Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Tsuyoshi, Shuto"'
Autor:
Ryoko Sasaki, Mary Ann Suico, Keisuke Chosa, Yuriko Teranishi, Takashi Sato, Asuka Kagami, Shunsuke Kotani, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto, Tomohiro Yamashita, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 1, Pp 54-62 (2023)
Hereditary ATTR amyloidosis is caused by the point mutation in serum protein transthyretin (TTR) that destabilizes its tetrameric structure to dissociate into monomer. The monomers form amyloid fibrils, which are deposited in peripheral nerves and or
Externí odkaz:
https://doaj.org/article/73aa628980de4100b6bdb344612c5194
Autor:
Noriki Takahashi, Ryunosuke Nakashima, Aoi Nasu, Megumi Hayashi, Haruka Fujikawa, Taisei Kawakami, Yuka Eto, Tomoki Kishimoto, Ayami Fukuyama, Choyo Ogasawara, Keisuke Kawano, Yukio Fujiwara, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 30 (2023)
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary condition characterized by bronchitis, emphysema, and mucus stasis. Due to the variability in symptoms among patients, traditional approaches to treating COPD as a singular disease a
Externí odkaz:
https://doaj.org/article/429d4f2c1e6347a3864b86644b249303
Autor:
Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 37-45 (2022)
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic t
Externí odkaz:
https://doaj.org/article/a3fdda52c3ac4d2197ce82bec8cd299c
Autor:
Yoshio Nakano, Masataka Moriuchi, Yutaro Fukushima, Kyotaro Hayashi, Mary Ann Suico, Hirofumi Kai, Go Koutaki, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 3, Pp 241-252 (2021)
Caenorhabditis elegans is a model organism widely used for longevity studies. Current advances have been made in the methods that allow automated monitoring of C. elegans behavior. However, ordinary manual assays as well as automated methods have yet
Externí odkaz:
https://doaj.org/article/81aea7d4b5fb4320bc6e646f27e1383d
Autor:
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve n
Externí odkaz:
https://doaj.org/article/d6c03b25c7634eeda9e0874c08df981e
Autor:
Yuya Sannomiya, Shota Kaseda, Misato Kamura, Hiroshi Yamamoto, Hiroyuki Yamada, Masataka Inamoto, Jun Kuwazuru, Saki Niino, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai
Publikováno v:
Renal Failure, Vol 43, Iss 1, Pp 510-519 (2021)
Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glom
Externí odkaz:
https://doaj.org/article/28d44a4ee9d64770bbe74e7703793f73
Autor:
Shingo Suzuki, Keisuke Chosa, Cristina Barillà, Michael Yao, Orsetta Zuffardi, Hirofumi Kai, Tsuyoshi Shuto, Mary Ann Suico, Yuet W. Kan, R. Geoffrey Sargent, Dieter C. Gruenert
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Background: Gene correction via homology directed repair (HDR) in patient-derived induced pluripotent stem (iPS) cells for regenerative medicine are becoming a more realistic approach to develop personalized and mutation-specific therapeutic strategi
Externí odkaz:
https://doaj.org/article/98771079d2134f55b64cdc7d8d0cd6f4
Autor:
Misato Kamura, Tomohiko Yamamura, Kohei Omachi, Mary Ann Suico, Kandai Nozu, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Kazumoto Iijima, Hirofumi Kai
Publikováno v:
Kidney International Reports, Vol 5, Iss 5, Pp 718-726 (2020)
Introduction: Alport syndrome is a hereditary glomerulonephritis that results from the disruption of collagen α345(IV) heterotrimerization caused by mutation in COL4A3, COL4A4 or COL4A5 genes. Many clinical studies have elucidated the correlation be
Externí odkaz:
https://doaj.org/article/bdf5f8fc4dca439b84ccb1b4dfed6dc8
Autor:
Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 113-119 (2019)
Pulmonary emphysema, inflammation and senescence-like phenotype are pathophysiological characteristics of chronic obstructive pulmonary disease (COPD). Recently, a murine model of COPD has been established by inducing airway-specific overexpression o
Externí odkaz:
https://doaj.org/article/9dba2af5bc884f9f9a2c4e0d58be15c4
Autor:
Keiko Ueno-Shuto, Shunsuke Kamei, Megumi Hayashi, Ayami Fukuyama, Yuji Uchida, Naofumi Tokutomi, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7748 (2022)
Cystic fibrosis (CF) is a hereditary disease typically characterized by infection-associated chronic lung inflammation. The persistent activation of toll-like receptor (TLR) signals is considered one of the mechanisms for the CF hyperinflammatory phe
Externí odkaz:
https://doaj.org/article/9bfeab836f0445c4b8ca8854f92857e6