ASC-J9 Blocks Cell Proliferation and Extracellular Matrix Production of Keloid Fibroblasts through Inhibiting STAT3 Signaling

Autor: Yi-Kai Hong, Chen-Han Wu, Yu-Chen Lin, Yu-Lun Huang, Kuo-Shu Hung, Tsung-Pin Pai, Yen-Ting Liu, Tzu-Chi Chen, Hardy Chan, Chao-Kai Hsu

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5549 (2022)

Keloids are a fibrotic skin disorder caused by abnormal wound healing and featuring the activation and expansion of fibroblasts beyond the original wound margin. Signal transducer and activator of transcription 3 (STAT3) has been found to mediate the

Externí odkaz: https://doaj.org/article/80d958102ebc49d691443db1429ab678

The HUSH complex controls brain architecture and protocadherin fidelity

Autor: Maria Novatchkova, Meritxell Balmaña, Shane J. F. Cronin, Anoop Kavirayani, Astrid Hagelkruys, Domagoj Cikes, Josef M. Penninger, Michael Orthofer, Christopher Esk, Juergen A. Knoblich, Rubina Koglgruber, Sergei Zhuk, Ulrich Elling, Tsung-Pin Pai, Marion Horrer, Jasmin Taubenschmid-Stowers

Fine-tuning of neural connectivity is important for cerebral functions and brain evolution. Protocadherins provide barcodes for neuronal identity as well as synapse formation and expansion of protocadherin cluster genes has been linked to advanced co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9225e6361d2febef1aeb1ee67e280e5
https://doi.org/10.1101/2021.11.29.466909

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy

Autor: Yin Zhang, Judit Berta, Balazs Dome, Rezaul Karim, Jelena Lazovic, Viktoria Laszlo, Keiji Kuba, Lisa Haas, Luigi Tortola, Sumit Deswal, Miklós Szűcs, Josef M. Penninger, Reiner A. Wimmer, Bernhard J. Haubner, Iris Uribesalgo, Yihai Cao, David Hoffmann, Anoop Kavirayani, Daniel Schramek, Johannes Zuber, Maria Novatchkova, Tsung-Pin Pai

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 8, Pp n/a-n/a (2019)

Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01a3c45748b21d7b41ed58900045355
https://doaj.org/article/c9219521219c4174a4bfd4db4a736fc6

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

Autor: Berge, Nathalie Ariane E van den, Ferreira, Nelson, Mikkelsen, Trine Werenberg, Alstrup, Aage Kristian Olsen, Casadei, Nicolas, Tsung-Pin, Pai, Riess, Olaf, Nyengaard, Jens Randel, Tamgüney, Gültekin, Jensen, Poul Henning, Borghammer, Per

Publikováno v: Berge, N A E V D, Ferreira, N, Mikkelsen, T W, Alstrup, A K O, Casadei, N, Tsung-Pin, P, Riess, O, Nyengaard, J R, Tamgüney, G, Jensen, P H & Borghammer, P 2019, ' Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats ' Acta Neuropathologica .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::389ce4ad1790463627dfefc5171aefa1
https://pure.au.dk/portal/da/publications/evidence-for-bidirectional-and-transsynaptic-parasympathetic-and-sympathetic-propagation-of-alphasynuclein-in-rats(48d47ca7-bbdb-40ea-a8c3-ca14d36f86d8).html

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