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Akademický článek
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Autor:
Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 896-907 (2021)
Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxic
Externí odkaz:
https://doaj.org/article/15f8b06964f947a390606a8fa34d62cd
Publikováno v:
Toxics, Vol 8, Iss 4, p 106 (2020)
Organophosphorus compound exposure remains a present threat through agricultural accidents, warfare, or terrorist activity. The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current emer
Externí odkaz:
https://doaj.org/article/6cf663c10ed04be9be55cf2c65431ee4
Autor:
Tsung-Ming Shih
Publikováno v:
Toxicology and Applied Pharmacology. 464:116437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b65aa3cb58edb41ca2bb165eaf4d7a95
https://doi.org/10.1016/j.taap.2023.116437
https://doi.org/10.1016/j.taap.2023.116437
Autor:
Katie Walker, Linnzi K.M. Wright, Tsung-Ming Shih, Fu Du, Michael F. Stone, Zora-Maya Keith, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Kimberly A. Whitten, Cindy Acon-Chen
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 896-907 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757661aa0cf9bbfbadc91ef4471049fd
http://www.sciencedirect.com/science/article/pii/S2214750021000810
http://www.sciencedirect.com/science/article/pii/S2214750021000810
Publikováno v:
Neurotoxicity Research. 36:323-333
Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase, which results in the accumulation of acetylcholine and widespread excitotoxic seizure activity. Because current medical countermeasures (anticholinergics, AChE reactivator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32e6c20082b90bc495ea3042e5464c3
https://doi.org/10.1007/s12640-019-00034-w
https://doi.org/10.1007/s12640-019-00034-w
Publikováno v:
Toxicology Mechanisms and Methods. 29:322-333
The efficacy of anticonvulsant therapies to stop seizure activities following organophosphorus nerve agents (NAs) has been documented as being time-dependent. We utilized the guinea pig NA-seizure model to compare the effectiveness of phencynonate (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c8f02e0a604f9b93fd1217b8a42963
https://doi.org/10.1080/15376516.2018.1558322
https://doi.org/10.1080/15376516.2018.1558322
Publikováno v:
Computational Biology and Chemistry. 75:74-81
Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). The over accumulation of ACh after NA exposure leads to cholinergic toxicity, sei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d48b90121bec32369c93186f5fce7e7
https://doi.org/10.1016/j.compbiolchem.2018.04.017
https://doi.org/10.1016/j.compbiolchem.2018.04.017
Autor:
Thaddeus P Thomas, Tsung-Ming Shih
Publikováno v:
Biomedical Journal of Scientific & Technical Research. 17
Nerve agents (NAs) induce a cholinergic crisis by inhibiting acetylcholinesterase (AChE) throughout the nervous system. While current medical countermeasures effectively mitigate peripheral effects, the brain is vulnerable to severe damage as sustain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050b2f943e0c2bd5d0bbef86af36b499
https://doi.org/10.26717/bjstr.2019.17.003074
https://doi.org/10.26717/bjstr.2019.17.003074
Publikováno v:
Toxicology and Applied Pharmacology. 416:115466
Soman, an organophosphorus (OP) compound, disrupts nervous system function through inactivation of acetylcholinesterase (AChE), the enzyme that breaks down acetylcholine at synapses. Left untreated, a state of prolonged seizure activity (status epile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd204c3eb2c70a48ed6ad304271c73c
https://doi.org/10.1016/j.taap.2021.115466
https://doi.org/10.1016/j.taap.2021.115466