Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Tsutomu, Sasaki"'
Autor:
Tsutomu Sasaki, Sunao Hisada, Hideaki Kanki, Kazuto Nunomura, Bangzhong Lin, Kumiko Nishiyama, Tomohito Kawano, Shigenobu Matsumura, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Calcium oscillations in primary neuronal cultures and iPSCs have been employed to investigate arrhythmogenicity and epileptogenicity in drug development. Previous studies have demonstrated that Ca2+ influx via NMDA and nicotinic acetylcholin
Externí odkaz:
https://doaj.org/article/9b6e3447e8e248359c5367162194bbbc
Autor:
Takuya Moriyama, Kenichi Todo, Hiroshi Yamagami, Yoko Kimura, Shiro Yamamoto, Keiko Nagano, Ryosuke Doijiri, Hidekazu Yamazaki, Kazutaka Sonoda, Junpei Koge, Taira Nakayama, Tomonori Iwata, Yuji Ueno, Yasufumi Gon, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
High B-type natriuretic peptide (BNP) levels are associated with new atrial fibrillation (AF). This study investigated the distribution of AF detection rates according to BNP levels in patients with cryptogenic stroke (CS) using an insertable cardiac
Externí odkaz:
https://doaj.org/article/b51658c5b9d64febb87bcfc56cf42969
Autor:
Kazuhiro Nomura, Shinichi Kinoshita, Nao Mizusaki, Yoko Senga, Tsutomu Sasaki, Tadahiro Kitamura, Hiroshi Sakaue, Aki Emi, Tetsuya Hosooka, Masahiro Matsuo, Hitoshi Okamura, Taku Amo, Alexander M. Wolf, Naomi Kamimura, Shigeo Ohta, Tomoo Itoh, Yoshitake Hayashi, Hiroshi Kiyonari, Anna Krook, Juleen R. Zierath, Masato Kasuga, Wataru Ogawa
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101968- (2024)
The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists as multiple isofo
Externí odkaz:
https://doaj.org/article/17003285f15f45a0a37f5fca4575d05c
Autor:
Kenichi Todo, Shuhei Okazaki, Ryosuke Doijiri, Hidekazu Yamazaki, Kazutaka Sonoda, Junpei Koge, Tomonori Iwata, Yuji Ueno, Hiroshi Yamagami, Naoto Kimura, Masafumi Morimoto, Daisuke Kondo, Masatoshi Koga, Eiichiro Nagata, Nobukazu Miyamoto, Yoko Kimura, Yasufumi Gon, Tsutomu Sasaki, Hideki Mochizuki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Atrial fibrillation (AF) is known to be a strong risk factor for stroke. However, the risk of stroke recurrence in patients with cryptogenic stroke with AF detected after stroke by an insertable cardiac monitor (ICM) is not well known. We
Externí odkaz:
https://doaj.org/article/370a3d5d87df4f1b81a6dc389cad9877
Autor:
Tomohiro Kawano, Yasufumi Gon, Manabu Sakaguchi, Hiroshi Yamagami, Soichiro Abe, Hiroyuki Hashimoto, Nobuyuki Ohara, Daisuke Takahashi, Yuko Abe, Tsutomu Takahashi, Shuhei Okazaki, Kenichi Todo, Hideki Mochizuki, Tsutomu Sasaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) antigen leve
Externí odkaz:
https://doaj.org/article/cb66abdc8ef146998afb92e7b89ba509
Autor:
Yasufumi Gon, Ling Zha, Tsutomu Sasaki, Toshitaka Morishima, Yuko Ohno, Hideki Mochizuki, Tomotaka Sobue, Isao Miyashiro
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Background Data on the risk of cardiovascular‐related mortality in patients with cancer are limited. Methods and Results This retrospective cohort study used data from the Osaka Cancer Registry and vital statistics in Japan between 1985 and 2013. T
Externí odkaz:
https://doaj.org/article/625e6965ebae4abda0f5e5f9c13bbc11
Autor:
Shintaro Sugiyama, Tsutomu Sasaki, Hiroo Tanaka, Haomin Yan, Takeshi Ikegami, Hideaki Kanki, Kumiko Nishiyama, Goichi Beck, Yasufumi Gon, Shuhei Okazaki, Kenichi Todo, Atsushi Tamura, Sachiko Tsukita, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Blood–brain barrier (BBB) disruption contributes to brain injury and neurological impairment. Tight junctions (TJs) and cell–cell adhesion complexes develop between endothelial cells in the brain to establish and maintain the BBB. Occlud
Externí odkaz:
https://doaj.org/article/41678653a17c4fecad0c010b521563ea
Autor:
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, Akiko Nakata, Minoru Yoshida, Shinichi Uesato, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation. But Mdmx dynamics in ce
Externí odkaz:
https://doaj.org/article/d535ef55554745bdb1de765b94ef736c
Autor:
Yasufumi Gon, Manabu Sakaguchi, Hiroshi Yamagami, Soichiro Abe, Hiroyuki Hashimoto, Nobuyuki Ohara, Daisuke Takahashi, Yuko Abe, Tsutomu Takahashi, Takaya Kitano, Shuhei Okazaki, Kenichi Todo, Tsutomu Sasaki, Satoshi Hattori, Hideki Mochizuki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)
Background Limited data exist on the prognostic factors for patients with ischemic stroke and active cancer. Methods and Results We conducted a prospective, multicenter, observational study in Japan, including patients with acute ischemic stroke and
Externí odkaz:
https://doaj.org/article/92850991fe7f49ccbeee3f9aa0f602f2
Autor:
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)
Background Immune cells play a vital role in the pathology of ischemic stroke. Neutrophils and polymorphonuclear myeloid‐derived suppressor cells share a similar phenotype and have attracted increasing attention in immune regulation research, yet t
Externí odkaz:
https://doaj.org/article/a8a324306f5f4ac28e2ff7c41744bf5a