Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tsuyoshi Ohkuni"'
Autor:
Wataru Arai, Mitsuhiro Tsujiwaki, Atsushi Watanabe, Takashi Kojima, Hiroki Tanaka, Takumi Konno, Tsuyoshi Ohkuni, Shin Kikuchi, Yuji Sakuma, Yuki Kodera, Yuma Shindo, Kizuku Ohwada, Kenichi Takano, Takayuki Kohno, Maki Miyakawa
Publikováno v:
Tissue Barriers
Airway and intestinal epithelial permeability barriers are crucial in epithelial homeostasis. High mobility group box 1 (HMGB1), increased by various stimuli, is involved in the induction of airway inflammation, as well as the pathogenesis of inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef104a3133ddd66db59e8ff737d9bde
https://doi.org/10.1080/21688370.2021.1972760
https://doi.org/10.1080/21688370.2021.1972760
Autor:
Tsuyoshi Ohkuni, Masuo Kondoh, Takashi Kojima, Takayuki Kohno, Kizuku Ohwada, Ryo Miyata, Takuya Kakuki, Kenichi Takano, Masaya Nakano, Takumi Konno
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8390, p 8390 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8390, p 8390 (2021)
The airway epithelium of the human nasal mucosa acts as a physical barrier that protects against inhaled substances and pathogens via bicellular and tricellular tight junctions (bTJs and tTJs) including claudins, angulin-1/LSR and tricellulin. High m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec0b2040ad2a09025dc7c03b28e1ead
Autor:
Shin-ichi Yokota, Takayuki Kohno, Ryoto Yajima, Tsuyoshi Ohkuni, Noriko Ogasawara, Takuya Kakuki, Kenichi Takano, Takumi Konno, Ryo Miyata, Tetsuo Himi, Takashi Kojima, Shin Kikuchi, Akito Kakiuchi, Yakuto Kaneko
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Disruption of nasal epithelial tight junctions (TJs) and ciliary dysfunction are found in patients with chronic rhinosinusitis (CRS) and nasal polyps (NPs), along with an increase of p63-positive basal cells and histone deacetylase (HDAC) activity. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d78232b608292040abc58ba9f93d0c4
http://link.springer.com/article/10.1038/s41598-017-11481-w
http://link.springer.com/article/10.1038/s41598-017-11481-w
Autor:
KEISUKE YAMAMOTO, YOSHIHIRO FUJIYA, KOJI KURONUMA, NORIKO OGASAWARA, TSUYOSHI OHKUNI, SHIN-ICHI YOKOTA, SATOSHI TAKAHASHI, KENICHI TAKANO
Publikováno v:
In Vivo; Mar/Apr2022, Vol. 36 Issue 2, p918-924, 7p
Autor:
Yakuto, Kaneko, Takumi, Konno, Takayuki, Kohno, Takuya, Kakuki, Ryo, Miyata, Tsuyoshi, Ohkuni, Akito, Kakiuchi, Ryoto, Yajima, Kizuku, Ohwada, Makoto, Kurose, Tetsuo, Himi, Kenichi, Takano, Takashi, Kojima
Publikováno v:
American journal of translational research. 11(2)
Rho-kinase inhibitor Y27632, which is a factor in conditional reprogramming culture, induces airway progenitor clone formation. To investigate whether Y27632 enhances airway progenitor cells in nasal epithelium, primary cultures of HNECs transfected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c2375bd49b9a21d8fd617f411d606b0
https://pubmed.ncbi.nlm.nih.gov/30899365
https://pubmed.ncbi.nlm.nih.gov/30899365
Autor:
Takafumi Ninomiya, Tsuyoshi Ohkuni, Tamaki Okabayashi, Tetsuo Himi, Noriko Ogasawara, Norimasa Sawada, Hiroyuki Tsutsumi, Jun Fuchimoto, Nobuhiro Fujii, Tomoyuki Masaki, Satoshi Hirakawa, Masaki Murata, Takashi Kojima, Satoshi Tanaka, Akira Takasawa, Kazufumi Obata
Publikováno v:
Molecular Biology of the Cell
We established a respiratory syncytial virus (RSV)-infected model in polarized normal human nasal epithelial cells and found that the replication of RSV and the epithelial cell responses including induction of tight junctions were regulated via a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151810fbed982d0f15546e8710559ce7
https://doi.org/10.1091/mbc.e10-11-0875
https://doi.org/10.1091/mbc.e10-11-0875
Autor:
Atsushi Kondoh, Noriko Ogasawara, Norimasa Sawada, Mitsuru Go, Tsuyoshi Ohkuni, Tetsuo Himi, Takashi Kojima, Kenichi Takano, Ryuta Kamekura
Publikováno v:
Acta Oto-Laryngologica. 131:861-868
Altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (SCC) independent of human papilloma virus (HPV) infection may lead to tumor progression.Integral tight junction proteins, the claudins and tricell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abb1e5d1016201d13e4d7ebe0dbf05c
https://doi.org/10.3109/00016489.2011.562537
https://doi.org/10.3109/00016489.2011.562537
Autor:
Mitsuru Go, Tsuyoshi Ohkuni, Noriko Ogasawara, Norimasa Sawada, Tomoyuki Masaki, Takafumi Ninomiya, Shin Kikuchi, Tetsuo Himi, Kenichi Takano, Takashi Kojima
Publikováno v:
Medical Molecular Morphology. 42:204-211
Tricellulin was identified as the first marker of the tricellular tight junction, which forms at the meeting points of three cells, and it is required for the maintenance of the transepithelial barrier. Although it is also considered to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bb11b9a794903336103788767ef5e9
https://doi.org/10.1007/s00795-009-0470-y
https://doi.org/10.1007/s00795-009-0470-y
Autor:
Takayuki Kohno, Tetsuo Himi, Kenichi Takano, Takuya Kakuki, Ryo Miyata, Takumi Konno, Takashi Kojima, Tsuyoshi Ohkuni, Noriko Ogasawara, Norimasa Sawada, Kazuaki Nomura
Publikováno v:
European journal of pharmacology. 761
Human nasal epithelial cells (HNECs) are important in the tight junctional barrier and innate immune defense protecting against pathogens invading via Toll-like receptors (TLRs). MicroRNAs (miRNAs) regulate expression of tight junctions as direct or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c09529ca4185e1415e6a504f909297
https://pubmed.ncbi.nlm.nih.gov/25959385
https://pubmed.ncbi.nlm.nih.gov/25959385
Autor:
Atsushi Kondoh, Jun Fuchimoto, Noriko Ogasawara, Norimasa Sawada, Tomoyuki Masaki, Takashi Kojima, Tatsuro Shigyo, Tetsuo Himi, Kazufumi Obata, Kazuaki Nomura, Tsuyoshi Ohkuni, Naoyuki Kobayashi
Publikováno v:
American journal of rhinologyallergy. 26(6)
Background Thymic stromal lymphopoietin (TSLP) acts as a master switch for allergic inflammation and plays a key role in allergic diseases, including allergic rhinitis. Double-stranded RNA (dsRNA) recognized by Toll-like receptor 3 (TLR3) strongly ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176d6fd30eae624d765286ce614bdb3e
https://pubmed.ncbi.nlm.nih.gov/23232191
https://pubmed.ncbi.nlm.nih.gov/23232191