Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tsz Yat Luk"'
Autor:
Yufei Mo, Ming Yue, Lok Yan Yim, Runhong Zhou, Chunhao Yu, Qiaoli Peng, Ying Zhou, Tsz-Yat Luk, Grace Chung-Yan Lui, Huarong Huang, Chun Yu Hubert Lim, Hui Wang, Li Liu, Hongzhe Sun, Jun Wang, Youqiang Song, Zhiwei Chen
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104877- (2023)
Summary: Background: HIV-1-associated immune activation drives CD4+ T cell depletion and the development of acquired immunodeficiency syndrome. We aimed to determine the role of nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide
Externí odkaz:
https://doaj.org/article/54e9a91cd4604b2a9a8e451b41efab99
Autor:
Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Looking for metabolic-associated vulnerabilities is a promising approach for therapeutic intervention in KRAS-mutant colorectal cancer. Here, the authors show that the cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic targ
Externí odkaz:
https://doaj.org/article/b983ec1445e54ade901f9b1e5f30d6ee
Autor:
Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in rapid T lymphocytopenia and functional impairment of T cells. The underlying mechanism, however, remains incompletely understood. In this study, we focused on character
Externí odkaz:
https://doaj.org/article/847b178133554300bd35131d3ec55877
Autor:
Lok Yan Yim, Ka Shing Lam, Tsz-Yat Luk, Yufei Mo, Xiaofan Lu, Jinlin Wang, Ka-Wai Cheung, Grace Chung Yan Lui, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Thomas Tsz-Kan Lau, Chiu Bong Ngan, Dongyan Zhou, Yik Chun Wong, Zhiwu Tan, Li Liu, Hao Wu, Tong Zhang, Shui Shan Lee, Zhiwei Chen
Publikováno v:
Journal of Virology. 97
Incomplete eradication of HIV-1 latency reservoirs remains the major hurdle in achieving a complete HIV/AIDS cure. Dissecting the facilitator of latency reservoir establishment may aid the discovery of druggable targets for HIV-1 cure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7417e4f0b2aab3a478db5361cb5db60
https://doi.org/10.1128/jvi.00270-23
https://doi.org/10.1128/jvi.00270-23
Autor:
Yun Qian, Lianxin Zhou, Simson Tsz Yat Luk, Jiaying Xu, Weilin Li, Hongyan Gou, Huarong Chen, Wei Kang, Jun Yu, Chi Chun Wong
Publikováno v:
Oncogene.
The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions as a tumor suppressor. SCNN1B mRNA and protein expression were down-regulated in primary CRC and CRC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bca852492d23115b10d1f7bc45e239
https://pubmed.ncbi.nlm.nih.gov/36564468
https://pubmed.ncbi.nlm.nih.gov/36564468
Autor:
Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu
Publikováno v:
Nature communications. 13(1)
Therapeutic targeting of KRAS-mutant colorectal cancer (CRC) is an unmet need. Here, we show that Proprotein Convertase Subtilisin/Kexin type 9 (PSCK9) promotes APC/KRAS-mutant CRC and is a therapeutic target. Using CRC patient cohorts, isogenic cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7d088ca604612546c3e6348305f2dc
https://pubmed.ncbi.nlm.nih.gov/35803966
https://pubmed.ncbi.nlm.nih.gov/35803966
Autor:
Zhiwei Chen, Wai Shing Leung, Tsz Yat Luk, Pauline Yeung, Kelvin K. W. To, Runhong Zhou, Thomas Tsz Kan Lau, Yik Chun Wong, Wai-Ming Chan, Xin Li, Li Liu, Alan Ka Lun Wu, Haode Huang, Owen Tak-Yin Tsang, Biao Zhou, Ivan Hung, Kwok-Yung Yuen, Kwok Cheung Lung, Yufei Mo
Publikováno v:
Immunity
Summary The SARS-CoV-2 pandemic has resulted in millions of infections yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By investigating 17 acute and 24 convalescent patients, we found that acute SARS-CoV-2 infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cab7dff579e08e385cd13028e2f555
Autor:
Xiaoming Zhang, Jiaying Xu, Yun Qian, Enders Kw Ng, Huarong Chen, Liuyang Zhao, Jun Yu, Phlip Wy Chiu, Chi Chun Wong, Weilin Li, Simson Tsz Yat Luk, Wei Kang
Publikováno v:
Theranostics. 9:6256-6268
Rationale: Prostaglandin E2 (PGE2) is a pro-inflammatory eicosanoid up-regulated in gastric cancer (GC). However, its impact on epigenetic dysfunction in the process of gastric carcinogenesis is unknown. In this study, we investigate the role of PGE2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51b58e81a278d94d7320eca3b705a24c
https://doi.org/10.7150/thno.35766
https://doi.org/10.7150/thno.35766
Autor:
Lam-Shing Chan, Chi Chun Wong, Wei Kang, Senji Shirasawa, Fenfen Ji, Huarong Chen, Simson Tsz Yat Luk, Jian-Lin Wu, Dabin Liu, Xiqing Bian, Jiaying Xu, Weilin Li, Yun Qian, Joseph J.Y. Sung, Qiming Zhou, Jun Yu, Hongyan Gou
Publikováno v:
Gastroenterology. 159(6)
Background & Aims Mutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules via glutaminase and SLC25A22. This results in inhibition of demethylases and ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0235602ba0f5bb2c9f15d99687f61fd5
https://pubmed.ncbi.nlm.nih.gov/32814111
https://pubmed.ncbi.nlm.nih.gov/32814111
Autor:
Biao Zhou, Xin Li, Zhiwei Chen, Runhong Zhou, Kelvin K. W. To, Thomas Tsz Kan Lau, Ivan Hung, Li Liu, Pauline Yeung, Kwok-Yung Yuen, Yik Chun Wong, Owen Tak-Yin Tsang, Tsz Yat Luk, Kwok Cheung Lung, Yufei Mo, Wai-Ming Chan, Alan Ka Lun Wu, Wai Shing Leung, Haode Huang
Publikováno v:
SSRN Electronic Journal.
SARS-CoV-2 pandemic has resulted in over 4 million infections yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By evaluating 15 acute and 24 convalescent patients’ immune profile, we report herein acute SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00101150aa551ae24dc6899522865b4f
https://doi.org/10.2139/ssrn.3614132
https://doi.org/10.2139/ssrn.3614132