Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy

Autor: Jin Hui Hor, Shuwen Chen, Gamal Ahmed Elfar, Chit Fang Cheok, Nicholas Phua, Tsz Wai Ngai, Ying Swan Ho, Pearlyn Yeo

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10420, p 10420 (2021)

Niclosamide is an oral anthelmintic drug, approved for use against tapeworm infections. Recent studies suggest however that niclosamide may have broader clinical applications in cancers, spurring increased interest in the functions and mechanisms of

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