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pro vyhledávání: '"Tsutomu Kurokawa"'
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Autor:
Yasuhiro Tomaru, Ryo Ukekawa, Harukazu Suzuki, Yoshinari Ando, Yoshihide Hayashizaki, Tsutomu Kurokawa, A. Maxwell Burroughs, Michiel J. L. de Hoon, Taku Funakoshi, Carsten O. Daub, Takahiro Nishibu
Publikováno v:
Genome Research. 20:1398-1410
The genomes of most animal species encode for mature microRNA (miRNA) (Grimson et al. 2008), a distinct class of 20–24-nucleotide (nt) base pair single-stranded noncoding RNA (ncRNA) which post-transcriptionally regulates messenger RNA (mRNA) copy
Autor:
Mari Asada, Shoji Fukusumi, Chieko Kitada, Yuji Kawamata, Yoshio Matsumoto, Takanori Yamamoto, Masaki Tanaka, Yasuko Terao, Tsutomu Kurokawa, Takahiko Yano, Takuya Watanabe, Kuniko Kikuchi, Masahiko Fujino, Osamu Nishimura, Yasushi Shintani, Haruo Onda, Yasuhiko Ibata, Shuji Hinuma, Ryo Fujii, Norio Iijima, Masaki Hosoya, Yugo Habata
Publikováno v:
Nature Cell Biology. 2:703-708
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfect
Autor:
Yuji Kawamata, Susumu Honda, Tsutomu Kurokawa, Osamu Nishimura, Yugo Habata, Shuji Hinuma, Haruo Onda, Masaki Hosoya, Chieko Kitada, Masahiko Fujino, Ryo Fujii, Shoji Fukusumi
Publikováno v:
Journal of Biological Chemistry. 275:21061-21067
We have recently identified apelin as the endogenous ligand for human APJ. In rats, the highest expression of APJ mRNA was detected in the lung, suggesting that APJ and its ligand play an important role in the pulmonary system. When apelin-36 and its
Autor:
Yoshihiro Ishibashi, Chieko Kitada, Mioko Harada, Tsutomu Kurokawa, Hideki Matsui, Tetsuya Ohtaki, Masahiko Fujino, Satoshi Kumano, Kazuhiro Ogi, Haruo Onda
Publikováno v:
Journal of Biological Chemistry. 274:37041-37045
Galanin is a widely distributed neuropeptide with a variety of physiological functions. Three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been reported. We isolated a novel galanin-like peptide (GALP) from porcine hypothalamus by observi
Autor:
Masahiko Fujino, Yugo Habata, Shuji Hinuma, Yuji Kawamata, Haruo Onda, Naoki Nishizawa, Ryo Fujii, Chieko Kitada, Tsutomu Kurokawa, Shoji Fukusumi, Masaki Hosoya, Shinji Murosaki, Kazuhiko Tatemoto
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1452:25-35
By using a strategy that we have developed to search for the ligands of orphan seven-transmembrane-domain receptors [S. Hinuma et al., Nature 393 (1998) 272–276], we have recently identified a natural ligand, apelin, for the orphan 7TMR, APJ [K. Ta
Autor:
Masaaki Mori, Yukio Shimomura, Tsutomu Kurokawa, Yasuhiro Sumino, Yoshihiro Ishibashi, Haruo Onda, Michiko Abe, Masahiko Fujino, Tsukasa Sugo, Osamu Nishimura
Publikováno v:
Biochemical and Biophysical Research Communications. 261:622-626
Melanin-concentrating hormone (MCH), which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor. We established a CHO cell line expressing the rat SLC-1 receptor to search for its endogenous ligand. The
Autor:
Takashi Kanda, Hidehiro Mizusawa, Satoshi Nakamura, Kazuhiko Ikeda, Akira Ueki, Takayuki Iwasaki, Tsutomu Kurokawa
Publikováno v:
International Journal of Developmental Neuroscience. 17:191-200
Motoneurons need muscle-derived neurotrophic substances for their survival during the initial phase of their development, but after maturation they lose this requirement and can survive after axotomy. This suggests that some neurotrophic substances o
Autor:
Tadao Kakegawa, Masaki Hosoya, Shuji Hinuma, Kazuhiko Tatemoto, Tsutomu Kurokawa, Yugo Habata, Min-Xu Zou, Shoji Fukusumi, Haruo Onda, Ryo Fujii, Yuji Kawamata, Chieko Kitada, Masahiko Fujino
Publikováno v:
Biochemical and Biophysical Research Communications. 251:471-476
In the search for an endogenous ligand of the orphan G protein-coupled receptor APJ, the presence of the ligand in various tissue extracts was examined by measuring the increase in extracellular acidification rate of the cells expressing the APJ rece
Autor:
Chisako Nomura, Junko Habashita, Tsutomu Kurokawa, Ken-Ichi Kuroshima, Sumie Matsumoto-Yoshitomi
Publikováno v:
International Journal of Cancer. 71:442-450
Transfection of human fibroblast growth factor 9 (FGF-9) cDNA into mouse BALB/c 3T3 clone A31 cells led to morphological transformation of the cells and foci formation 4 weeks later. Isolated transformants had a higher saturation density than parenta