Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tsutomu Akama"'
Autor:
Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1151 (2011)
BACKGROUND: Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists for the discovery and development of new, safe, and effective drugs to
Externí odkaz:
https://doaj.org/article/63cd3700496b42e79618890a16e02bc3
Autor:
Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock
Publikováno v:
ACS Infectious Diseases
The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness,
Autor:
Angel M. Padilla, Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs, Rick L. Tarleton
Publikováno v:
Nature microbiology. 7(10)
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here w
Autor:
Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs
Publikováno v:
ACS Infectious Diseases
A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river b
Autor:
Yasheen Zhou, Defauw Jean Marie, Terry William Balko, Eric E. Easom, Wuxin Zou, Jianxin Cao, Tsutomu Akama, Yong-Kang Zhang, Joseph Raymond Winkle, Jian Xue, Wei Bu, Jacob J. Plattner, Shenghai Guo, W. Hunter White
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5589-5593
A novel series of isoxazoline benzoxaborole small molecules was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the ectoparasiticide activity against ticks and fleas. The study identified an orally bioavai
Autor:
Tsutomu, Akama, Yong-Kang, Zhang, Yvonne R, Freund, Pamela, Berry, Joanne, Lee, Eric E, Easom, Robert T, Jacobs, Jacob J, Plattner, Michael J, Witty, Rosemary, Peter, Tim G, Rowan, Kirsten, Gillingwater, Reto, Brun, Bakela, Nare, Luke, Mercer, Musheng, Xu, Jiangong, Wang, Hao, Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolen
Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolen
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3f0e4bfaa15c187af099b0b29e19c4a
https://doi.org/10.29200/acsmedchemrev-v51.ch20
https://doi.org/10.29200/acsmedchemrev-v51.ch20
Autor:
Liang Liu, Yasheen Zhou, Kurt Jarnagin, Charlotte Virtucio, Xiaoqing Fan, Yong-Kang Zhang, Fernando Rock, Wei Bu, Tsutomu Akama, David C. Sullivan, Yvonne Freund, Chen Dong, Anne Wu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:615-625
Benzoxaboroles are a novel class of drug-like compounds that have been rich sources of novel inhibitors for various enzymes and of new drugs. While examining benzoxaborole activity in phenotypic screens, our attention was attracted by the (aminomethy
Inhibition of Toll-Like Receptor-Mediated Inflammation In Vitro and In Vivo by a Novel Benzoxaborole
Autor:
Charlotte Virtucio, Kurt Jarnagin, Yvonne Freund, Chen Dong, Xiaoqin Fan, Wei Bu, Ana Gertrudes, Lisa Feng, Liang Liu, Tsutomu Akama, Holly Sexton, Shamra Martin, Chiao-Wen Chen, Anne Wu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:436-446
Pro-inflammatory cytokines play a critical role in the development of autoimmune and inflammatory diseases. Targeting the cytokine environment has proven efficient for averting inflammation. In this study, we reported that 6-[4-(aminomethyl)-2-chloro
Autor:
Jianzhang Yang, Joseph Raymond Winkle, Jacob J. Plattner, Yong-Kang Zhang, Zhixin Ge, Eric E. Easom, Jianxin Cao, Terry William Balko, Yasheen Zhou, Defauw Jean Marie, W. Hunter White, Tsutomu Akama
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
Novel isoxazoline amide benzoxaboroles were designed and synthesized to optimize the ectoparasiticide activity of this chemistry series against ticks and fleas. The study identified an orally bioavailable molecule, (S)-N-((1-hydroxy-3,3-dimethyl-1,3-