Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tsuyoshi Shinozuka"'
Autor:
Tsuyoshi Shinozuka
Publikováno v:
ACS Omega, Vol 6, Iss 12, Pp 8447-8455 (2021)
Externí odkaz:
https://doaj.org/article/9cb6de1063c54deaa1c2587835c8bc59
Autor:
Tsuyoshi Shinozuka
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 33196-33205 (2020)
Externí odkaz:
https://doaj.org/article/dfcf2712f6f949eaa4295e0742e56679
Autor:
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe, Kouichi Yoshinari
Publikováno v:
Drug Metabolism and Disposition. 51:67-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60456efe4bbedd2b0c9bab443faf822
https://doi.org/10.1124/dmd.122.001000
https://doi.org/10.1124/dmd.122.001000
Autor:
Narayan Karanjule, Noriyuki Hayashi, Sayaka Suzuki, Toshifumi Tsuda, Eri Tokumaru, Kyosuke Tanaka, Hiroko Kimoto, Yuki Domon, Sakiko Takahashi, Kazufumi Kubota, Yutaka Kitano, Tomihisa Yokoyama, Ryuta Koishi, Chie Fujiwara, Shinichi Inaba, Daigo Asano, Tomoko Sakakura, Kiyoshi Takasuna, Tsuyoshi Shinozuka
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd20a57b9a34b89d6090c1968a55466
https://doi.org/10.1021/acsmedchemlett.3c00079
https://doi.org/10.1021/acsmedchemlett.3c00079
Autor:
Yutaka Kitano, Tsuyoshi Shinozuka
Publikováno v:
RSC Medicinal Chemistry. 13:895-920
The relationship between preclinical in vivo efficacy and NaV1.7 coverage among three types of VGSC inhibitors is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c6d3e685e41ca45594a45b5757ebbe
https://doi.org/10.1039/d2md00081d
https://doi.org/10.1039/d2md00081d
Autor:
Daigo Asano, Syoya Hamaue, Hamim Zahir, Hideyuki Shiozawa, Yumi Nishiya, Takako Kimura, Miho Kazui, Naotoshi Yamamura, Marie Ikeguchi, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Toshiyuki Watanabe, Chizuko Yahara, Nobuaki Watanabe, Kouichi Yoshinari
Publikováno v:
Drug Metabolism and Disposition. 50:235-242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70186cea69d28e89cf0b2a4873bd0d31
https://doi.org/10.1124/dmd.121.000665
https://doi.org/10.1124/dmd.121.000665
Autor:
Kouichi Yoshinari, Nobuaki Watanabe, Daigo Asano, Tsuyoshi Shinozuka, Hideyuki Shiozawa, Shinji Murata, Takahiro Shibayama, Shin-ichi Inoue
Publikováno v:
Xenobiotica. 51:1060-1070
Nonclinical metabolite profiling of DS-1971a, a potent selective NaV1.7 inhibitor, was performed to predict human metabolites.After the oral administration of radiolabelled DS-1971a, the predominant metabolite in mouse plasma was M4, a monoxide at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6be982fb043ee68ef87e2447b7a6b5
https://doi.org/10.1080/00498254.2021.1963009
https://doi.org/10.1080/00498254.2021.1963009
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel class of estrogen-related receptor α (ERRα) agonists has been discovered. A structure–activity relationship study of high-throughput screening hits 1 and 2 led to the discovery of benzimidazole 3d (DS20362725) and acetop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff9d4a884b2f61d535dff269ad0645
https://doi.org/10.1021/acsmedchemlett.1c00100
https://doi.org/10.1021/acsmedchemlett.1c00100
Autor:
Yutaka, Kitano, Tsuyoshi, Shinozuka
Publikováno v:
RSC medicinal chemistry. 13(8)
The selective inhibition of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fe3ce44ae64ba9b39a5d21857184a88
https://pubmed.ncbi.nlm.nih.gov/36092147
https://pubmed.ncbi.nlm.nih.gov/36092147
Autor:
Yutaka Kitano, Chie Fujiwara, Sayaka Suzuki, Ryuta Koishi, Tomihisa Yokoyama, Satoshi Shibuya, Daigo Asano, Yuki Domon, Kyosuke Tanaka, Hiroko Kimoto, Akiko Shimizugawa, Tsuyoshi Shinozuka, Kazufumi Kubota, Hiroyuki Kobayashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:653-663
The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond in NaV1.7 blocker III, structure-activity relationship studies that led to the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89845e45af2cb38ea79da89f3f6a10c8
https://doi.org/10.1248/cpb.c20-00126
https://doi.org/10.1248/cpb.c20-00126