Zobrazeno 1 - 10
of 1 398
pro vyhledávání: '"Tsutomu, Takeuchi"'
Autor:
Peter C. Taylor, Bryan Downie, Ling Han, Rachael Hawtin, Angie Hertz, Robert J. Moots, Tsutomu Takeuchi
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 5, Pp 1383-1392 (2024)
Abstract Introduction High baseline neutrophil-to-lymphocyte ratio (NLR) in rheumatoid arthritis (RA) has been associated with positive responses to biologic tumor necrosis factor inhibition and negative responses to conventional synthetic disease-mo
Externí odkaz:
https://doaj.org/article/8791698927c94580b5379123fd399380
Autor:
Nam Cong-Nhat Huynh, Rui Ling, Masatsugu Komagamine, Tianshu Shi, Masayuki Tsukasaki, Kotaro Matsuda, Kazuo Okamoto, Tatsuo Asano, Ryunosuke Muro, Warunee Pluemsakunthai, George Kollias, Yuko Kaneko, Tsutomu Takeuchi, Sakae Tanaka, Noriko Komatsu, Hiroshi Takayanagi
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-18 (2024)
Abstract Background Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK inhibitors which ameli
Externí odkaz:
https://doaj.org/article/ea3736b484c44dd68e91bd945e1b9dbe
Autor:
Ronald van Vollenhoven, Vibeke Strand, Tsutomu Takeuchi, Nilmo Chávez, Pablo Mannucci Walter, Atul Singhal, Jerzy Swierkot, Nasser Khan, Xianwei Bu, Yihan Li, Sara K. Penn, Heidi S. Camp, Jacob Aelion
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background To evaluate the efficacy and safety of upadacitinib monotherapy versus methotrexate (MTX) monotherapy over 5 years among MTX-naïve patients with moderately to severely active rheumatoid arthritis (RA) in the long-term extension (
Externí odkaz:
https://doaj.org/article/d96238b03a104e99a640cf8bd22d5e92
Autor:
Jun Inamo, Akari Suzuki, Mahoko Takahashi Ueda, Kensuke Yamaguchi, Hiroshi Nishida, Katsuya Suzuki, Yuko Kaneko, Tsutomu Takeuchi, Hiroaki Hatano, Kazuyoshi Ishigaki, Yasushi Ishihama, Kazuhiko Yamamoto, Yuta Kochi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Alternative splicing events are a major causal mechanism for complex traits, but they have been understudied due to the limitation of short-read sequencing. Here, we generate a full-length isoform annotation of human immune cells from an ind
Externí odkaz:
https://doaj.org/article/101fdd61e5eb484db7b4fe4e81d319d3
Autor:
Tsutomu Takeuchi, Yoshiya Tanaka, Rangi Kandane-Rathnayake, Ning Li, Sang-Cheol Bae, Zhanguo Li, Shereen Oon, Vera Golder, Mandana Nikpour, Masayoshi Harigai, Yi-Hsing Chen, Zhuoli Zhang, Eric Morand, Chak Sing Lau, Worawit Louthrenoo, Alberta Hoi, Sandra Navarra, Sean O’Neill, Shue-Fen Luo, Jun Kikuchi, Yanjie Hao, Yasuhiro Katsumata, Aisha Lateef, Laniyati Hamijoyo, Sargunan Sockalingam, Nicola Tugnet, Madelynn Chan, Jiacai Cho, Leonid Zamora, Fiona Goldblatt, Kristine Ng, Yeong-Jian Jan Wu, Dylan Hansen, B M D B Basnayake
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 2 (2024)
Objectives The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This study aimed to evaluate the outcomes of patients who a
Externí odkaz:
https://doaj.org/article/cb33790523424640ae42812b39be75b7
Publikováno v:
RMD Open, Vol 10, Iss 3 (2024)
Objectives This study aimed to evaluate the long-term safety and efficacy profiles of ozoralizumab in patients with rheumatoid arthritis (RA) from the OHZORA, NATSUZORA and HOSHIZORA trials.Methods This study conducted an integrated analysis of the t
Externí odkaz:
https://doaj.org/article/fcfd4e7e78c342cca973a8b09b70b145
Autor:
Keisuke Izumi, Kanata Suzuki, Masahiro Hashimoto, Masahiro Jinzaki, Shigeru Ko, Tsutomu Takeuchi, Yuko Kaneko
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The modified total Sharp score (mTSS) is often used as an evaluation index for joint destruction caused by rheumatoid arthritis. In this study, special findings (ankylosis, subluxation, and dislocation) are detected to estimate the efficacy
Externí odkaz:
https://doaj.org/article/95ad1bd09d9c4f47b746ca856badd7d4
Autor:
Noriyasu Seki, Hideto Tsujimoto, Shuhei Tanemura, Shinji Kojima, Fumihiko Miyoshi, Jun Kikuchi, Shuntaro Saito, Mitsuhiro Akiyama, Kunio Sugahara, Keiko Yoshimoto, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic role in autoimmune diseases. However, the role of Tph subsets is not fully elucidated. Here, we investigate the immunologic
Externí odkaz:
https://doaj.org/article/8ddd1a39fa6f4692bca56b92a70671ef
Autor:
Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Hirofumi Kamata, Makoto Ishii, Yoshitaka Oyamada, Hisaji Oshima, Satoshi Usuda, Kazuyuki Tsunoda, Tsutomu Takeuchi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Interstitial lung disease is a common complication of anti-synthetase syndrome (ASS), and lymphocytic infiltration is often observed in the lesion. We have recently reported that disease-specific autoantibodies are produced by infiltrating lymphocyte
Externí odkaz:
https://doaj.org/article/d7f67e22fa9f430da443f477468e3e06
Autor:
Andrea Rubbert-Roth, Adriana M. Kakehasi, Tsutomu Takeuchi, Marc Schmalzing, Hannah Palac, Derek Coombs, Jianzhong Liu, Samuel I. Anyanwu, Ralph Lippe, Jeffrey R. Curtis
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 1, Pp 97-112 (2023)
Abstract Introduction This article aims to describe malignancies in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), or non-radiographic axial spondyloarthritis (nr-axSpA) treated with upadacitinib (UPA
Externí odkaz:
https://doaj.org/article/a4e890c38a81458f8f0e15e86b14da3d