj.org/article/e4c51514b6d442e4b1c53e454bfbf0d3
Autor:
Jianbiao Zhou, Sabrina Hui-Min Toh, Tze King Tan, Kalpnaa Balan, Jing Quan Lim, Tuan Zea Tan, Sinan Xiong, Yunlu Jia, Siok-Bian Ng, Yanfen Peng, Anand D. Jeyasekharan, Shuangyi Fan, Soon Thye Lim, Chin-Ann Johnny Ong, Choon Kiat Ong, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background Extranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding of disease biology and key oncogenic process is necessary for the development of targeted t
Externí odkaz:
https://doaj.org/article/846e95d9de9a442a8d6a7330386245b8
Autor:
Xue Ting Tan, Daniel BL Teh, Lang-Chu Lau, Weiling Eunice Sim, Jovin Lee, Richard Tang, Jonathan Lee, Jin-Young Lee, Shuo Deng, Celestial Theresa Yap, Tuan Zea Tan, Wei Yi Ong, Feng Pan, Xing Fei Tan, George W. Yip, Zhongwei Huang
Publikováno v:
Fertility & Reproduction, Vol 05, Iss 04, Pp 576-576 (2023)
Background and Aims: The mTORC1 pathway is known to play a critical role in longevity and is a central regulator for various pathways including cellular, inflammation, and metabolic pathways. Age-related functional decline in tissue was associated wi
Externí odkaz:
https://doaj.org/article/2aceb0a2b591481698517ec891e7fc60
Autor:
Jean Agnetti, Vanessa Bou Malham, Christophe Desterke, Nassima Benzoubir, Juan Peng, Sophie Jacques, Souad Rahmouni, Emanuel Di Valentin, Tuan Zea Tan, Didier Samuel, Jean Paul Thiery, Ama Gassama-Diagne
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Overexpression of isoform δ of phosphoinositide 3-kinase (PI3Kδ) promotes stemness in hepatocellular carcinoma cell lines and mouse liver, whereas its inhibition promotes EMT, suggesting a key role for PI3Kδ in epithelial plasticity.
Externí odkaz:
https://doaj.org/article/b4d2124ccf174f3b8ca36dab0e6b9aba
Autor:
Qing You Pang, Tuan Zea Tan, Vignesh Sundararajan, Yi-Chia Chiu, Edward Yu Wing Chee, Vin Yee Chung, Mahesh A. Choolani, Ruby Yun-Ju Huang
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-31 (2022)
Abstract Background The plasticity along the epithelial-mesenchymal transition (EMT) spectrum has been shown to be regulated by various epigenetic repertoires. Emerging evidence of local chromatin conformation changes suggests that regulation of EMT
Externí odkaz:
https://doaj.org/article/724cb006a5314591b4fd1dcd91a52103
Autor:
Wijaya, Silvana Talisa, Ngoi, Natalie Y. L., Loh, Jerold W. Z., Tuan Zea Tan, Lim, Diana, Khan, Irfan Sagir, Yee Liang Thian, Lai, Alexa, Ang, Bertrand W. L., Tong, Pearl, Ng, Joseph, Low, Jeffrey J. H., Ilancheran, Arunachalam, Siew Eng Lim, Yi Wan Lim, Tan, David S. P.
Publikováno v:
Journal of Gynecologic Oncology; Sep2024, Vol. 35 Issue 5, p1-15, 15p
Autor:
Ser Yue Loo, Nicholas L. Syn, Angele Pei-Fern Koh, Janet Cheng-Fei Teng, Amudha Deivasigamani, Tuan Zea Tan, Aye Aye Thike, Shireen Vali, Shweta Kapoor, Xiaoyuan Wang, Jiong Wei Wang, Puay Hoon Tan, George W. Yip, Gautam Sethi, Ruby Yun-Ju Huang, Kam Man Hui, Lingzhi Wang, Boon Cher Goh, Alan Prem Kumar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Clinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a variety of tumor types. Here, we report that increased PPARG expression is associ
Externí odkaz:
https://doaj.org/article/82fb2ea92fce4d45b46ee3f019c45a37