Výsledky vyhledávání - "Tsuyoshi Mutou"

Aplyronines D–H from the sea hare Aplysia kurodai: isolation, structures, and cytotoxicity

Autor: Yoshifumi Imamura, Tsuyoshi Mutou, Kiyoyuki Yamada, Kiyotake Suenaga, Takeshi Ishigaki, Makoto Ojika, Akira Sakakura, Hideo Kigoshi, Kohji Yoshikawa

Publikováno v: Tetrahedron. 68:982-987

Five cytotoxic macrolides, aplyronines D–H (4–8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98fc3925c1ed148e8138097e5ec39671
https://doi.org/10.1016/j.tet.2011.11.095

Zobrazit plný text záznamu

Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: isolation, structure determination, synthesis, and biological activity

Autor: Takunobu Shibata, Kiyoyuki Yamada, Takashi Itoh, Kozue Hayamizu, Tatsuya Fujita, Masaki Takagi, Tsuyoshi Mutou, Hideo Kigoshi, Kiyotake Suenaga, Taiji Irifune, Noboru Takada

Publikováno v: Tetrahedron. 60:8509-8527

The bioassay-guided fractionation of the cytotoxic constituents of the Japanese sea hare Dollabella auricularia led to the isolation of aurilide ( 1 ), a 26-membered cyclodepsipeptide. The gross structure of 1 was established by spectroscopic analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59172bfffb97df1e9e1df9d250a551dd
https://doi.org/10.1016/j.tet.2004.06.125

Zobrazit plný text záznamu

A new synthetic analogue of the bracken ultimate carcinogen: Elevation of stability and alteration of DNA alkylation site selectivity

Autor: Junko Takagi, Yukio Sugiura, Tetsuya Kusakabe, Kiyoyuki Yamada, Tsuyoshi Mutou, Hidekazu Ohashi, Yuusi Kitamura, Toshiyuki Atsumi, Daisuke Sasaki, Tatsuya Fujita, Hideo Kigoshi

Publikováno v: Tetrahedron Letters. 38:3235-3238

The benzodienone 4 as a stable analogue of the bracken ultimate carcinogen (2) has been designed and synthesized. In the reaction with DNA the compound 4 was found to give only the N-7 alkylated product of guanine and no N-3 alkylated product of aden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca5ad57ef2a11972af321602886fa8fb
https://doi.org/10.1016/s0040-4039(97)00572-8

Zobrazit plný text záznamu

Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia

Autor: Kiyoyuki Yamada, Takahiro Shibata, Takashi Itoh, Tsuyoshi Mutou, Kiyotake Suenaga, Hideo Kigoshi

Publikováno v: Tetrahedron Letters. 37:6771-6774

Aurilide ( 1 ), a new 26-membered cyclodepsipeptide, has been isolated from the Japanese sea hare Dolabella auricularia . The gross structure of 1 was established by spectroscopic analysis. The absolute stereostructure of 1 was determined by HPLC ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae5bcae3782065bab4a6ad23ecf4cea4
https://doi.org/10.1016/s0040-4039(96)01464-5

Zobrazit plný text záznamu

Synthesis of dolastatin G and nordolastatin G, cytotoxic 35-membered cyclodepsipeptides of marine origin

Autor: Takashi Kondo, Kiyoyuki Yamada, Tsuyoshi Mutou, Makoto Ojika, Hideo Kigoshi, Takunobu Shibata

Publikováno v: Tetrahedron Letters. 37:7299-7302

The synthesis of dolastatin G (1) and nordolastatin G (2), new cytotoxic cyclodepsipeptides from the Japanese sea hare Dolabella auricularia, was achieved enantioselectively, and the present result confirmed their stereostructures unambiguously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9965e01ae6e09b2aab307eaa56f855a
https://doi.org/10.1016/0040-4039(96)01653-x

Zobrazit plný text záznamu

Aplyronine A, a Potent Antitumor Substance of Marine Origin, Aplyronines B and C, and Artificial Analogues: Total Synthesis and Structure−Cytotoxicity Relationships

Autor: Tsuyoshi Mutou, Kiyotake Suenaga, Hiroyuki Ishiwata, Hideo Kigoshi, Akira Sakakura, Makoto Ojika, Takeshi Ogawa, Toshiyuki Atsumi, Takeshi Ishigaki, Kiyoyuki Yamada

Publikováno v: The Journal of Organic Chemistry. 61:5326-5351

The enantioselective total synthesis of aplyronine A (1), a potent antitumor substance of marine origin, was achieved by a convergent approach. Three segments 4, 5, and 6, corresponding to the C5−C11, C21−C27, and C28−C34 portions of aplyronine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1646d8c65fefc6e5f1504e472ddc679
https://doi.org/10.1021/jo9606113

Zobrazit plný text záznamu

Synthetic Studies on Aplyronine A, a Potent Antitumor Substance of Marine Origin: Stereocontrolled Synthesis of the C21–C34 Segment

Autor: Tsuyoshi Mutou, Makoto Ojika, Takeshi Ogawa, Kiyoyuki Yamada, Junko Hirano, Hideo Kigoshi, Akira Sakakura, Kiyotake Suenaga, Masanori Nisiwaki

Publikováno v: Tetrahedron Letters. 35:1247-1250

The C21–C34 segment 2 of aplyronine A (1), a potent antitumor substance of marine origin, was synthesized enantioselectively in 25 steps (17% overall yield) from imide 11.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e00d50810dd7cd3902b33df14a04479
https://doi.org/10.1016/0040-4039(94)88035-2

Zobrazit plný text záznamu

ChemInform Abstract: Isolation and Stereostructure of Aurilide, a Novel Cyclodepsipeptide from the Japanese Sea Hare Dolabella auricularia

Autor: Kiyotake Suenaga, Kiyoyuki Yamada, Takahiro Shibata, Takashi Itoh, Tsuyoshi Mutou, Hideo Kigoshi

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d9f63e3dda46a8ac20bb18ce78ad948
https://doi.org/10.1002/chin.199651183

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání