Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tsuyoshi Iwanaga"'
Autor:
Kathryn L. Lovero, Tsuyoshi Iwanaga, Masaki Fukata, Atsushi Watanabe, Ryuichi Shigemoto, Norihiko Yokoi, Katsuhiko Tabuchi, Roger A. Nicoll, Yuko Fukata
Publikováno v:
Proceedings of the National Academy of Sciences. 107:3799-3804
Epilepsy is a devastating and poorly understood disease. Mutations in a secreted neuronal protein, leucine-rich glioma inactivated 1 (LGI1), were reported in patients with an inherited form of human epilepsy, autosomal dominant partial epilepsy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da599f07899a779851f0ac73edb64d11
https://doi.org/10.1073/pnas.0914537107
https://doi.org/10.1073/pnas.0914537107
Autor:
Hideki Tani, Ryouhei Tsutsumi, Naoki Hosomi, Hiroko Iwanari, Naoto Matsuda, Tsuyoshi Iwanaga, Yoshiharu Matsuura, Jun Noritake, Masaki Fukata, Takao Hamakubo, Yasuhiro Mochizuki, Yuko Fukata, David S. Bredt, Tatsuhiko Kodama
Publikováno v:
The Journal of Cell Biology
Protein palmitoylation is the most common posttranslational lipid modification; its reversibility mediates protein shuttling between intracellular compartments. A large family of DHHC (Asp-His-His-Cys) proteins has emerged as protein palmitoyl acyltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef83d1b84e64b7d9bf369f5b031332a
https://doi.org/10.1083/jcb.200903101
https://doi.org/10.1083/jcb.200903101
Publikováno v:
Progress in Lipid Research. 48:117-127
Protein S-palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating protein trafficking and function. The unique reversibility of protein palmitoylation allows proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d95dc5cb33bcde1112a35f87965c83
https://doi.org/10.1016/j.plipres.2009.02.001
https://doi.org/10.1016/j.plipres.2009.02.001
Publikováno v:
Molecular and Cellular Biology. 29:435-447
The heterotrimeric G protein alpha subunit (Galpha) is targeted to the cytoplasmic face of the plasma membrane through reversible lipid palmitoylation and relays signals from G-protein-coupled receptors (GPCRs) to its effectors. By screening 23 DHHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074bbcf325ba6c497cc4ad2c9649b358
https://doi.org/10.1128/mcb.01144-08
https://doi.org/10.1128/mcb.01144-08
Autor:
David S. Bredt, Masaki Fukata, Roger A. Nicoll, Tsuyoshi Iwanaga, Hillel Adesnik, Yuko Fukata
Publikováno v:
Science. 313:1792-1795
Abnormally synchronized synaptic transmission in the brain causes epilepsy. Most inherited forms of epilepsy result from mutations in ion channels. However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc7983447a3bb1fdac520181e76da4b
https://doi.org/10.1126/science.1129947
https://doi.org/10.1126/science.1129947
Autor:
Mark E. Ewen, Jennifer L. Hunt, Massimo Loda, Roderick T. Bronson, Chiaki Takahashi, Makoto Noda, Anke Bakker, Tsuyoshi Iwanaga, Yujiro Takegami, Bernardo Contreras
Publikováno v:
Nature Genetics. 38:118-123
Mutations in the gene encoding the retinoblastoma tumor suppressor predispose humans and mice to tumor development. Here we have assessed the effect of Nras loss on tumor development in Rb1 heterozygous mice. Loss of one or two Nras alleles is shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6432961b5bd4b00f9b4ac531adf41174
https://doi.org/10.1038/ng1703
https://doi.org/10.1038/ng1703
Publikováno v:
International Congress Series. 1233:151-156
The conversion of l -arginine (Arg) to Nω-hydroxy- l -arginine (OH-Arg) and further to l -citrulline (Cit) in one cycle of the reaction of purified rat neuronal nitric oxide synthase (nNOS) was measured with the reaction rapid-quenching method using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d294e8d82989ac9ccfececceddef17
https://doi.org/10.1016/s0531-5131(02)00510-1
https://doi.org/10.1016/s0531-5131(02)00510-1
Immobilization of γ-glutamyl transpeptidase, a membrane enzyme, in gel beads via liposome entrapment
Publikováno v:
Journal of Fermentation and Bioengineering. 77:268-273
Bovine kidney γ-glutamyl transpeptidase, a membrane enzyme, was immobilized in gel beads by application of the method of Wallsten et al . (Biochim. Biophys. Acta, 982, 47–52, 1989). The gel beads were equilibrated with a dispersion of the enzyme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d87c7c8336e681664cfa6db5dd77546
https://doi.org/10.1016/0922-338x(94)90232-1
https://doi.org/10.1016/0922-338x(94)90232-1
Publikováno v:
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 52(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5091ea7a13b41c5be3771820850f63aa
https://pubmed.ncbi.nlm.nih.gov/17491326
https://pubmed.ncbi.nlm.nih.gov/17491326
Publikováno v:
Methods (San Diego, Calif.). 40(2)
Posttranslational modifications, including phosphorylation, ubiquitination and lipid modifications, provide proteins with additional functions and regulation beyond genomic information. Palmitoylation is a reversible lipid modification with palmitic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9782f1d70ffbf12768a8c65bcb9217c9
https://pubmed.ncbi.nlm.nih.gov/17012030
https://pubmed.ncbi.nlm.nih.gov/17012030