Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tsuyoshi Yanagimachi"'
Autor:
Seiichiro Ohgaku, Shogo Ida, Natsuko Ohashi, Katsutaro Morino, Atsushi Ishikado, Tsuyoshi Yanagimachi, Koichiro Murata, Daisuke Sato, Satoshi Ugi, Ali Nasiri, Gerald I. Shulman, Hiroshi Maegawa, Shinji Kume, Yukihiro Fujita
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34490- (2024)
Introduction: Endothelial cells have a crucial function in transporting and exchanging various nutrients. O-GlcNAcylation, mediated by O-GlcNAc transferase (OGT), involves the addition of N-acetylglucosamine to proteins and serves as an intracellular
Externí odkaz:
https://doaj.org/article/190378ccdc7a445c9e011d3f60bd64c6
Autor:
Saki Kobayashi, Katsutaro Morino, Takuya Okamoto, Mitsumi Tanaka, Shogo Ida, Natsuko Ohashi, Koichiro Murata, Tsuyoshi Yanagimachi, Juro Sakai, Hiroshi Maegawa, Yukihiro Fujita, Shinji Kume
Publikováno v:
Physiological Reports, Vol 12, Iss 11, Pp n/a-n/a (2024)
Abstract Acetate is a short‐chain fatty acid (SCFA) that is produced by microbiota in the intestinal tract. It is an important nutrient for the intestinal epithelium, but also has a high plasma concentration and is used in the various tissues. Acet
Externí odkaz:
https://doaj.org/article/a85038574ae243b2ba945b798e941436
Autor:
Kimihiro Nishimura, Yukihiro Fujita, Shogo Ida, Tsuyoshi Yanagimachi, Natsuko Ohashi, Kiyoto Nishi, Atsushi Nishida, Yasumasa Iwasaki, Katsutaro Morino, Satoshi Ugi, Eiichiro Nishi, Akira Andoh, Hiroshi Maegawa
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101458- (2022)
Objective: The intestine is an important organ for nutrient metabolism via absorption and endocrine systems. Nutrients regulate O-GlcNAcylation, a post-translational modification of various proteins by O-GlcNAc transferase (OGT). We have previously s
Externí odkaz:
https://doaj.org/article/88a84a67372841a5b9e666455a45dd79
Autor:
Yasutaka Takeda, Yukihiro Fujita, Ryoichi Bessho, Mao Sato, Tomoe Abe, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota, Masakazu Haneda
Publikováno v:
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon duri
Externí odkaz:
https://doaj.org/article/aab131bd969343559afca99589933d8b
Autor:
Yukihiro Fujita, Kuralay K. Atageldiyeva, Yasutaka Takeda, Tsuyoshi Yanagimachi, Yuichi Makino, Masakazu Haneda
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
ObjectiveA low-carbohydrate diet (LC) can be beneficial to obese subjects with type2 diabetes mellitus (T2DM). Sodium-glucose cotransporter 2 inhibitor (SGLT2i) presents prompt glucose-lowering effects in subjects with T2DM. We investigated how LC an
Externí odkaz:
https://doaj.org/article/0390a136b35f49c588701e6adf104893
Autor:
Yasutaka Takeda, Yukihiro Fujita, Tsuyoshi Yanagimachi, Nobuhiro Maruyama, Ryoichi Bessho, Hidemitsu Sakagami, Jun Honjo, Hiroki Yokoyama, Masakazu Haneda
Publikováno v:
Physiological Reports, Vol 8, Iss 11, Pp n/a-n/a (2020)
Abstract The short‐form glucose‐dependent insulinotropic polypeptide (GIP) (1–30) is released from islet alpha cells and promotes insulin secretion in a paracrine manner in vitro. However, it is not well elucidated how GIP (1–30) is involved
Externí odkaz:
https://doaj.org/article/b7f797beea1445df873c63d45e036208
Autor:
Tsuyoshi Yanagimachi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Hiroki Yokoyama, Masakazu Haneda
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Objective: We recently observed a greater increase in plasma levels of bioactive glucose-dependent insulinotropic polypeptide (GIP) than glucagon-like peptide 1 (GLP-1) using the receptor-mediated bioassays in the subjects with normal glycemic tolera
Externí odkaz:
https://doaj.org/article/452dad60c5ee4f089114da82a6eb7ee9
Autor:
Yumi Takiyama, Toshihiro Sera, Masanori Nakamura, Kanaki Ishizeki, Yasuaki Saijo, Tsuyoshi Yanagimachi, Manami Maeda, Ryoichi Bessho, Takao Takiyama, Hiroya Kitsunai, Hidemitsu Sakagami, Daisuke Fujishiro, Yukihiro Fujita, Yuichi Makino, Atsuko Abiko, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Tsuguhito Ota, Masakazu Haneda
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 329-346 (2018)
Background: Recent large-scale clinical studies demonstrate that sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the diabetic kidney. However, clinical and animal studies have not shown the changes of the total glomeruli in the whole kidney
Externí odkaz:
https://doaj.org/article/e0c854294846408e9992931b31f45d40
Autor:
Yasutaka Takeda, Yukihiro Fujita, Kentaro Sakai, Tomoe Abe, Tomonobu Nakamura, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Jun Honjo, Atsuko Abiko, Yuichi Makino, Masakazu Haneda
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-6 (2017)
MEN1-associated pancreatic neuroendocrine tumors (pNETs) may potentially express distinct hormones, but the mechanism has not been elucidated. Transcription factors such as MafA and Pdx1 have been identified to lead to beta cell differentiation, whil
Externí odkaz:
https://doaj.org/article/e78f6851309f4bbabb7579ce9024c9b8
Autor:
Tsuyoshi Yanagimachi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Hidemitsu Sakagami, Hiroya Kitsunai, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Timothy J. Kieffer, Masakazu Haneda
Publikováno v:
Molecular Metabolism, Vol 6, Iss 2, Pp 226-231 (2017)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have be
Externí odkaz:
https://doaj.org/article/4cfa0b178d4546af941392b8be0dd0fc