Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tsz Ying Yuen"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Anthony W. Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Pradhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherborne, David P. Lane, Tomi K. Sawyer
Publikováno v:
Molecules, Vol 24, Iss 12, p 2292 (2019)
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space
Externí odkaz:
https://doaj.org/article/76dd0b05d6584b64a066db0da685651e
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro Aronica, Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Brian Henry, Marika Nestor, Chandra S Verma, David Lane, Tomi Sawyer, Robert Garbaccio, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W Johannes, Anthony William Partridge
Stapled α-helical peptides can bind to and modulate historically intractable targets while addressing the traditional liabilities associated with peptide therapeutics. However, their pipeline advancement has been impeded by the challenges of identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f15998d22633b086d54b5c6b03932d
https://doi.org/10.1101/2023.02.25.530030
https://doi.org/10.1101/2023.02.25.530030
Autor:
Kristal Kaan, Nicole Boo, Yu-Chi Angela Juang, Chandra S. Verma, Kaustav Biswas, Ruchia Duggal, Christopher J. Brown, Bhvana Bhatt, Chunhui Huang, Simon Ng, Ahmad Sadruddin, Nianyu Jason Li, Srinivasaraghavan Kannan, Shuhui Lim, Xiang Yu, Charles W. Johannes, Andrea M. Peier, Anthony W. Partridge, Erjia Wang, Lan Ge, Michael Garrigou, Pooja Gopal, Gireedhar Venkatachalam, Brian Henry, Nicolas Boyer, Khong Ming Peh, Tsz Ying Yuen, Raymond J. Gonzalez, Feifei Chen, Tomi K. Sawyer, Alexander Stoeck, Peter Orth, David P. Lane
Publikováno v:
Chemical Science
Macrocyclic peptides have the potential to address intracellular protein–protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying
Autor:
Charles W. Johannes, Dawn Thean, Joe R Cannon, Raymond Evers, Tanvi Desai, Hung Yi Kristal Kaan, David P. Lane, Christopher J. Brown, Ahmad Sadruddin, Anthony W. Partridge, Tsz Ying Yuen, Arun Chandramohan, Tomi K. Sawyer, Jerome Hochman, Bahanu Habulihaz
Publikováno v:
Pharmaceutical Research. 38:843-850
To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo cyclooctyne biotin (DBCO-Biotin) to conjugate azido modified peptides that may effectively transloca
Autor:
Julian L. Goggi, You Yi Hwang, Siddesh V. Hartimath, Beverly Jieu, Shivashankar Khanapur, Tsz Ying Yuen, Tan Yun Xuan, Laurent Rénia, Ann-Marie Chacko, Rasha Msallam, Yong Fui Fong, Peter Cheng, Boominathan Ramasamy, Tang Jun Rong, Edward G. Robins, Hui Xian Chin, Charles W. Johannes
Publikováno v:
Molecular Imaging and Biology
Purpose Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU), that enhance the immune system, are being assessed as strategies to improve durable response rates when used in combination with immune checkpoint inhibitor (ICI
Autor:
Tsz Ying Yuen, Lingfan Jiang, Y. Y. Hwang, H. X. Chin, Beverly Jieu, Yingrou Tan, J. R. Tang, Julian L. Goggi, Charles W. Johannes, Siddesh V. Hartimath, Peter Cheng, Edward G. Robins, Laurent Rénia, Anis Larbi, Ann-Marie Chacko, R. Boominathan
Publikováno v:
Molecular Imaging and Biology
Purpose Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understoo
Autor:
Julian L. Goggi, Peng Wen Tan, Beverly Jieu, Anis Larbi, Peter Cheng, Boominathan Ramasamy, Lingfan Jiang, Youyi Hwang, Siddesh V. Hartimath, Fui Fong Yong, Shivashankar Khanapur, Charles W. Johannes, Yun Xuan Tan, Laurent Rénia, Mohamed Ar Husaini, Ann-Marie Chacko, Edward G. Robins, Tsz Ying Yuen
Publikováno v:
Molecular Imaging and Biology. 22:993-1002
Cancer immunotherapy has shown huge potential in the fight against cancer, but only a small proportion of patients respond successfully to treatment. Non-invasive methods to stratify responders from non-responders are critically important as immune t
Autor:
Hung Yi Kristal Kaan, Yi Han, Charles W. Johannes, Laurent Rénia, Zi Wei Chang, Brian Henry, Yaw Sing Tan, Arun Chandramohan, Yuri Frosi, Tomi K. Sawyer, Chandra S. Verma, Shiying Chen, Dawn Thean Gek Lian, Simon Ng, Tsz Ying Yuen, Jiang Shimin, Ahmad Sadruddin, Jin Huei Wong, Pietro G. A. Aronica, Christopher J. Brown, David P. Lane, Srinivasaraghavan Kannan, Prakash Arumugam, Anthony W. Partridge, Sharon Chee, Fernando J. Ferrer-Gago
Publikováno v:
Chemical Science. 11:5577-5591
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these m
Publikováno v:
The Journal of Organic Chemistry. 85:1556-1566
α,α'-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α'-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids wer