Genetic determinants of serum testosterone concentrations in men.

Autor: Claes Ohlsson, Henri Wallaschofski, Kathryn L Lunetta, Lisette Stolk, John R B Perry, Annemarie Koster, Ann-Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T Huhtaniemi, Geoffrey L Hammond, Marcello Maggio, Andrea D Coviello, EMAS Study Group, Luigi Ferrucci, Margit Heier, Albert Hofman, Kate L Holliday, John-Olov Jansson, Mika Kähönen, David Karasik, Magnus K Karlsson, Douglas P Kiel, Yongmei Liu, Osten Ljunggren, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Thomas Meitinger, Dan Mellström, David Melzer, Iva Miljkovic, Matthias Nauck, Maria Nilsson, Brenda Penninx, Stephen R Pye, Ramachandran S Vasan, Martin Reincke, Fernando Rivadeneira, Abdelouahid Tajar, Alexander Teumer, André G Uitterlinden, Jagadish Ulloor, Jorma Viikari, Uwe Völker, Henry Völzke, H Erich Wichmann, Tsung-Sheng Wu, Wei Vivian Zhuang, Elad Ziv, Frederick C W Wu, Olli Raitakari, Anna Eriksson, Martin Bidlingmaier, Tamara B Harris, Anna Murray, Frank H de Jong, Joanne M Murabito, Shalender Bhasin, Liesbeth Vandenput, Robin Haring

Publikováno v: PLoS Genetics, Vol 7, Iss 10, p e1002313 (2011)

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide

Externí odkaz: https://doaj.org/article/5e1b69b3dd67477b8f3c8991cffe202d

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia

Autor: Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo

Publikováno v: Journal of Medicinal Chemistry. 62:11135-11150

Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60499fc4136ddd2d5cf080a65b7dda3b
https://doi.org/10.1021/acs.jmedchem.9b01229

Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth

Autor: Fang-Jen S. Lee, Shin Jin Lin, Chun Fang Huang, Chun Chun Li, Tsung Sheng Wu

Publikováno v: Molecular Biology of the Cell

ADP-ribosylation factor (Arf)-like 4D (Arl4D), one of the Arf-like small GTPases, functions in the regulation of cell morphology, cell migration, and actin cytoskeleton remodeling. End-binding 1 (EB1) is a microtubule (MT) plus-end tracking protein t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830489a94f2b31df17e2b817e24e79d6
https://pubmed.ncbi.nlm.nih.gov/32755434

Naturally Occurring Mutants Inform SHBG Structure and Function

Autor: Geoffrey L. Hammond, Tsung-Sheng Wu

SHBG transports and regulates the activities of androgens and estrogens. Several single nucleotide polymorphisms in the human SHBG gene have been linked to sex steroid-dependent diseases, including those associated with the metabolic syndrome. The N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa4c41465b8e19698832503c126d4c2
https://europepmc.org/articles/PMC5414826/

Genetic determinants of serum testosterone concentrations in men

Autor: Uwe Völker, Brenda W.J.H. Penninx, André G. Uitterlinden, Douglas P. Kiel, Abdelouahid Tajar, John-Olov Jansson, Frederick C. W. Wu, Yongmei Liu, Tsung Sheng Wu, Andrea D. Coviello, Robin Haring, Stephen R Pye, Luigi Ferrucci, Kathryn L. Lunetta, Henry Völzke, John R. B. Perry, Iva Miljkovic, Tamara B. Harris, Ilpo Huhtaniemi, Mika Kähönen, Albert Hofman, Östen Ljunggren, Maria Nilsson, Ann-Kristin Petersen, Thomas Meitinger, Alexander Teumer, Ramachandran S. Vasan, Joel Eriksson, Magnus Karlsson, Geoffrey L. Hammond, Claes Ohlsson, Henri Wallaschofski, Lisette Stolk, Kate L. Holliday, Frank H. de Jong, Anna Eriksson, Elad Ziv, Olli T. Raitakari, Martin Bidlingmaier, Liesbeth Vandenput, Annemarie Koster, Margit Heier, Wei Vivian Zhuang, Martin Reincke, Marcello Maggio, Joanne M. Murabito, Matthias Nauck, Shalender Bhasin, Anna Murray, David Melzer, J. Viikari, Fernando Rivadeneira, Dan Mellström, David Karasik, Mattias Lorentzon, H.-Erich Wichmann, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Jagadish Ulloor

Publikováno v: PLoS Genet. 7:e1002313 (2011)
PLoS genetics, vol 7, iss 10
Ohlsson, C, Wallaschofski, H, Lunetta, K L, Stolk, L, Perry, J R B, Koster, A, Petersen, A K, Eriksson, J, Lehtimaki, T, Huhtaniemi, I T, Hammond, G L, Maggio, M, Coviello, A D, Ferrucci, L, Heier, M, Hofman, A, Holliday, K L, Jansson, J O, Kahonen, M, Karasik, D, Karlsson, M K, Kiel, D P, Liu, Y M, Ljunggren, O, Lorentzon, M, Lyytikainen, L P, Meitinger, T, Mellstrom, D, Melzer, D, Miljkovic, I, Nauck, M, Nilsson, M, Penninx, B W J H, Pye, S R, Vasan, R S, Reincke, M, Rivadeneira, F, Tajar, A, Teumer, A, Uitterlinden, A G, Ulloor, J, Viikari, J, Volker, U, Volzke, H, Wichmann, H E, Wu, T S, Zhuang, W V, Ziv, E, Wu, F C W, Raitakari, O, Eriksson, A, Bidlingmaier, M, Harris, T B, Murray, A, de Jong, F H, Murabito, J M, Bhasin, S, Vandenput, L & Haring, R 2011, ' Genetic determinants of serum testosterone concentrations in men ', PLoS Genetics, vol. 7, no. 10, e1002313 . https://doi.org/10.1371/journal.pgen.1002313
PLoS Genetics, 7(10):e1002313. Public Library of Science
PLoS Genetics; Vol 7
PLoS Genetics (print), 7(10). Public Library of Science
PLoS Genetics
PLoS Genetics; 7(10) (2011)
PLoS Genetics, Vol 7, Iss 10, p e1002313 (2011)

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdead66697221334c950ba268251011b
https://acuresearchbank.acu.edu.au/item/89qz6/genetic-determinants-of-serum-testosterone-concentrations-in-men