Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tsutomu, Suenaga"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:27-33
Two novel 20-hydroxyvitamin D3 analogues (4a,b) with the A-ring modification have been synthesized by a convergent manner. An alternative pathway of vitamin D3 metabolism by cytochrome P450scc CYP11A1 was reported to afford 20-hydroxyvitamin D3 (3),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f05bbf629cf2bafcf3e91891bfce0a
https://doi.org/10.1016/j.jsbmb.2018.10.019
https://doi.org/10.1016/j.jsbmb.2018.10.019
Autor:
Masayuki Morikawa, Toshie Fujishima, Hiroaki Isono, Tsutomu Suenaga, Keisuke Takaguchi, Yuri Takao, Takuro Komatsu, Wataru Yonamine
Publikováno v:
Tetrahedron. 75:1098-1106
Five novel vitamin D analogues ( 2a , 2b , 3a , 3b and 4 ) bearing an aromatic side chain have been designed and synthesized in a convergent manner. The requisite CD-ring synthons ( 10a–c ) were prepared from C22 aldehyde ( 5 ) using four- or five-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90cfca212710eba6e3d64ae81a2a1078
https://doi.org/10.1016/j.tet.2019.01.019
https://doi.org/10.1016/j.tet.2019.01.019
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 187
Two novel 20-hydroxyvitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6a50270dbe6cbd8e2a6b69832b47220
https://pubmed.ncbi.nlm.nih.gov/30389627
https://pubmed.ncbi.nlm.nih.gov/30389627
Publikováno v:
Current Topics in Medicinal Chemistry. 14:2446-2453
The hormonally active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1a), has a wide variety of biological activities and its major molecular target is considered to be the vitamin D receptor (VDR). The A-ring stereoisomers of 1a as well as its C2-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dfb1a76ecf98e1056d905c91ce57335
https://doi.org/10.2174/1568026615666141208102907
https://doi.org/10.2174/1568026615666141208102907
Publikováno v:
Tetrahedron Letters. 55:3805-3808
Two novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 bearing a spiro-oxetane at the C3 position of the A-ring have been designed and synthesized in a convergent manner. The absolute configuration at the C1 position of the synthesized compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb96daf0f9f85c91dd77423d8873a708
https://doi.org/10.1016/j.tetlet.2014.05.060
https://doi.org/10.1016/j.tetlet.2014.05.060
Publikováno v:
ChemInform. 45
Two novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 bearing a spiro-oxetane at the C3 position of the A-ring have been designed and synthesized in a convergent manner. The absolute configuration at the C1 position of the synthesized compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97870f575f22e076cf1d3fa75bcb9a6f
https://doi.org/10.1002/chin.201449199
https://doi.org/10.1002/chin.201449199
Publikováno v:
Current topics in medicinal chemistry. 14(21)
The hormonally active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1a), has a wide variety of biological activities and its major molecular target is considered to be the vitamin D receptor (VDR). The A-ring stereoisomers of 1a as well as its C2-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1b8d0653af3dc94a1299da0cf959a6f
https://pubmed.ncbi.nlm.nih.gov/25486939
https://pubmed.ncbi.nlm.nih.gov/25486939
Autor:
Guo-Dong Zhao, Chao Liu, Toshie Fujishima, Cheng-Mei Zhang, Xinliang Mao, Tsutomu Suenaga, Zhao-Peng Liu
Publikováno v:
European journal of medicinal chemistry. 85
Two new analogues of the steroid hormone 1α,25-dihydroxyvitamin D3 with aromatic side chains attached at C-17 were designed to investigate their effects on VDR, HL-60 cell differentiation and tumor cell proliferation. These analogues were prepared b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc98be5cce538dd963ac99054fa311e
https://pubmed.ncbi.nlm.nih.gov/25127149
https://pubmed.ncbi.nlm.nih.gov/25127149
Publikováno v:
Bioorganicmedicinal chemistry. 21(17)
Four structurally novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 (3a-d) bearing a spiro-oxetane fused at the C2 position of the A-ring have been designed and synthesised in a convergent manner. The requisite A-ring enyne precursors (13a,b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08e4f30f8990fb4cef3ec10243af30a
https://pubmed.ncbi.nlm.nih.gov/23845283
https://pubmed.ncbi.nlm.nih.gov/23845283