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Akademický článek

Traumatized triad of complementopathy, endotheliopathy, and coagulopathy ˗ Impact on clinical outcomes in severe polytrauma patients

Autor: Zhangsheng Yang, Tuan D. Le, Milomir O. Simovic, Bin Liu, Tamara L. Fraker, Tomas S. Cancio, Andrew P. Cap, Charles E. Wade, Jurandir J. DalleLucca, Yansong Li

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) and mortality. However, the heterogeneity in the responses of complementop

Externí odkaz: https://doaj.org/article/b6ce6c63274a47cb9a1f7940ee04ff76

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Immunopathology of terminal complement activation and complement C5 blockade creating a pro‐survival and organ‐protective phenotype in trauma

Autor: Zhangsheng, Yang, Miles A, Nunn, Tuan D, Le, Milomir O, Simovic, Peter R, Edsall, Bin, Liu, Johnny L, Barr, Brian J, Lund, Crystal D, Hill-Pryor, Anthony E, Pusateri, Leopoldo C, Cancio, Yansong, Li

Publikováno v: British Journal of Pharmacology. 180:422-440

Traumatic haemorrhage (TH) is the leading cause of potentially preventable deaths that occur during the prehospital phase of care. No effective pharmacological therapeutics are available for critical TH patients yet. Here, we identify terminal comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6269f573ee3b046fabf77bc47f7c7d19
https://doi.org/10.1111/bph.15970

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Trends in Traumatic Brain Injury Related to Consumer Products Among U.S. School-aged Children Between 2000 and 2019

Autor: Tuan D. Le, Alan D. Cook, Tony T. Le, John W. Keyloun, Paul W. Detwiler, Gerald R. Ledlow, Anthony E. Pusateri, Karan P. Singh

Publikováno v: American Journal of Preventive Medicine. 63:469-477

Consumer product‒related traumatic brain injury in children is common, but long-term trends have not been well characterized. Understanding the long-term trends in consumer product‒related traumatic brain injury may inform prevention efforts. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f3b858bbe558b983bad2a7dd7ebc02
https://doi.org/10.1016/j.amepre.2022.04.011

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Elderly trauma associated with high-risk recreational activity: A population-based study, United States, 2010 through 2016

Autor: Rebecca Swindall, Jacob W. Roden-Forman, Joseph Conflitti, Alan Cook, Carly Wadle, Julianna Boyle, Jeanette Ward, Brian Gross, Fred Rogers, Tuan D. Le, Scott Norwood

Publikováno v: Surgery. 171:1677-1686

Understanding trends in prevalence and etiology is critical to public health strategies for prevention and management of injury related to high-risk recreation in elderly Americans.The National Emergency Department Sample from 2010 through 2016 was q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3fc88b08d3c845988777af57d620cd
https://doi.org/10.1016/j.surg.2021.11.014

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Assessing Factor V Antigen and Degradation Products in Burn and Trauma Patients

Publikováno v: Journal of Surgical Research. 274:169-177

Proposed mechanisms of acute traumatic coagulopathy (ATC) include decreased clotting potential due to factor consumption and proteolytic inactivation of factor V (FV) and activated factor V (FVa) by activated protein C (aPC). The role of FV/FVa deple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ff2e87e7e5010732ea73826c3ec376
https://doi.org/10.1016/j.jss.2021.12.049

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Analysis of Nonbattle Deaths Among U.S. Service Members in the Deployed Environment

Autor: Karan P. Singh, Heuy-Ching Wang, Tuan D. Le, Anthony E Pusateri, Kevin S. Akers, Kevin K. Chung, Jennifer M. Gurney, Mark E Stackle

Publikováno v: Annals of Surgery. 274:e445-e451

OBJECTIVE Describe etiologies and trends in non-battle deaths (NBD) among deployed U.S. service members to identify areas for prevention. BACKGROUND Injuries in combat are categorized as battle (result of hostile action) or nonbattle related. Previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c344a6a71567c6325e8dc32411975414
https://doi.org/10.1097/sla.0000000000005047

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Traumatized triad of complementopathy, endotheliopathy, and coagulopathy - Impact on clinical outcomes in severe polytrauma patients

Autor: Zhangsheng Yang, Tuan D. Le, Milomir O. Simovic, Bin Liu, Tamara L. Fraker, Tomas S. Cancio, Andrew P. Cap, Charles E. Wade, Jurandir J. DalleLucca, Yansong Li

Publikováno v: Frontiers in immunology. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e314440c95fc22eed4144fe175f3a3
https://pubmed.ncbi.nlm.nih.gov/36341368

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Validating clinical threshold values for a dashboard view of the compensatory reserve measurement for hemorrhage detection

Autor: Mallory Wampler, Kevin K. Chung, John G. Myers, Tuan D. Le, Abdul Q. Alarhayem, Susannah E. Nicholson, Victor A. Convertino, Katie R Struck, Camaren Cuenca, Brian J. Eastridge, Michael Austin Johnson

Publikováno v: Journal of Trauma and Acute Care Surgery. 89:S169-S174

Background Compensatory reserve measurement (CRM) is a novel noninvasive monitoring technology designed to assess physiologic reserve using feature interrogation of arterial pulse waveforms. This study was conducted to validate clinically relevant CR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ade2efc27ff17dabe192faab77aa051
https://doi.org/10.1097/ta.0000000000002586

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