Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Tsuyoshi Waku"'
Autor:
Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis. When the proteasome is dysfunctional, cells compensate for impaired
Externí odkaz:
https://doaj.org/article/bc0f3920b3e946c5a9636b0de053c70e
Autor:
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, Atsushi Hatanaka, Tsuyoshi Osawa, Tomoyoshi Soga, Akira Kobayashi
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106045- (2023)
Summary: Cancer cells coordinate the mTORC1 signals and the related metabolic pathways to robustly and rapidly grow in response to nutrient conditions. Although a CNC-family transcription factor NRF3 promotes cancer development, the biological releva
Externí odkaz:
https://doaj.org/article/94a3d01baf604a83a67455cb7ad7597c
Autor:
Tsuyoshi Waku, Sota Nakada, Haruka Masuda, Haruna Sumi, Ayaka Wada, Shuuhei Hirose, Iori Aketa, Akira Kobayashi
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111906- (2023)
Summary: Melanin is a pigment produced from the amino acid L-tyrosine in melanosomes. The CNC-family transcription factor Nrf3 is expressed in the basal layer of the epidermis, where melanocytes reside, but its melanogenic function is unclear. Here,
Externí odkaz:
https://doaj.org/article/71f9bdf01e884d8aa6365d206558f4a4
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
Autor:
Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into am
Externí odkaz:
https://doaj.org/article/cf5c2b2aa01a4b1b81e53280acad9dd5
Autor:
Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103180- (2021)
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases. The genetic assoc
Externí odkaz:
https://doaj.org/article/f01b051b1dad4603bf6345ed1e1c42fa
Autor:
Tsuyoshi Waku, Akira Kobayashi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12686 (2021)
NRF3 (NFE2L3) belongs to the CNC-basic leucine zipper transcription factor family. An NRF3 homolog, NRF1 (NFE2L1), induces the expression of proteasome-related genes in response to proteasome inhibition. Another homolog, NRF2 (NFE2L2), induces the ex
Externí odkaz:
https://doaj.org/article/29b2f88d16a54e2e812af300c15cb6f1
Autor:
Takuya Azami, Ken Matsumoto, Hyojung Jeon, Tsuyoshi Waku, Masafumi Muratani, Hitoshi Niwa, Satoru Takahashi, Masatsugu Ema
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207321 (2018)
Mouse embryonic stem cells (ESCs) are pluripotent stem cells, which have the ability to differentiate into all three germ layers: mesoderm, endoderm, and ectoderm. Proper levels of phosphorylated extracellular signal-regulated kinase (pERK) are criti
Externí odkaz:
https://doaj.org/article/1072e5736745444582f84cea4374f0a8
Autor:
Shohei Oie, Kazuya Matsuzaki, Wataru Yokoyama, Shinji Tokunaga, Tsuyoshi Waku, Song-Iee Han, Naoya Iwasaki, Aya Mikogai, Kayoko Yasuzawa-Tanaka, Hiroyuki Kishimoto, Hiromi Hiyoshi, Yuka Nakajima, Toshiyuki Araki, Keiji Kimura, Junn Yanagisawa, Akiko Murayama
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 807-820 (2014)
Ribosome biosynthesis is a major intracellular energy-consuming process. We previously identified a nucleolar factor, nucleomethylin (NML), which regulates intracellular energy consumption by limiting rRNA transcription. Here, we show that, in livers
Externí odkaz:
https://doaj.org/article/de20f559a30e484c88f75979f11e7779
Autor:
Shiori Aono, Ayari Hatanaka, Atsushi Hatanaka, Yue Gao, Yoshitaka Hippo, Makoto Mark Taketo, Tsuyoshi Waku, Akira Kobayashi
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3344 (2019)
Remarkable upregulation of the NRF2 (NFE2L2)-related transcription factor NRF3 (NFE2L3) in several cancer tissues and its correlation with poor prognosis strongly suggest the physiological function of NRF3 in tumors. Indeed, we had recently uncovered
Externí odkaz:
https://doaj.org/article/e6c5a18ce504465a8d034b69b2aa4129
Autor:
Hyojung Jeon, Tsuyoshi Waku, Takuya Azami, Le Tran Phuc Khoa, Jun Yanagisawa, Satoru Takahashi, Masatsugu Ema
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150715 (2016)
Pluripotency is maintained in mouse embryonic stem (ES) cells and is induced from somatic cells by the activation of appropriate transcriptional regulatory networks. Krüppel-like factor gene family members, such as Klf2, Klf4 and Klf5, have importan
Externí odkaz:
https://doaj.org/article/083b1e49843c48dfb579b0e15ee20ea9