Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Tsuyoshi Inoshita"'
Autor:
Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105476- (2022)
Summary: Some Parkinson’s disease (PD)-causative/risk genes, including the PD-associated kinase leucine-rich repeat kinase 2 (LRRK2), are involved in membrane dynamics. Although LRRK2 and other PD-associated genes are believed to regulate synaptic
Externí odkaz:
https://doaj.org/article/2f20268e8c1246de8b9fcb7023d5cab0
Autor:
Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Osamu Sano, Hidehisa Iwata, Kei-ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial
Externí odkaz:
https://doaj.org/article/71dca2e2970b4054b12d8d0ff385f488
Autor:
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 218-227 (2017)
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150Glue
Externí odkaz:
https://doaj.org/article/85235ce739fc410eb83359e049f8ca99
Autor:
Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing c
Externí odkaz:
https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f
Publikováno v:
Bio-Protocol, Vol 7, Iss 23 (2017)
Axonal transport, which is composed of microtubules, motor proteins and a variety of types of cargo, is a prominent feature of neurons. Monitoring these molecular dynamics is important to understand the biological processes of neurons as well as neur
Externí odkaz:
https://doaj.org/article/a32cd41fb78f4924b292f784daf392ee
Autor:
Tsuyoshi Inoshita, Yuzuru Imai
Publikováno v:
AIMS Molecular Science, Vol 2, Iss 4, Pp 461-475 (2015)
The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling. Synaptic ve
Externí odkaz:
https://doaj.org/article/3e451d9eee294e80aede579096bdf52a
Autor:
Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005503 (2015)
Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson's disease (PD). We have identified two novel LRRK2-associated proteins, a HECT-type ubiquitin ligase, HERC2, and an adaptor-like protein w
Externí odkaz:
https://doaj.org/article/715ded3cb98a4c34aa4c641abed42e56
Autor:
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004861 (2014)
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondri
Externí odkaz:
https://doaj.org/article/fe100669f56a46c7950072279f3e37e0
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004391 (2014)
Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphoryl
Externí odkaz:
https://doaj.org/article/6d8e6502b33f4074af0b9c0746866e49
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19770 (2011)
Pheromonal communication is crucial with regard to mate choice in many animals including insects. Drosophila melanogaster flies produce a pheromonal bouquet with many cuticular hydrocarbons some of which diverge between the sexes and differently affe
Externí odkaz:
https://doaj.org/article/0b5ae18371de47b69ed27403f09459d5