Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity

Autor: Samu, D, Campbell, KL, Tsvetanov, KA, Shafto, MA, Cam-CAN, Tyler, LK

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45755c0dffd6b19b87d00ce71df46432

Neuroinflammation and functional connectivity in Alzheimer’s disease: interactive influences on cognitive performance

Autor: P.S. Jones, James B. Rowe, William Richard Bevan-Jones, Kamen A. Tsvetanov, John T. O'Brien, Elijah Mak, Li Su, Robin J Borchert, Robert Arnold, Luca Passamonti

Publikováno v: The journal of neuroscience (Online) 39 (2019): 7218–7226. doi:10.1523/JNEUROSCI.2574-18.2019
info:cnr-pdr/source/autori:Passamonti L.; Tsvetanov K.A.; Jones P.S.; Bevan-Jones W.R.; Arnold R.; Borchert R.J.; Mak E.; Su L.; O'Brien J.T.; Rowe J.B./titolo:Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance/doi:10.1523%2FJNEUROSCI.2574-18.2019/rivista:The journal of neuroscience (Online)/anno:2019/pagina_da:7218/pagina_a:7226/intervallo_pagine:7218–7226/volume:39
The Journal of Neuroscience

Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer’s disease. We test the relationship between neuroinflammation and the disruption of functional connectivity in large-scale networks, and their joint influence on cognitive impair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a2a75ff68d3e63ab67502efd2c9811

Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion.

Autor: Liu X; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK., Jones PS; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK., Pasternak M; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Canada.; University of Toronto, Toronto, Canada., Masellis M; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Canada.; University of Toronto, Toronto, Canada., Bouzigues A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK., Russell LL; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK., Foster PH; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK., Ferry-Bolder E; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK., van Swieten J; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Jiskoot L; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Seelaar H; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Sanchez-Valle R; Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain., Laforce R; Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Québec, Canada., Graff C; Karolinska Institute, Department NVS, Centre for Alzheimer Research, Division of Neurogenetics, Stockholm, Sweden.; Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Stockholm, Sweden., Galimberti D; Fondazione IRCCS Ospedale Policlinico, Milan, Italy.; Centro Dino Ferrari, University of Milan, Milan, Italy., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospitals Leuven, Leuven, Belgium., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Tiraboschi P; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy., Santana I; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Centre of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal., Gerhard A; Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, First floor, Core Technology Facility, Manchester, UK.; Department of Nuclear Medicine, Centre for Translational Neuro- and Behavioral Sciences, University Medicine Essen, Essen, Germany.; Department of Geriatric Medicine, Klinikum Hochsauerland, Arnsberg, Germany., Levin J; Department of Neurology, Ludwig-Maximilians Universität München, Munich, Germany.; Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology, Munich, Germany., Sorbi S; Department of Neurofarba, University of Florence, Firenze, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Firenze, Italy., Otto M; Department of Neurology, University of Ulm, Ulm, Germany., Pasquier F; University Lille, Lille, France.; Inserm 1172, Lille, France.; CHU, CNR-MAJ, Labex Distalz, LiCEND Lille, Lille, France., Ducharme S; Department of Psychiatry, McGill University Health Centre, McGill University, Montreal, Canada.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada., Butler C; Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.; Department of Brain Sciences, Imperial College London, Burlington Danes, The Hammersmith Hospital, London, UK., Le Ber I; Paris Brain Institute - Institut du Cerveau - ICM, Sorbonne Université, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France.; Reference center for rare or early-onset dementias, IM2A, Department of Neurology, AP-HP - Pitié-Salpêtrière Hospital, Paris, France.; Department of Neurology, AP-HP - Pitié-Salpêtrière Hospital, Paris, France., Finger E; Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Disease, Toronto Western Hospital, Toronto, Ontario, Canada., Synofzik M; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research & Centre of Neurology, University of Tübingen, Tübingen, Germany.; Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Moreno F; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain.; Neuroscience Area, Biodonostia Health Research Institute, San Sebastian, Gipuzkoa, Spain., Borroni B; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Rohrer JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK., Tsvetanov KA; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK., Rowe JB; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.; MRC Cognition and Brain Science Unit, University of Cambridge, Cambridge, UK.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration.

Autor: Malpetti M; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Swann P; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QQ, UK., Tsvetanov KA; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK.; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK., Chouliaras L; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QQ, UK., Strauss A; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Chikaura T; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Murley AG; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Ashton NJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, S-431 80, Sweden.; Wallenberg Centre for Molecular Medicine, University of Gothenburg, Gothenburg, S-413 45, Sweden.; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, SE5 9RT, UK.; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, SE5 8AF, UK., Barker P; NIHR Cambridge Biomedical Research Centre, Core BiochemicalAssay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Jones PS; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Fryer TD; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Hong YT; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Cope TE; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK.; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK., Savulich G; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QQ, UK., Street D; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Bevan-Jones WR; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QQ, UK., Rittman T; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, S-431 80, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, S-431 80, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, S-431 80, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, S-431 80, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 6BG, UK.; UK Dementia Research Institute at UCL, London, WC1N 6BG, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53792, USA., Aigbirhio FI; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK., O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0QQ, UK., Rowe JB; University of Cambridge Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, Cambridge, CB2 0SZ, UK.; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Aug 19. Date of Electronic Publication: 2024 Aug 19.

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

Autor: Whiteside DJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. djw216@cam.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. djw216@cam.ac.uk., Holland N; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Tsvetanov KA; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Mak E; Department of Psychiatry, University of Cambridge, Cambridge, UK., Malpetti M; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Savulich G; Department of Psychiatry, University of Cambridge, Cambridge, UK., Jones PS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Naessens M; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Rouse MA; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Fryer TD; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK., Hong YT; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK., Aigbirhio FI; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK., Mulroy E; UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Bhatia KP; UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Rittman T; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., O'Brien JT; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK., Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 20; Vol. 14 (1), pp. 8458. Date of Electronic Publication: 2023 Dec 20.