Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Tsutomu Shinohara"'
Autor:
Hiroyuki Kozai, Hirokazu Ogino, Atsushi Mitsuhashi, Na Thi Nguyen, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Sato, Masaki Hanibuchi, Tsutomu Shinohara, Hiroshi Nokihara, Yasuhiko Nishioka
Publikováno v:
Thoracic Cancer, Vol 15, Iss 5, Pp 369-378 (2024)
Abstract Background Immune checkpoint inhibitors (ICIs) are a revolutionary paradigm in the treatment of thoracic malignancies and chemoimmunotherapy is a current standard care in this field. Chemotherapeutic agents are known to induce not only direc
Externí odkaz:
https://doaj.org/article/3b039c22a72a49ee860a78baa3226a06
Autor:
Eiji Takeuchi, Hirokazu Ogino, Kensuke Kondo, Yoshio Okano, Seiya Ichihara, Michihiro Kunishige, Naoki Kadota, Hisanori Machida, Nobuo Hatakeyama, Keishi Naruse, Hiroshi Nokihara, Tsutomu Shinohara, Yasuhiko Nishioka
Publikováno v:
Thoracic Cancer, Vol 15, Iss 3, Pp 248-257 (2024)
Abstract Background An increased relative eosinophil count (REC) has potential as a predictive biomarker for a beneficial clinical response and outcome to cancer immunotherapies. Therefore, the present study investigated the impact of an increased po
Externí odkaz:
https://doaj.org/article/8dd6b6ab412644d4845bdcd09c66afdf
Autor:
Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human P
Externí odkaz:
https://doaj.org/article/77e16fe3567e4a3f89266732e6c31cf1
Autor:
Eiji Takeuchi, Kensuke Kondo, Yoshio Okano, Seiya Ichihara, Michihiro Kunishige, Naoki Kadota, Hisanori Machida, Nobuo Hatakeyama, Keishi Naruse, Hirokazu Ogino, Hiroshi Nokihara, Tsutomu Shinohara, Yasuhiko Nishioka
Publikováno v:
Thoracic Cancer, Vol 14, Iss 30, Pp 3042-3050 (2023)
Abstract Background The peripheral blood eosinophil count prior to treatment has potential as a predictive biomarker for a beneficial clinical response to cancer immunotherapies. Therefore, the present study investigated the impact of the eosinophil
Externí odkaz:
https://doaj.org/article/83c945d99b1141fba1983672df71bb1f
Autor:
Michihiro Kunishige, Seiya Ichihara, Naoki Kadota, Yoshio Okano, Hisanori Machida, Nobuo Hatakeyama, Keishi Naruse, Tsutomu Shinohara, Eiji Takeuchi
Publikováno v:
Thoracic Cancer, Vol 14, Iss 4, Pp 423-426 (2023)
Abstract Lung cancer with complex epidermal growth factor receptor (EGFR) and CTNNB1 comutations is rare, and the efficacy of tyrosine kinase inhibitors (TKIs) is generally poor. Here, we encountered a lung cancer patient with complex EGFR (L858R and
Externí odkaz:
https://doaj.org/article/65ef78b1a94042eda7bab7c25b105acf
Autor:
Maho Suzukawa, Ken Ohta, Yuma Fukutomi, Hiroya Hashimoto, Takeo Endo, Masahiro Abe, Yosuke Kamide, Makoto Yoshida, Yoshihiro Kikuchi, Toshiyuki Kita, Kenji Chibana, Yasushi Tanimoto, Kentaro Hyodo, Shohei Takata, Toshiya Inui, Masahide Yasui, Yoshinori Harada, Toshio Sato, Yumi Sakakibara, Yoshiaki Minakata, Yoshikazu Inoue, Shinji Tamaki, Tsutomu Shinohara, Kazutaka Takami, Motofumi Tsubakihara, Masahide Oki, Kentaro Wakamatsu, Masahide Horiba, Gen Ideura, Koko Hidaka, Akiko M. Saito, Nobuyuki Kobayashi, Masami Taniguchi
Publikováno v:
Allergology International, Vol 72, Iss 1, Pp 63-74 (2023)
Background: Asthma is a heterogeneous disease, and phenotyping can facilitate understanding of disease pathogenesis and direct appropriate asthma treatment. This nationwide cohort study aimed to phenotype asthma patients in Japan and identify potenti
Externí odkaz:
https://doaj.org/article/7dcd4202fb214753b0a270b79d3906c2
Autor:
Seiya Ichihara, Michihiro Kunishige, Naoki Kadota, Yoshio Okano, Hisanori Machida, Nobuo Hatakeyama, Keishi Naruse, Tsutomu Shinohara, Eiji Takeuchi
Publikováno v:
Thoracic Cancer, Vol 14, Iss 1, Pp 81-84 (2023)
Abstract Immune‐related adverse events (irAEs) occur in rare cases, even after the completion of immune checkpoint inhibitor (ICI) therapy. We encountered a lung cancer patient diagnosed with acute‐onset type 1 diabetes mellitus (DM) 7 months aft
Externí odkaz:
https://doaj.org/article/1e5c3c20e6c64a928eb1dcc5ae180fcc
Autor:
Junki Terada, Yuko Toyoda, Eiji Takeuchi, Nobuyuki Tanida, Satoshi Ito, Kenji Yorita, Hisashi Matsuoka, Hiroki Bando, Yutaka Morita, Yuri Okamoto, Tsutomu Shinohara
Publikováno v:
Thoracic Cancer, Vol 13, Iss 23, Pp 3415-3419 (2022)
Abstract An 83‐year‐old Japanese man visited our hospital with dyspnea and general fatigue. Computed tomography (CT) revealed a tumor in the anterior mediastinum, bilateral pleural effusion, pericardial fluid, and multiple liver nodules. We perfo
Externí odkaz:
https://doaj.org/article/9a585815c85242d48f73c679bef61a3d
Autor:
Jan-Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R. Mumbach, Fan Zhang, Ramesh V. Nair, Joseph Nasser, Daniel H. Mai, Shalina Taylor, Lingli Wang, Ross J. Metzger, Howard Y. Chang, Jesse M. Engreitz, Michael P. Snyder, Marlene Rabinovitch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors studied pulmonary arterial endothelial cells (PAEC) under laminar shear stress and show that this physiologic condition markedly changes chromatin accessibility at regulatory regions, when compared to cells grown in a static state. T
Externí odkaz:
https://doaj.org/article/dd0de669b721470b8265ca8d188386af
Autor:
Mika Takashima, Kozo Kagawa, Toru Sawada, Hiroyuki Hino, Keishi Naruse, Eiji Takeuchi, Shoji Sakiyama, Tsutomu Shinohara
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-5 (2022)
Abstract Background The prognosis of thymoma with cardiac tamponade is generally poor. Most of the reported thymomas with cardiac tamponade were type B or type AB (mixed thymoma), and cardiac tamponade due to type A thymoma, which has a better progno
Externí odkaz:
https://doaj.org/article/6dc651c89abf4f18bc21518867d1e744