Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Tsuyoshi Sakane"'
Autor:
Naomi Yamashita, Yasuko Akimoto, Kenji Minoguchi, Kentaro Sekine, Mikio Nakajima, Yuji Okano, Ken Ohta, Tsuyoshi Sakane
Publikováno v:
Allergology International, Vol 48, Iss 1, Pp 37-42 (1999)
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinop
Externí odkaz:
https://doaj.org/article/f4f314de8fa445489b3d65f4836f22ae
Autor:
Sueshige Wakisaka, Shoso Yamamoto, Mitsuhiro Takeno, Shoji Mihara, Noboru Suzuki, Yuko Takeba, Tsuyoshi Sakane
Publikováno v:
International Archives of Allergy and Immunology. 129:175-180
Background: Defects in immune responses have been reported in patients with Behçet’s disease (BD). To further characterize the immune dysfunction and its contribution to the pathogenesis, we have studied Fas ligand (FasL) expression in peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd185b16cafb1d0c9fc8a1e2e5a89bd6
https://doi.org/10.1159/000065878
https://doi.org/10.1159/000065878
Autor:
Teruaki Oku, Tsuyoshi Sakane, Jun-ichi Kashiwakura, Mitsuhiro Takeno, Satoshi Toyoshima, Shizuo Nakajin, Saotomo Itoh, Noboru Suzuki
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:718-721
We have previously shown that Txk, a member of Tec family tyrosine kinase, is expressed in Th1 and ThO cells and directly contributes to gene transcription of Th1-related proteins, including interferon (IFN)-gamma, through nuclear translocation in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441677501211f19dce6b663ac2500dc2
https://doi.org/10.1248/bpb.25.718
https://doi.org/10.1248/bpb.25.718
Publikováno v:
Cellular Immunology. 208:34-42
Th2 cell predominance relative to Th1 cells contributes to pathological immune responses in patients with atopic asthma. IL-12 is a key cytokine in the induction of Th1 cells, and downregulation of IL-12 production is reported in these patients. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfcc3887fbd25dbf610dc404fda2d1d
https://doi.org/10.1006/cimm.2001.1759
https://doi.org/10.1006/cimm.2001.1759
Autor:
Tsuyoshi Sakane, Mitsuhiro Takeno
Publikováno v:
Expert Opinion on Investigational Drugs. 9:1993-2005
Behçet's disease is a systemic inflammatory disorder. The patients have repeated exacerbations and remissions of the symptoms. This disease may produce a wide variety of symptoms. In mild cases, mucocutaneous lesions are only the symptoms during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadf502c7767a7bfaa728ebddeda6364
https://doi.org/10.1517/13543784.9.9.1993
https://doi.org/10.1517/13543784.9.9.1993
Autor:
Noboru Suzuki, Tsuyoshi Sakane
Publikováno v:
Japanese Journal of Clinical Immunology. 23:499-504
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b870591eb21f39f8ab4447435be7e6
https://doi.org/10.2177/jsci.23.499
https://doi.org/10.2177/jsci.23.499
Spontaneous production of proinflammatory cytokines by neutrophils in patients with Behcet's disease
Publikováno v:
Ensho. 20:157-164
Neutrophil hyperfunction plays a critical role in the development and exacerbations of Behcet disease (BD) . However, precise mechanisms responsible for the neutrophil hyperfunction in this disease have been obscure. We here studied cytokine producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c30d7d75e6b04357c055e7c091f4a9
https://doi.org/10.2492/jsir1981.20.157
https://doi.org/10.2492/jsir1981.20.157
Publikováno v:
Arthritis & Rheumatism. 42:2418-2429
Objective To elucidate the possible involvement of the nervous system in the regulation of pathophysiologic responses in patients with rheumatoid arthritis (RA), we examined the expression of peripheral nerves containing the neuropeptides calcitonin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be333d1f2f51f3e4829786ac12b8cf97
https://doi.org/10.1002/1529-0131(199911)42:11<2418::aid-anr21>3.0.co
https://doi.org/10.1002/1529-0131(199911)42:11<2418::aid-anr21>3.0.co
Autor:
Takashi Hashimoto, Kimihiro Nakae, Satoru Yukawa, Manabu Mochizuki, Tsuyoshi Sakane, Midori Nishiyama, Goro Inaba
Publikováno v:
Environmental Health and Preventive Medicine. 4:130-134
The 4th nationwide epidemiological survey on Behçet disease (BD), which included all patients with BD at 1,200 hospitals selected at random from 10,081 hospitals in Japan, was carried out by the BD Research Committee of the Ministry of Health and We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add3644458e7c353ced72b4a04615c9f
https://doi.org/10.1007/bf02932268
https://doi.org/10.1007/bf02932268
Autor:
Nobuhiko Saito, Sueshige Wakisaka, Takashi Hoshino, Satoshi Suzuki, N. Sekita, Noboru Suzuki, Tsuyoshi Sakane, Shoji Mihara, Shoso Yamamoto
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:1378-1385
Apoptosis plays a critical role in the development and homeostasis of tissues, especially those with high cell turnover such as the lymphoid system. We have examined the effects of thyroid hormones, TSH and TRH, on apoptosis of human T lymphocytes. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a4a0e67ae1911b884b5967cf7e21c7
https://doi.org/10.1210/jcem.84.4.5598
https://doi.org/10.1210/jcem.84.4.5598