Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Tsutomu Higashijima"'
Autor:
Tsutomu Higashijima, Masanao Ohya, Shun'ichi Kinoshita, Toshiyuki Kohno, Kaori Wakamatsu, Takeshi Tanaka, Hidehito Mukai, Tatsuo Miyazawa, Hiroshi Itoh
Publikováno v:
Journal of Biological Chemistry. 273:3247-3252
To elucidate the mechanism whereby liganded receptor molecules enhance nucleotide exchange of GTP-binding regulatory proteins (G proteins), changes in the secondary structure of the recombinant Gi1 alpha subunit (Gi1alpha) upon binding with receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd77aa385ae3379acff9b2347652da88
https://doi.org/10.1074/jbc.273.6.3247
https://doi.org/10.1074/jbc.273.6.3247
Publikováno v:
Biochemistry. 33:9438-9446
We determined a detailed conformation of the honeybee venom peptide melittin when bound to phosphatidylcholine vesicles using proton NMR. In the presence of vesicles of perdeuterated dipalmitoylglycerophosphocholine, two-dimensional transferred nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6da97d857a598e7f0153c625a6b1c0
https://doi.org/10.1021/bi00198a009
https://doi.org/10.1021/bi00198a009
Publikováno v:
The Journal of Biochemistry. 115:463-468
We previously showed that peptides corresponding to the N-terminal parts of the third intracellular loops of turkey and hamster beta-adrenergic receptors (tu beta I3N and ha beta I3N, respectively) can activate the GS protein (one of the GTP-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e36275b675e1b648b8d4f75ef0994c9
https://doi.org/10.1093/oxfordjournals.jbchem.a124360
https://doi.org/10.1093/oxfordjournals.jbchem.a124360
Autor:
M Sukumar, Tsutomu Higashijima
Publikováno v:
Journal of Biological Chemistry. 267:21421-21424
Mastoparans are a family of 14-residue peptide toxins from wasp venom which have been proposed to stimulate secretion from a variety of cells, by directly activating GTP-binding regulatory proteins (G proteins). In vitro studies have shown that masto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb9c36c1eb2e6c63befa6db225f98ed
https://doi.org/10.1016/s0021-9258(19)36626-8
https://doi.org/10.1016/s0021-9258(19)36626-8
Publikováno v:
Journal of Biological Chemistry. 267:16237-16243
A substance P (SP) analog, [D-Pro4,D-Trp7,9,10] SP4-11, is known to inhibit the actions of various structurally unrelated messenger molecules as well as SP. Our studies on the effects of this peptide on the regulation of purified G proteins by recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0c492b31e2820738c16f5a96c83c1e
https://doi.org/10.1016/s0021-9258(18)41991-6
https://doi.org/10.1016/s0021-9258(18)41991-6
Publikováno v:
Biochemistry. 31:5654-5660
Mastoparan-X, a tetradecapeptide from wasp venom, has been proposed to cause secretion from various kinds of cells by the direct activation of GTP-binding regulatory proteins (G proteins) that couple to phospholipase C. The mechanism of the activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319c06cb7e8c9502447562b7c0319550
https://doi.org/10.1021/bi00139a032
https://doi.org/10.1021/bi00139a032
Autor:
Gabriel Berstein, Jonathan L. Blank, Tsutomu Higashijima, Alan V. Smrcka, Paul C. Sternweis, Elliott M. Ross, John H. Exton
Publikováno v:
Journal of Biological Chemistry. 267:8081-8088
We describe the reconstitution using purified proteins of the m1 muscarinic cholinergic pathway that activates phosphatidylinositol 4,5-bisphosphate-specific phospholipase C via the G protein Gq/11. Recombinant m1 muscarinic receptor was co-reconstit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d358ae2b064eef4e2dd4ea0c439b07
https://doi.org/10.1016/s0021-9258(18)42410-6
https://doi.org/10.1016/s0021-9258(18)42410-6
Autor:
Tsutomu Higashijima
Publikováno v:
Folia Pharmacologica Japonica. 99:267-274
G proteins act as signal transducers that couple receptors to effectors through membranes. G proteins are in a GDP-bound form in the basal state, which can interact with receptors. The hormone-bound receptor promotes GDP-GTP exchange of G proteins. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c6d67e9791ed86f04c7f49a126520a
https://doi.org/10.1254/fpj.99.267
https://doi.org/10.1254/fpj.99.267
Autor:
Elliott M. Ross, Tsutomu Higashijima
Publikováno v:
Journal of Biological Chemistry. 266:12655-12661
Mastoparan (MP) activates GTP-binding regulatory proteins (G proteins) by promoting GDP/GTP exchange through a mechanism similar to that of G protein-coupled receptors (Higashijima, T., Burnier, J., and Ross, E. M. (1990) J. Biol. Chem. 265, 14176-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd55088530f720accbda3a0b78564b35
https://doi.org/10.1016/s0021-9258(18)98949-0
https://doi.org/10.1016/s0021-9258(18)98949-0
Publikováno v:
Journal of Biological Chemistry. 266:3396-3401
19F and 31P NMR spectroscopy was used to study the mechanism of activation of the alpha subunits of guanine nucleotide-binding regulatory proteins (G proteins) by Al3+, Mg2+, and F-. 19F NMR spectra of solutions containing Al3+, Mg2+, and F- showed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9869683f61895b30656de68bac490897
https://doi.org/10.1016/s0021-9258(19)67806-3
https://doi.org/10.1016/s0021-9258(19)67806-3