Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tsuyoshi Kajihara"'
Publikováno v:
Journal of Gastroenterology and Hepatology. 14:578-582
Background: Several organic anions cause dissociation of biliary lipid secretion from bile acid secretion (uncoupling). As bile lipids originate from liver microsomes and are transported by carrier proteins and/or transcytotic vesicles, such a reduct
Publikováno v:
Journal of Gastroenterology. 35:450-455
We recently demonstrated that several organic anions cause dissociation of biliary lipid secretion from that of bile acids; namely, the "uncoupling phenomenon," in association with changes in the phospholipid molecular species in the canalicular memb
Autor:
Hidenori Ochi, Yasushi Sunami, Tsuyoshi Kajihara, Shigeyuki Yasumiba, Goro Kajiyama, Kuniharu Nakai, Gunji Yamashita, Kazuhiko Tsuboi, Yoshihiro Hattori, Hideyuki Hyogo, Yasumasa Asamoto, Minoru Sakomoto, Tomoji Nishioka, Susumu Tazuma
Publikováno v:
Digestive Diseases and Sciences. 45:1413-1421
Phospholipase A2 plays a role in cholesterol gallstone development by hydrolyzing bile phospholipids into lysolecithin and free fatty acids. Lysolecithin and polyunsaturated free fatty acids are known to stimulate the synthesis and/or secretion of ga
Autor:
Hiroaki Miyake, Taiji Matsumoto, Shigeyoshi Ohguri, Hiroyuki Miura, Toshiyuki Mizuno, Shigeyuki Yasumiba, Hidenori Ochi, Ken Adachi, Fumio Omata, Gunji Yamashita, Yasushi Sunami, Hisao Shibata, Goro Kajiyama, Fumiaki Ueno, Fumio Sugata, Tomoji Nishioka, Susumu Tazuma, Yoshihiro Hattori, Hideyuki Hyogo, Akio Abe, Tsuyoshi Kajihara, Shigehiro Kokubu
Publikováno v:
Journal of Clinical Gastroenterology. 26:287-291
Inhibitors of 3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase have been reported to decrease the cholesterol saturation index (CSI) in duodenal bile in humans and to prevent formation of cholesterol gallstones in animal studies. We performe
Autor:
Tomoji Nishioka, Hideyuki Hyogo, Hiroaki Miyake, Goro Kajiyama, Susumu Tazuma, Yasushi Sunami, Tsuyoshi Kajihara, Shigeyuki Yasumiba, Hiroyuki Miura, Gunji Yamashita, Yoshihiro Hattori, Hidenori Ochi
Publikováno v:
Clinical Therapeutics. 20:477-485
The use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors has become common in the treatment of hypercholesterolemia. The present uncontrolled study was undertaken to determine the effect of cerivastatin sodium (BAY w 6228), a n
Autor:
Hideyuki Hyogo, Sumie Hatsushika, Susumu Tazuma, Gunji Yamashita, Tomoji Nishioka, Yasushi Sunami, Yoshihiro Hattori, Hiroaki Miyake, Hidenori Ochi, Hiroyuki Miura, Goro Kajiyama, Shigeyuki Yasumiba, Denya Tsuchimoto, Tsuyoshi Kajihara
Publikováno v:
Hepatology Research. 9:218-223
Lecithin–cholesterol vesicles are present in bile and play a role in cholesterol metastability. Cholesterol holding capacity of vesicles is regulated by lecithin hydrophobicity. In the present study, the effect of therapeutic bile salts on biliary
Autor:
Hiroaki Miyake, Hideyuki Hyogo, Denya Tsuchimoto, Tomoji Nishioka, Hiroyuki Miura, Naomichi Hirano, Goro Kajiyama, Gunji Yamashita, Yoshihiro Hattori, Tsuyoshi Kajihara, Susumu Tazuma
Publikováno v:
International Hepatology Communications. 6:191-198
Organic anions can uncouple bile salt secretion from the secretion of phospholipid and cholesterol. The uncoupling mechanism appears to be dependent on the type of anion present. To investigate the effect that different uncoupling mechanisms may have
Autor:
Shinichiro Sugiyama, Hirokazu Goishi, Toshio Miura, Morihisa Akagi, Tsuyoshi Kajihara, Tomotaka Tanaka
Publikováno v:
BMC Gastroenterology
Background Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics. Among these medications, corticosteroids in children and adole
Autor:
Kuniharu Nakai, Hidenori Ochi, Goro Kajiyama, Yasushi Sunami, Hideyuki Hyogo, Susumu Tazuma, Yasumasa Asamoto, Tsuyoshi Kajihara, Kazuhiko Tsuboi, Minoru Sakomoto, Shigeyuki Yasumiba
Publikováno v:
Journal of clinical gastroenterology. 31(3)
Ninety-six patients treated successively for symptomatic cholelithiasis with extracorporeal shock wave lithotripsy (ESWL) and oral bile acid therapy consisting of ursodeoxycholic acid in daily dosages of 600 mg were prospectively followed for gallsto
Autor:
Hideyuki Hyogo, Yoshihiro Hattori, Tsuyoshi Kajihara, Hiroaki Miyake, Tomoji Nishioka, Denya Tsuchimoto, Goro Kajiyama, Naomichi Hirano, Seiji Nakao, Hiroyuki Miura, Susumu Tazuma, Gunji Yamashita
Publikováno v:
Journal of gastroenterology and hepatology. 12(11)
A novel fat absorption test to clarify the malabsorption syndrome was developed using a micronephelometric technique and compared with the classic conventional technique using 131 I-triolein. An integrity of time-sequential light scattered from chylo