Výsledky vyhledávání - "Tsuyoshi Ooie"

Absorption, Metabolism, and Excretion of [14C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects

Autor: Chifuyu Toriumi, Tsuyoshi Ooie, Yoshiaki Satoh, Masahiro Miura, Satoshi Ohmori

Publikováno v: Drug Metabolism and Disposition. 35:1624-1633

The absorption, metabolism, and excretion of imidafenacin [KRP-197/ONO-8025, 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide], a new antimuscarinic drug developed for treatment of overactive bladder, were assessed in six healthy male subjects af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4391349f2428295dced9b5d19a1901cb
https://doi.org/10.1124/dmd.107.016030

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Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography–tandem mass spectrometry

Autor: Tsuyoshi Ooie, Norihiro Kanayama, Yuichi Masuda, Satoshi Ohmori, Shigeru Manita

Publikováno v: Journal of Chromatography B. 853:70-79

Imidafenacin (KRP-197/ONO-8025, IM), 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide, is a new antimuscarinic agent currently under application for the indication of treatment of overactive bladder in Japan. We developed and validated the sensit

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https://doi.org/10.1016/j.jchromb.2007.02.047

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Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry

Autor: Satoshi Ohmori, Yuichi Masuda, Norihiro Kanayama, Tsuyoshi Ooie, Shigeru Manita

Publikováno v: Biomedical Chromatography. 21:940-948

New bioanalytical methods have been developed for the determination of imidafenacin (KRP-197/ONO-8025, IM), a novel antimuscarinic drug developed for the treatment of overactive bladder, and its metabolites, M-2, M-3, M-4, M-6 and M-8 (method 1), M-5

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https://doi.org/10.1002/bmc.837

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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

Autor: Noriko Hirota, Takafumi Iwatsubo, Yuichi Sugiyama, Hiroshi Suzuki, Takashi Ishizaki, Charles A. Tyson, Kan Chiba, Noriaki Shimada, Tsuyoshi Ooie, Carol E. Green

Publikováno v: Pharmacology & Therapeutics. 73:147-171

As a new approach to predicting in vivo drug metabolism in humans, scaling of in vivo metabolic clearance from in vitro data obtained using human liver microsomes or hepatocytes is described in this review, based on the large number of literature dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f8efd626c80fc46ab932ce29d9df78
https://doi.org/10.1016/s0163-7258(96)00184-2

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PREDICTION OF IN VIVO DRUG DISPOSITION FROM IN VITRO DATA BASED ON PHYSIOLOGICAL PHARMACOKINETICS

Autor: Noriko Hirota, Hiroshi Suzuki, Tsuyoshi Ooie, Yuichi Sugiyama, Takafumi Iwatsubo

Publikováno v: Biopharmaceutics & Drug Disposition. 17:273-310

Because of the increasing availability of human liver samples we now have a greater ability to predict in vivo drug disposition and pharmacokinetics in man from in vitro metabolic and binding studies. Firstly, we review several successful attempts to

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https://doi.org/10.1002/(sici)1099-081x(199605)17:4<273::aid-bdd961>3.0.co

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[Untitled]

Autor: Tsuyoshi Ooie, Yuichi Sugiyama, Hiroshi Suzuki, Tetsuya Terasaki

Publikováno v: Pharmaceutical Research. 13:1065-1068

Purpose. An active transport system, which pumps quinolone antimicrobial agents (quinolones) from cerebrospinal fluid (CSF) to systemic blood, exists at the choroid plexus, an epithelial tissue that forms the blood-CSF barrier (BCSFB). The present st

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https://doi.org/10.1023/a:1016014909431

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[Untitled]

Autor: Yuichi Sugiyama, Tsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki

Publikováno v: Pharmaceutical Research. 13:523-527

Purpose. It is reported that the cerebrospinal fluid (CSF) to plasma unbound concentration ratio of fleroxacin at steady-state is approximately 0.5 in experimental animals. These results can be accounted for by assuming the presence of an active tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05ba0333b4658389ed94750b6dbbb000
https://doi.org/10.1023/a:1016081618149

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Kinetic analysis of the transport of the quinolone antibiotics across the blood-brain barrier and blood-CSF barrier

Autor: Tsuyoshi Ooie, Yuichi Sugiyama, Tetsuya Terasaki, Hiroshi Suzuki

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:755-758

The modified distributed model was constructed to analyze the distribution of quinolone antibiotics (NQs) in the rat brain. Eight-fold variations among NQs examined were observed for both the brain-to-plasma unbound concentration ratio (Kp, f(brain))

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https://doi.org/10.2133/dmpk.8.supplement_755

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High-performance liquid chromatographic determination of 6,8-difluoro-1-(2-fluoroethyl)-1,4- dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid and its metabolites in laboratory animals

Autor: Hisao Kusajima, Hiroshi Uchida, Fumio Kawahara, Tsuyoshi Ooie

Publikováno v: Journal of chromatography. 381(1)

A simple, sensitive and specific high-performance liquid chromatographic method for a new quinolone antimicrobial agent, 6,8-difluoro-1-(2-fluoroethyl)-1,4- dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (AM-833, I), and its meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e348cb0f748665905125e4840ba0d0
https://pubmed.ncbi.nlm.nih.gov/3095363

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