Zobrazeno 1 - 10
of 591
pro vyhledávání: '"Tsutomu Imaizumi"'
Autor:
Tsutomu Imaizumi, Ryuhei Hayashi, Yuji Kudo, Xiaoqin Li, Kaito Yamaguchi, Shun Shibata, Toru Okubo, Tsuyoshi Ishii, Yoichi Honma, Kohji Nishida
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Dry eye syndrome (DES) is a chronic ocular disease that induces epithelial damage to the cornea by decreasing tear production and quality. Adequate treatment options have not been established for severe DES such as Sjogren’s syndrome due t
Externí odkaz:
https://doaj.org/article/8c8b39604a854bff9cdcdd92184c8e66
Autor:
Eiko Sakai, Tsutomu Imaizumi, Ruruka Suzuki, Marcos Taracena-Gándara, Toshiki Fujimoto, Fuminori Sakurai, Hiroyuki Mizuguchi
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Non-alcoholic liver disease (NAFLD) is a condition caused by excessive fat accumulation in the liver and developed via multiple pathways. miR-27b has been suggested to play crucial roles in the development of NAFLD, assuming via targeting ge
Externí odkaz:
https://doaj.org/article/fa4aa7184a1e4c88a2269c26b8eaf74c
Autor:
Saki Hirakata, MD, Hiroki Aoki, MD, PhD, Satoko Ohno-Urabe, MD, PhD, Michihide Nishihara, MD, PhD, Aya Furusho, MD, PhD, Norifumi Nishida, MD, Sohei Ito, MD, Makiko Hayashi, MD, Hideo Yasukawa, MD, PhD, Tsutomu Imaizumi, MD, PhD, Sinichi Hiromatsu, MD, PhD, Hiroyuki Tanaka, MD, PhD, Yoshihiro Fukumoto, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 126-144 (2020)
Summary: Aortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of
Externí odkaz:
https://doaj.org/article/83a8bf407ee34e8189a3a5b7ac49083d
Autor:
Fuminori Sakurai, Rina Hashimoto, Chieko Inoue, Keisaku Wakabayashi, Tomohito Tsukamoto, Tsutomu Imaizumi, Taracena Gandara Marcos Andres, Eiko Sakai, Kanae Itsuki, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi
Publikováno v:
Virology Journal, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background MicroRNAs (miRNAs) have gained much attention as cellular factors regulating hepatitis C virus (HCV) infection. miR-27b has been shown to regulate HCV infection in the hepatocytes via various mechanisms that have not been fully el
Externí odkaz:
https://doaj.org/article/b2e8a13d51934e9fbbf17deb4b439c14
Autor:
Chisato Watanabe, Tsutomu Imaizumi, Hiromi Kawai, Kazuma Suda, Yoichi Honma, Masamitsu Ichihashi, Masatsugu Ema, Ken-ichi Mizutani
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Vertebrates have acquired complex high-order functions facilitated by the dispersion of vascular and neural networks to every corner of the body. Blood vessels deliver oxygen and nutrients to all cells and provide essential transport systems for remo
Externí odkaz:
https://doaj.org/article/f8a33dc00194489bb908e333567cf146
Autor:
Hiroki Uchiwa, Hisashi Kai, Yoshiko Iwamoto, Takahiro Anegawa, Hidemi Kajimoto, Kenji Fukuda, Tsutomu Imaizumi, Yoshihiro Fukumoto, for the MAPPY Study Investigators
Publikováno v:
Clinical and Experimental Hypertension, Vol 40, Iss 3, Pp 267-273 (2018)
Morning hypertension is an independent risk for cerebrovascular and cardiovascular events. Although the prevalence of morning hypertension increases with age, treatment of morning hypertension has not been established, particularly in Very-Elderly pa
Externí odkaz:
https://doaj.org/article/e96921c8f04a44b5bf9509b4f3b83ec9
Autor:
Aya Furusho, Hiroki Aoki, Satoko Ohno‐Urabe, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Tsutomu Imaizumi, Shinichi Hiromatsu, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)
BackgroundAbdominal aortic aneurysm (AAA) is a potentially life‐threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enrich
Externí odkaz:
https://doaj.org/article/9492db002dcb45b3a1cfd72148deaa27
Autor:
Satoko Ohno‐Urabe, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hideo Yasukawa, Tsutomu Imaizumi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 2 (2018)
BackgroundAortic dissection (AD) is a life‐threatening medical emergency caused by the abrupt destruction of the intimomedial layer of the aortic walls. Given that previous studies have reported the involvement of proinflammatory cytokine interleuk
Externí odkaz:
https://doaj.org/article/cd499ab5c5b544cfb1f158a739decd87
Autor:
Michihide Nishihara, Hiroki Aoki, Satoko Ohno, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Tsutomu Imaizumi, Yoshihiro Fukumoto
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185923 (2017)
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear, evidence is accumulating to support a central role for inflammation. Inflammatory responses are coordinated by various soluble cytokines of which IL-6 is one of the major p
Externí odkaz:
https://doaj.org/article/12462ace24eb4b049d9036d97bc276c0
Autor:
Takanobu Nagata, Hideo Yasukawa, Sachiko Kyogoku, Toyoharu Oba, Jinya Takahashi, Shoichiro Nohara, Tomoko Minami, Kazutoshi Mawatari, Yusuke Sugi, Koutatsu Shimozono, Sylvain Pradervand, Masahiko Hoshijima, Hiroki Aoki, Yoshihiro Fukumoto, Tsutomu Imaizumi
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127942 (2015)
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT) 3 is potently cardioprotect
Externí odkaz:
https://doaj.org/article/8d05709fc4874091845e44d11e40e62e