Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Tsuyoshi Ikura"'
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-7 (2023)
Abstract Background DNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of genetic material. DNA damage, such as DNA double-strand breaks (DSBs), triggers a response
Externí odkaz:
https://doaj.org/article/8289c03582f54b519d4a33c3c99d777c
Autor:
Kyoko Ochiai, Hiroki Shima, Tsuyoshi Ikura, Marissa C. Franke, Evelyn P. Sievert, Roger Sciammas, Kazuhiko Igarashi
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100633- (2021)
Summary: Molecular-level understanding of plasma cell (PC) differentiation has been modeled using lipopolysaccharide (LPS) stimulation in vitro. However, this system does not involve the B-cell receptor (BCR)—a critical component of B cell biology.
Externí odkaz:
https://doaj.org/article/fc80430e7afc47888d26151c9fa9ea0f
Autor:
Jiying Sun, Lin Shi, Aiko Kinomura, Atsuhiko Fukuto, Yasunori Horikoshi, Yukako Oma, Masahiko Harata, Masae Ikura, Tsuyoshi Ikura, Roland Kanaar, Satoshi Tashiro
Publikováno v:
eLife, Vol 7 (2018)
Chromosomal translocations are hallmarks of various types of cancers and leukemias. However, the molecular mechanisms of chromosome translocations remain largely unknown. The ataxia-telangiectasia mutated (ATM) protein, a DNA damage signaling regulat
Externí odkaz:
https://doaj.org/article/7d76dfc60db74112bd8e5db6c97f123b
Autor:
Takeshi Wakida, Masae Ikura, Kenji Kuriya, Shinji Ito, Yoshiharu Shiroiwa, Toshiyuki Habu, Takuo Kawamoto, Katsuzumi Okumura, Tsuyoshi Ikura, Kanji Furuya
Publikováno v:
eLife, Vol 6 (2017)
Genotoxic stress causes proliferating cells to activate the DNA damage checkpoint, to assist DNA damage recovery by slowing cell cycle progression. Thus, to drive proliferation, cells must tolerate DNA damage and suppress the checkpoint response. How
Externí odkaz:
https://doaj.org/article/24020094897e44068e56559515ee3845
Autor:
Junya Unno, Akiko Itaya, Masato Taoka, Koichi Sato, Junya Tomida, Wataru Sakai, Kaoru Sugasawa, Masamichi Ishiai, Tsuyoshi Ikura, Toshiaki Isobe, Hitoshi Kurumizaka, Minoru Takata
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1039-1047 (2014)
The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand cr
Externí odkaz:
https://doaj.org/article/e36387d2c5d74315a6dd602ff2eac987
Autor:
Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar, Satoshi Tashiro
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13554 (2010)
Chromosome translocations induced by DNA damaging agents, such as ionizing radiation and certain chemotherapies, alter genetic information resulting in malignant transformation. Abrogation or loss of the ataxia-telangiectasia mutated (ATM) protein, a
Externí odkaz:
https://doaj.org/article/5f6bb64d65bb4b7eb2118b0fc31cd508
Publikováno v:
Mol Cell Biol
NAD(+) synthesis is a fundamental process in living cells. The effects of local metabolite production on chromatin influence the epigenetic status of chromatin in DNA metabolism. We have previously shown that K5 acetylation of H2AX by TIP60 is requir
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms.
H2AX is a histone H2A variant that becomes phosphorylated upon genotoxic stress. The phosphorylated H2AX (γ-H2AX) plays an antioncogenic role in the DNA damage response and its foci patterns are highly variable, in terms of intensities and sizes. Ho
Publikováno v:
Molecular and Cellular Biology. 42
Autor:
Kaoru Sugasawa, Mayumi Yuasa-Sunagawa, Masayuki Kusakabe, Wataru Sakai, Masae Ikura, Takeshi Matsui, Masayuki Yokoi, Jun-ichi Akagi, Fumio Hanaoka, Yuki Kaneko, Nicolas Huyghe, Aiko Kishimoto, Tsuyoshi Ikura
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The ubiquitin–proteasome system (UPS) plays crucial roles in regulation of various biological processes, including DNA repair. In mammalian global genome nucleotide excision repair (GG-NER), activation of the DDB2-associated ubiquitin ligase upon U