Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Tsutomu Sakuma"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 4, Pp 420-425 (2004)
Uridine 5′-triphosphate (UTP) increases chloride secretion followed by fluid movement into the proximal airspaces. However, little is known about whether UTP affects fluid movement in the distal airspaces. We studied the effect of UTP on basal and
Externí odkaz:
https://doaj.org/article/c23c69c0aeb840c7a8e11f8d80e9105b
Publikováno v:
Drug Metabolism and Pharmacokinetics. 48:100485
Autor:
Nobuhisa Yajima, Yusuke Gokon, Kazutomi Takahashi, Takashi Sawai, Motohisa Hagiwara, Fumiyoshi Fujishima, Yusuke Taniyama, Masashi Zuguchi, Tsutomu Sakuma, Takashi Kamei, Akiko Nishida, Rikiya Kanba, Hironobu Sasano, Yuko Itakura, Miwa Uzuki, Hirofumi Ichikawa, Yohei Ozawa, Taku Yamagata, Masahiro Saito, Hirotaka Ishida, Kazuhiro Sakamoto
Publikováno v:
Virchows Archiv. 477:825-834
The immune microenvironment plays a pivotal role in cancer development and progression. Therefore, we studied the status of immune cells in esophageal adenocarcinoma (EAC) and adjacent Barrett's esophagus (BE) and their association with the clinical
Publikováno v:
J Biol Chem
Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor (CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to xenobiotics and activate cytochrome P450 (CYP) genes. An anti-epileptic dr
Autor:
Yohei Ozawa, Fumiyoshi Fujishima, Yusuke Taniyama, Masashi Zuguchi, Hironobu Sasano, Akiko Nishida, Yusuke Gokon, Hirotaka Ishida, Nobuhisa Yajima, Kazutomi Takahashi, Motohisa Hagiwara, Tsutomu Sakuma, Taku Yamagata, Kazuhiro Sakamoto, Yuko Itakura, Takashi Kamei, Hirofumi Ichikawa, Takashi Sawai, Masahiro Saito, Miwa Uzuki
Publikováno v:
Pathology internationalREFERENCES. 70(6)
Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation-associated cancer. Glucocorticoids suppress inflammation through glucocortico
Autor:
Muluneh Fashe, Sawako Shindo, Tomohiko Kanayama, Masahiko Negishi, Tatsuya Sueyoshi, Tsutomu Sakuma, Rick Moore, Manas K. Ray
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 99(10)
Retinoid X receptor α (RXRα) has a conserved phosphorylation motif at threonine 162 (humans) and threonine 167 (mice) within the DNA-binding domain. Here we have generated RXRα knock-in mice (RxrαT167A) bearing a single mutation of Thr 167 to ala
Autor:
Naoto Kimura, Ryosuke Doijiri, Hiroshi Yaegashi, Asami Kamada, Daiji Obara, Takahiko Kikuchi, Michiko Yokosawa, Tsutomu Sakuma, Hiroaki Takahashi, Takayuki Sugawara, Eriko Yamaguchi, Ken Takahashi
Publikováno v:
Stroke. 49
Introduction: Histopathological analysis of the thrombi, which was retrieved from stroke patients with large-vessel occlusion during mechanical thrombectomy, may provide information about underlying pathologies. It is likely that the size of the thro
Autor:
Katsuo Usuda, Munetaka Matoba, Sumiko Maeda, Tsutomu Sakuma, Motoyasu Sagawa, Yuichiro Machida, Nozomu Motomo, Yoshimichi Ueda, Makoto Tanaka, Masakatsu Ueno, Hisao Tonami
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 15:6843-6848
Background: Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or meta
Autor:
Motoyasu Sagawa, Munetaka Matoba, Yuichiro Machida, Sumiko Maeda, Makoto Tanaka, Katsuo Usuda, Yasuaki Kuginuki, Mitsuru Taniguchi, Tsutomu Sakuma, Yoshimichi Ueda, Nozomu Motono, Masakatsu Ueno, Hisao Tonami
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 15:4629-4635
Background Diffusion-weighted imaging (DWI) makes it possible to detect malignant tumors based on the diffusion of water molecules. However, it is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary no
Autor:
Masakatsu Ueno, Hisao Tonami, Nozomu Motono, Motoyasu Sagawa, Munetaka Matoba, Mitsuru Taniguchi, Tsutomu Sakuma, Yuichiro Machida, Makoto Tanaka, Yoshimichi Ueda, Katsuo Usuda
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 15:657-662
Background: The epidermal growth factor receptor (EGFR) mutation status of lung cancer is important because it means that EGFR-tyrosine kinase inhibitor treatment is indicated. The purpose of this prospective study is to determine whether EGFR mutati