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Akademický článek

Molecular characterization of breast cancer CTCs associated with brain metastasis

Autor: Debasish Boral, Monika Vishnoi, Haowen N. Liu, Wei Yin, Marc L. Sprouse, Antonio Scamardo, David S. Hong, Tuan Z. Tan, Jean P. Thiery, Jenny C. Chang, Dario Marchetti

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Characterization of CTCs derived from breast cancer patients with brain metastasis (BCBM) may allow for early diagnosis of brain metastasis and/or help for treatment choice and its efficacy. In this study, the authors identify a unique signature, bas

Externí odkaz: https://doaj.org/article/924c0ac03d9d404c931127a48b58fb79

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Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Metastatic breast cancer is still incurable so far; new specifically targeted and more effective therapies for triple-negative breast cancer (TNBC) are required in the clinic. In this study, our clinical data have established that basal and claudin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a0c0e006c3abbabd69d14315bda93e
https://doi.org/10.1158/1535-7163.c.6539263.v1

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Supplementary Figure 1 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 1: High ANXA1 and PPARγ expression levels positively correlates with the invasive, high-grade phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a52bb0d216b583547635ad48b7918
https://doi.org/10.1158/1535-7163.22509319

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Supplementary Figure 2 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 2: ANXA1 expressing TNBC cell lines display greater sensitivity to PPARγ ligands compared to ANXA1 depleted cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48392110051076c68f80b12a3c9855ed
https://doi.org/10.1158/1535-7163.22509316

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Supplemental Data from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary methods and supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6963a538aeeeffe32e7e217be5f31
https://doi.org/10.1158/1535-7163.22509322.v1

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Supplementary Figure 3 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 3: PPARγ induced expression of ANXA1 and cell death is abrogated in TNBC cells with pre-incubation of a PPARγ-specific antagonist or use of a dominant negative derivative of PPARγ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f8a276b53f71a91851a1a8a4f6ab9
https://doi.org/10.1158/1535-7163.22509313.v1

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Supplementary Figure 4 from PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

Supplementary Figure 4: PPARγ ligand-induced changes in expression of RIP1 and NEMO and therefore NFκB activity are receptor dependent.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9325507dd54cc45444196a0bdeaf
https://doi.org/10.1158/1535-7163.22509310

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Akademický článek

Measurement of fetal fraction in cell-free DNA from maternal plasma using a panel of insertion/deletion polymorphisms.

Autor: Angela N Barrett, Li Xiong, Tuan Z Tan, Henna V Advani, Rui Hua, Cecille Laureano-Asibal, Richie Soong, Arijit Biswas, Niranjan Nagarajan, Mahesh Choolani

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186771 (2017)

OBJECTIVE:Cell-free DNA from maternal plasma can be used for non-invasive prenatal testing for aneuploidies and single gene disorders, and also has applications as a biomarker for monitoring high-risk pregnancies, such as those at risk of pre-eclamps

Externí odkaz: https://doaj.org/article/32721a1e68784c72873019b71f5d9181

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'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling

Autor: Mei S, Ong, Wanpei, Cai, Yi, Yuan, Hin C, Leong, Tuan Z, Tan, Asad, Mohammad, Ming L, You, Frank, Arfuso, Boon C, Goh, Sudha, Warrier, Gautam, Sethi, Nicholas S, Tolwinski, Peter E, Lobie, Celestial T, Yap, Shing C, Hooi, Ruby Y, Huang, Alan P, Kumar

Publikováno v: British journal of pharmacology. 174(24)

Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs and long non-coding RNAs (l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::727f07ab918afd6e74829097d3bf452e
https://pubmed.ncbi.nlm.nih.gov/28736855

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