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Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Autor: Zhixia Qiu, Pengfei Xu, Zhiyu Li, Tu Yongrui, Sun Yongqiang, Jinlei Bian, Hai Wang, Peng Peng, Raoling Ge, Jubo Wang, Pei Shen, Chenxi Xu

Publikováno v: Organic Process Research & Development. 24:1477-1483

A scalable and practical route to synthesize the P2Y2 receptor agonist diquafosol tetrasodium has been described. Diquafosol tetrasodium was obtained via a four-step process starting from commercia...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c44f84f3f3ce686d269fa34ed9c85cb7
https://doi.org/10.1021/acs.oprd.0c00209

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Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial

Autor: Lu Qi, Haihong Bai, Ying Liu, Qi Qi, Sun Yongqiang, Rongxia Fan, Zhou Da, Wang Juxiang, Xinghe Wang, Yinjuan Li, Tu Yongrui, Feng Xiaohui

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology

Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations of rasagiline tablets in healthy Chinese subjects under fasting and fed conditions.Methods: An open, randomized, single-dose, double-cycle, two-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354d4b99cf3636757f27f7dbde624958
https://www.frontiersin.org/articles/10.3389/fphar.2020.571747/full

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Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

Autor: Jubo Wang, Xi Xu, Tu Yongrui, Sun Yongqiang, Jinlei Bian, Pengfei Xu, Chen Wei, Bin Yu, Hongyu Luan, Zhiyu Li, Raoling Ge

Publikováno v: Organic Chemistry Frontiers. 6:868-872

Ulipristal acetate (UPA) was developed by Laboratoire HRA Pharma, France and approved by the FDA for emergency contraception in August 2010. Though several methods have been developed for the synthesis of UPA, the steroidal impurities would appear in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed46fce3d8942df6a842de6c685c4a3
https://doi.org/10.1039/c9qo00144a

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Akademický článek

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Akademický článek

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Akademický článek

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Identification and genotoxicity evaluation of two carbamate impurities in rasagiline

Autor: Sun Yongqiang, Xinyu Zhang, Feng Zheng, Yan Yimin, Jiang Wei, Tu Yongrui, Feng Xiaohui

Publikováno v: RSC Advances. 6:106268-106274

During the synthesis of a second-generation monoamine oxidase-B inhibitor rasagiline, two unknown impurities (impurity A and impurity B) were detected and isolated by preparative liquid chromatography. Based on mass spectroscopy and NMR, these two im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f53599c8e23b571ece49dfba3212f9e
https://doi.org/10.1039/c6ra20810j

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Crystal structure of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone

Autor: Mao Qiuxia, Wang Yan, Ge Jilong, Tu Yongrui, Shen Zheng

Publikováno v: Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 70, Iss 10, Pp o1087-o1087 (2014)

In the title molecule, C11H10ClFO2, the benzene ring, the F atom and the O atom of the dihydropyran ring are essentially coplanar, with an r.m.s. deviation of 0.007 Å. The dihydropyran ring is in a half-chair conformation. In the crystal, molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca84f94b98e22e25c5f5ed91af6d6199
http://europepmc.org/articles/PMC4257220

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