Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tsuzuki, Hiroshige"'
Publikováno v:
European Journal of Biochemistry. 9/1/94, Vol. 224 Issue 2, p735-742. 8p.
Autor:
Kitadokoro, Kengo1, Tsuzuki, Hiroshige1, Nakamura, Etsuo1, Sato, Tomohiro1, Teraoka, Hiroshi1
Publikováno v:
European Journal of Biochemistry. 2/15/94, Vol. 220 Issue 1, p55-61. 7p. 3 Diagrams, 5 Charts, 1 Graph.
Autor:
Morihara, Kazuyuki1, Tsuzuki, Hiroshige1
Publikováno v:
European Journal of Biochemistry. 1970, Vol. 15 Issue 2, p374-380. 7p.
Autor:
Naohiro Itoh, Yutaka Hashimoto, Hitoshi Nakazato, Yoshikazu Kambayashi, Tsuzuki Hiroshige, Takayuki Kuroda, Kenji Asakura, Gaku Sakaguchi, Toshiyuki Sakaeda, Satoshi Hata, Tatsurou Yagami, Keiichi Ueda
Publikováno v:
Brain Research. 959:328-335
Cerebrospinal fluid prostaglandin E(2) (PGE(2)) levels are elevated in patients with Alzheimer's disease (AD), suggesting an involvement of PGE(2) in the neurodegeneration. AD is characterized by deposits of amyloid beta protein (Abeta) in various re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964918c5b943088ad0c5257744b707f8
https://doi.org/10.1016/s0006-8993(02)03773-3
https://doi.org/10.1016/s0006-8993(02)03773-3
Autor:
Hiroyuki Okamoto, Yayoi Matsumoto, Tsuzuki Hiroshige, Hideo Maki, Hiroshi Yoshida, Kazuyo Nishida-Nishimoto, Ryuji Maekawa, Takayuki Yoshioka, Tohru Wada
Publikováno v:
Clinical & Experimental Metastasis. 18:61-66
The anti-metastatic efficacy and safety of a newly-developed matrix metalloproteinase (MMP) inhibitor were examined. MMI-166, a N-sulfonylamino acid derivative, inhibited the enzyme activity of MMP-2, 9, and 14 but not MMP-1, 3 or 7. Daily oral admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d951886361ab7445e8317c0022576e7a
https://doi.org/10.1023/a:1026553414492
https://doi.org/10.1023/a:1026553414492
Autor:
Yoshinori Tamura, Mitsuaki Yodo, Tsuzuki Hiroshige, Fumihiko Watanabe, Mitsuaki Ohtani, Ryuichi Kiyama
Publikováno v:
Journal of Medicinal Chemistry. 42:1723-1738
Three-dimensional models for the catalytic domain of gelatinases (MMP-9 and -2) have been constructed based on the X-ray crystal structure of MMP-3. Conformations of the loop segment which forms the bottom half of the S1' subsite but shows conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdde0dab09c28a5966a89000090fae4
https://doi.org/10.1021/jm980514x
https://doi.org/10.1021/jm980514x
Autor:
Ryuji Maekawa, Yoshinori Tamura, Kenji Sugita, Ken Yasui, Takuji Nakatani, Kenji Kawada, Yoshioka Takayuki, Mitsuaki Ohtani, Masahiro Fuji, Fumihiko Watanabe, Tadafumi Komurasaki, Tsuzuki Hiroshige
Publikováno v:
Journal of medicinal chemistry. 41(4)
Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be58a05a400ef4ea0b774d3f247114c
https://pubmed.ncbi.nlm.nih.gov/9484512
https://pubmed.ncbi.nlm.nih.gov/9484512
Autor:
Maekawa, Ryuji, Maki, Hideo, Wada, Tohru, Yoshida, Hiroshi, Nishida-Nishimoto, Kazuyo, Okamoto, Hiroyuki, Matsumoto, Yayoi, Tsuzuki, Hiroshige, Yoshioka, Takayuki
Publikováno v:
Clinical & Experimental Metastasis; Jan2000, Vol. 18 Issue 1, p61-66, 6p
Autor:
Ishizaki, Jun, Tamaki, Mikio, Shin, Masaru, Tsuzuki, Hiroshige, Yoshikawa, Kazumasa, Teraoka, Hiroshi, Yoshida, Nobuo
Publikováno v:
Applied Microbiology & Biotechnology; 1992, Vol. 36 Issue 4, p483-486, 4p
Publikováno v:
Journal of Biochemistry; Mar1984, Vol. 95 Issue 3, p795-804, 10p