Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Tsz-Kwong Man"'
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that
Externí odkaz:
https://doaj.org/article/d4626884e3864b748b5d6fb020d26428
Autor:
Lin Qi, Patricia Baxter, Mari Kogiso, Huiyuan Zhang, Frank K. Braun, Holly Lindsay, Sibo Zhao, Sophie Xiao, Aalaa Sanad Abdallah, Milagros Suarez, Zilu Huang, Wan Yee Teo, Litian Yu, Xiumei Zhao, Zhigang Liu, Yulun Huang, Jack M. Su, Tsz-Kwong Man, Ching C. Lau, Laszlo Perlaky, Yuchen Du, Xiao-Nan Li
Publikováno v:
Cancers, Vol 16, Iss 9, p 1716 (2024)
Background: Despite multimodality therapies, the prognosis of patients with malignant brain tumors remains extremely poor. One of the major obstacles that hinders development of effective therapies is the limited availability of clinically relevant a
Externí odkaz:
https://doaj.org/article/16534c8274c94628b61e903d964703a4
Publikováno v:
Genes and Diseases, Vol 10, Iss 1, Pp 254-266 (2023)
Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be the leading cause of death in patients with osteosarcoma. We have previously reported that
Externí odkaz:
https://doaj.org/article/58bb1d50b8694fce925b28b1a7af00aa
Autor:
Sibo Zhao, Jia Li, Huiyuan Zhang, Lin Qi, Yuchen Du, Mari Kogiso, Frank K. Braun, Sophie Xiao, Yulun Huang, Jianfang Li, Wan-Yee Teo, Holly Lindsay, Patricia Baxter, Jack M. F. Su, Adekunle Adesina, Miklós Laczik, Paola Genevini, Anne-Clemence Veillard, Sol Schvartzman, Geoffrey Berguet, Shi-Rong Ding, Liping Du, Clifford Stephan, Jianhua Yang, Peter J. A. Davies, Xinyan Lu, Murali Chintagumpala, Donald William Parsons, Laszlo Perlaky, Yun-Fei Xia, Tsz-Kwong Man, Yun Huang, Deqiang Sun, Xiao-Nan Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distin
Externí odkaz:
https://doaj.org/article/67ce4ebc1c4e4e89b80aca05d5ec1d5f
Autor:
Jiayi M. Sun, Wing-Yuk Chow, Gufeng Xu, M. John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing Ng, Aaron M. Taylor, Alexander Yu, Jason E. Farrar, Donald A. Barkauskas, Richard Gorlick, Jaime M. Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong Man, Ching C. Lau, on behalf of the TARGET Osteosarcoma Consortium
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12155 (2023)
Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of
Externí odkaz:
https://doaj.org/article/55e97605d05d48298d73d996a1af708f
Autor:
Xiang Chen, Justin M. M. Cates, Yu-Chen Du, Antrix Jain, Sung Yun Jung, Xiao-Nan Li, John M. Hicks, Tsz‐Kwong Man
Publikováno v:
Molecular Oncology, Vol 14, Iss 4, Pp 846-864 (2020)
The development of pulmonary metastasis is the leading cause of death in osteosarcoma (OS), which is the most common malignant bone tumor in children. We have previously reported that the tumor suppressor p27 (KIP1, CDKN1B) is frequently mislocalized
Externí odkaz:
https://doaj.org/article/abe8194521a84310b6dd257de637971c
Autor:
Karen Phaik Har Lim, Paul Milne, Michael Poidinger, Kaibo Duan, Howard Lin, Naomi McGovern, Harshal Abhyankar, Daniel Zinn, Thomas M. Burke, Olive S. Eckstein, Rikhia Chakraborty, Amel Sengal, Brooks Scull, Evan Newell, Miriam Merad, Kenneth L. McClain, Tsz-Kwong Man, Florent Ginhoux, Matthew Collin, Carl E. Allen
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 87-99 (2020)
Abstract: Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder that is characterized by the inflammatory lesions with pathogenic CD1a+CD207+ dendritic cells (DCs). BRAFV600E and other somatic activating MAPK gene mutations have been i
Externí odkaz:
https://doaj.org/article/c86f478e226541b0bac33e2a435850d6
Autor:
Yulun Huang, Lin Qi, Mari Kogiso, Yuchen Du, Frank K. Braun, Huiyuan Zhang, L. Frank Huang, Sophie Xiao, Wan‐Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Jack M. F. Su, Adekunle Adesina, Jianhua Yang, Sebastian Brabetz, Marcel Kool, Stefan M. Pfister, Murali Chintagumpala, Laszlo Perlaky, Zhong Wang, Youxin Zhou, Tsz‐Kwong Man, Xiao‐Nan Li
Publikováno v:
Advanced Science, Vol 8, Iss 23, Pp n/a-n/a (2021)
Abstract Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching pairs of invasive (G
Externí odkaz:
https://doaj.org/article/d951663ff7d440bebd6494e2644f1aa3
Autor:
Aaron M. Taylor, Jiayi M. Sun, Alexander Yu, Horatiu Voicu, Jianhe Shen, Donald A. Barkauskas, Timothy J. Triche, Julie M. Gastier-Foster, Tsz-Kwong Man, Ching C. Lau
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 8036 (2022)
Osteosarcoma is a primary malignant bone tumor arising from bone-forming mesenchymal cells in children and adolescents. Despite efforts to understand the biology of the disease and identify novel therapeutics, the survival of osteosarcoma patients re
Externí odkaz:
https://doaj.org/article/8010e2de4ec4484c8d2c0da1398bdd93
Autor:
Jennifer E. Agrusa, Brooks P. Scull, Harshal A. Abhyankar, Howard Lin, Nmazuo W. Ozuah, Rikhia Chakraborty, Olive S. Eckstein, Nitya Gulati, Elmoataz Abdel Fattah, Nader K. El-Mallawany, Rayne H. Rouce, ZoAnn E. Dreyer, Julienne Brackett, Judith F. Margolin, Joseph Lubega, Terzah M. Horton, Catherine M. Bollard, M. Monica Gramatges, Kala Y. Kamdar, Kenneth L. McClain, Tsz-Kwong Man, Carl E. Allen
Publikováno v:
Cancers, Vol 12, Iss 12, p 3603 (2020)
Hodgkin lymphoma (HL) histopathology is characterized by rare malignant Reed–Sternberg cells among an inflammatory infiltrate. We hypothesized that characteristics of inflammation in pediatric HL lesions would be reflected by the levels of inflamma
Externí odkaz:
https://doaj.org/article/ba0b5b58235844d49d2770cc133d9092