Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tsz M Tsang"'
Autor:
Sandrine P Claus, Tsz M Tsang, Yulan Wang, Olivier Cloarec, Eleni Skordi, François‐Pierre Martin, Serge Rezzi, Alastair Ross, Sunil Kochhar, Elaine Holmes, Jeremy K Nicholson
Publikováno v:
Molecular Systems Biology, Vol 4, Iss 1, Pp 1-14 (2008)
Abstract To characterize the impact of gut microbiota on host metabolism, we investigated the multicompartmental metabolic profiles of a conventional mouse strain (C3H/HeJ) (n=5) and its germ‐free (GF) equivalent (n=5). We confirm that the microbio
Externí odkaz:
https://doaj.org/article/014e87089ee643779a114e7f7f4c4d53
Autor:
Jeffrey T-J Huang, F Markus Leweke, Tsz M Tsang, Dagmar Koethe, Laura Kranaster, Christoph W Gerth, Sonja Gross, Daniela Schreiber, Stephan Ruhrmann, Frauke Schultze-Lutter, Joachim Klosterkötter, Elaine Holmes, Sabine Bahn
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e756 (2007)
BACKGROUND: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical ch
Externí odkaz:
https://doaj.org/article/f6a9aae8d688456fb433348f6c376a7d
Autor:
Elaine Holmes, Tsz M Tsang, Jeffrey T-J Huang, F Markus Leweke, Dagmar Koethe, Christoph W Gerth, Brit M Nolden, Sonja Gross, Daniela Schreiber, Jeremy K Nicholson, Sabine Bahn
Publikováno v:
PLoS Medicine, Vol 3, Iss 8, p e327 (2006)
BackgroundThe identification of schizophrenia biomarkers is a crucial step towards improving current diagnosis, developing new presymptomatic treatments, identifying high-risk individuals and disease subgroups, and assessing the efficacy of preventat
Externí odkaz:
https://doaj.org/article/a0ddbe33456c4f0c99bb5b3d5c51c7be
Autor:
Ivo Gut, Nicolas Venteclef, Georg W. Otto, Fawaz Alzaid, Tsz M. Tsang, Christopher P. Day, Mark Lathrop, Marc-Emmanuel Dumas, Jeremy K. Nicholson, Aurélie Le Lay, Jean-Baptiste Cazier, Lyamine Hedjazi, Jane F. Fearnside, Francois Brial, Dominique Gauguier, Alastair D. Burt, Steven P. Wilder
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3656. ⟨10.1038/s41598-019-40153-0⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3656. ⟨10.1038/s41598-019-40153-0⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Non-alcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. To disentangle etiological relationships between these conditions and identify genetically-determined metabolites involved in NAFLD processes, we mapped 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae1a745d29524ba1e96ca10fbaa0f6b
Autor:
Emanuel Schwarz, Sabine Bahn, Agnes Ernst, Zoltán Sarnyai, Wolfgang Kluge, Dan Ma, Paul C. Guest, Isabel Garcia-Perez, Tsz M. Tsang, Elaine Holmes
Publikováno v:
Journal of Proteome Research, 11(7), 3704-3714. American Chemical Society
Administration of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) to rodents is widely used as preclinical model for schizophrenia. Most studies on this model employ methods investigating behavior and brain abno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5d39c179d6cb555edeaf9f5963ecbb
https://doi.org/10.1021/pr300197d
https://doi.org/10.1021/pr300197d
Autor:
Karène Argoud, Yulan Wang, Dominique Gauguier, Steve Chappell Mitchell, Benjamin J. Blaise, Timothy M. D. Ebbels, John C. Lindon, Pamela J. Kaisaki, Jean-Baptiste Cazier, Kirill Veselkov, Jeremy K. Nicholson, Elaine Holmes, Tsz M. Tsang, James Scott, Marie-Thérèse Bihoreau, Marc-Emmanuel Dumas
Publikováno v:
Journal of Proteome Research
Journal of Proteome Research, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research, American Chemical Society, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research; Vol 11
Journal of Proteome Research, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research, American Chemical Society, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research; Vol 11
With successes of genome-wide association studies, molecular phenotyping systems are developed to identify genetically determined disease-associated biomarkers. Genetic studies of the human metabolome are emerging but exclusively apply targeted appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe41f4eb73a1fdc4eb6cb5af764e5da1
Autor:
Graham L. Collingridge, Viktor Lakics, Tammy M. K. Cheng, Stephen M. Fitzjohn, John L. Sherwood, Nadia Malik, Sabine Bahn, Hassan Rahmoune, Thomas M. Sanderson, Mark D. Tricklebank, Elaine Holmes, Emanuele Sher, Tsz M. Tsang, Michael J. O'Neill, Stephanie Schoeffmann, Eva Hradetzky, Laura W. Harris, Paul C. Guest
Publikováno v:
Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, 2011, ⟨10.1038/npp.2011.219⟩
Neuropsychopharmacology, 37(2), 364-377. Nature Publishing Group
Neuropsychopharmacology, Nature Publishing Group, 2011, ⟨10.1038/npp.2011.219⟩
Neuropsychopharmacology, 37(2), 364-377. Nature Publishing Group
Administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on embryonic day 17 (E17) produces behavioral and anatomical brain abnormalities, which model some aspects of schizophrenia. This has lead to the premise that MAM rats are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac99e5aeede91a0360eed93dcf664a55
https://doi.org/10.1038/npp.2011.219
https://doi.org/10.1038/npp.2011.219
Autor:
Sabine Bahn, Dan Ma, Tsz M. Tsang, Isabel M Benzel, Declan N C Jones, Gerard A McLoughlin, Elaine Holmes, Jackie Cilia, Melanie J Robbins, Mark D Hill, Peter R Maycox
Publikováno v:
Journal of Proteome Research. 8:1943-1952
The mechanism of action of standard drug treatments for psychiatric disorders remains fundamentally unknown, despite intensive investigation in academia and the pharmaceutical industry. So far, little is known about the effects of psychotropic medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc807541c523c7339360d4ebb80e68b6
https://doi.org/10.1021/pr800892u
https://doi.org/10.1021/pr800892u
Autor:
Peixiong Yuan, M J Lan, Julian L. Griffin, Sabine Bahn, Elaine Holmes, Gerard A McLoughlin, Husseini K. Manji, Tsz M. Tsang, Jeffrey T.-J. Huang
Publikováno v:
Molecular Psychiatry. 14:269-279
Bipolar affective disorder is a severe and debilitating psychiatric condition characterized by the alternating mood states of mania and depression. Both the molecular pathophysiology of the disorder and the mechanism of action of the mainstays of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93f3c9c302e8356171ccdbbcae640f
https://doi.org/10.1038/sj.mp.4002130
https://doi.org/10.1038/sj.mp.4002130
Publikováno v:
Journal of Proteome Research. 5:756-760
(1)H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7068137501a9009e99c7fdb3ef16bca4
https://doi.org/10.1021/pr0503782
https://doi.org/10.1021/pr0503782