Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tsuyoshi Irie"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:229-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559d62b56c1646fc9d75549474b19e6f
https://doi.org/10.2133/dmpk.13.229
https://doi.org/10.2133/dmpk.13.229
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:237-251
The metabolism of NKH477 by the rat liver 9000×g supernatant was investigated. Also the metabolites of NKH477 in plasma, tissue, urine, feces and bile were analyzed after intravenous administration of 14C-NKH477 to rats and dogs or NKH477 to human.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd196a6b083205df8b3fa2640e37c187
https://doi.org/10.2133/dmpk.13.237
https://doi.org/10.2133/dmpk.13.237
Autor:
Kouwa Yamashita, Shin-ichi Ninomiya, Matsuo Takaichi, Yoshio Esumi, Tsuyoshi Irie, Shin-ichi Matsumoto, Miwa Ootubo, Atsushi Takao, Toshiko Eki, Hideaki Seki
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:221-228
The blood concentration, distribution and excretion of radioactivity were investigated in male rats after daily intravenous administration of 14C-NKH477 for 21 days. The effects of NKH477 on hepatic drug metabolizing enzyme system were also investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e9ca574c86051baba8f3a4ee3f2aa98
https://doi.org/10.2133/dmpk.13.221
https://doi.org/10.2133/dmpk.13.221
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:207-220
The pharmacokinetics, distribution and excretion of NKH477, a novel water-soluble forskolin derivative, improving acute cardiac failure, were investigated in rats and dogs after a single intravenous administration of 14C-labeled NKH477 and unlabeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8005eb1464f36f6abf1090ad7a41636
https://doi.org/10.2133/dmpk.13.207
https://doi.org/10.2133/dmpk.13.207
Publikováno v:
Life sciences. 61(25)
The mechanisms of the antidepressant activity of forskolin and a novel water soluble forskolin analog (NKH477) were studied using the forced swimming method in rats. Forskolin (0.01–0.1 mg/kg) and NKH477 (0.01–0.1 mg/kg) dose-dependently decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07324948211b6de8e11493ec76fe352e
https://pubmed.ncbi.nlm.nih.gov/9416762
https://pubmed.ncbi.nlm.nih.gov/9416762
Autor:
Yutaka Hashimoto, Masato Suwa, Yumi Nakai, Tsuyoshi Irie, Youko Nakamaki, Masataka Ishibashi, Norio Natsume, Syun-ichi Kametani
Publikováno v:
Drug Metabolism and Pharmacokinetics. 1:103-122
Etoposide {4'-demethylepipodophyllotoxin-9 (4, 6-O-ethylidene-β-D-glucopyranoside)}, an anticancer drug, is a semisynthetic derivative of podophyllotoxin, and it is claimed to be effective in a lung and testis cancer and in lymphoma. We have studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b633c6b13685b36314cc468fd0041bf
https://doi.org/10.2133/dmpk.1.103
https://doi.org/10.2133/dmpk.1.103
Publikováno v:
YAKUGAKU ZASSHI. 106:900-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d9db8d2452d1e4adf3cbe9df6306c7
https://doi.org/10.1248/yakushi1947.106.10_900
https://doi.org/10.1248/yakushi1947.106.10_900
Autor:
Masataka Ishibashi, Youko Nakamaki, Gen-ichi Izu, Norio Natsume, Yumi Nakai, Tsuyoshi Irie, Mitsuko Ochiai, Yutaka Hashimoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 1:123-142
Etoposide {4'-demethylepipodophyllotoxin-9 (4, 6-O-ethylidene-β-D-glucopyranoside)}, an anticancer drug, is a semisynthetic derivative of podophyllotoxin, and it is claimed to be effective in a lung and testis cancer and in a lymphoma. We have synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2dbf313624dcf600ab6290a7028552
https://doi.org/10.2133/dmpk.1.123
https://doi.org/10.2133/dmpk.1.123
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 497:169-180
A liquid chromatographic-atmospheric pressure ionization mass spectrometric method has been developed for the analysis of toremifene metabolites in human urine after oral administration. This ionization source is a useful device for studying metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44143a13770af85fb8a72cf7b89baf6
https://doi.org/10.1016/0378-4347(89)80016-7
https://doi.org/10.1016/0378-4347(89)80016-7
Publikováno v:
The Journal of the Society of Chemical Industry, Japan. 69:980-985
核置換安息香酸ビニルを合成し, その単独重合および共重合を行なった。置換体はp - メトキシ安息香酸ビニル( p-CH3O ) , p - メチル安息香酸ビニル(p-CH3),安息香酸ビニル,p-クロル安息香酸ビ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2fcea985c6d7ff98854f1484f57e5bf
https://doi.org/10.1246/nikkashi1898.69.5_980
https://doi.org/10.1246/nikkashi1898.69.5_980