Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Tsuneyuki Sugiura"'
1
Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF1) receptor antagonists
Autor: Akihiro Kishi, Tetsuo Obitsu, Chiaki Minamoto, Tetsuji Saito, Sonoko Ueno, Hisao Nakai, Naoya Matsumura, Seishi Katsumata, Tsuneyuki Sugiura, Masaaki Toda
Publikováno v: Bioorganic & Medicinal Chemistry. 19:5955-5966
To identify structurally novel CRF1 receptor antagonists, a series of bicyclic core antagonists, pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines, imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines were designed, synthesized and eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e19d53db15b326b440a61e1ee982c7
https://doi.org/10.1016/j.bmc.2011.08.055
Zobrazit plný text záznamu
2
Design and synthesis of novel metalloproteinase inhibitors
Autor: Masahiro Ikura, Tsuneyuki Sugiura, Shingo Nakatani, Shingo Yamamoto, Satoshi Itadani, Hiroyuki Ohno, Yoshitaka Nishita, Hiromu Habashita, Masaaki Toda, Kanji Takahashi, Koji Ogawa, Hisao Nakai
Publikováno v: Bioorganic & Medicinal Chemistry. 14:5402-5422
A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551385e62e39b48e1a4bcf1c126af91e
https://doi.org/10.1016/j.bmc.2006.03.032
Zobrazit plný text záznamu
3
Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF₁) receptor antagonists
Autor: Tetsuji, Saito, Tetsuo, Obitsu, Chiaki, Minamoto, Tsuneyuki, Sugiura, Naoya, Matsumura, Sonoko, Ueno, Akihiro, Kishi, Seishi, Katsumata, Hisao, Nakai, Masaaki, Toda
Publikováno v: Bioorganicmedicinal chemistry. 19(20)
To identify structurally novel CRF1 receptor antagonists, a series of bicyclic core antagonists, pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines, imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines were designed, synthesized and eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cfbfd92f63a22fa0e861861db6c25dc
https://pubmed.ncbi.nlm.nih.gov/21930387
Zobrazit plný text záznamu
4
Design and synthesis of an orally active matrix metalloproteinase inhibitor
Autor: Shingo Nakatani, Hisao Nakai, Satoshi Itadani, Masaaki Toda, Masahiro Ikura, Kanji Takahashi, Yoshitaka Nishita, Tsuneyuki Sugiura, Shingo Yamamoto, Koji Ogawa, Hiroyuki Ohno
Publikováno v: Bioorganicmedicinal chemistry. 14(18)
A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in exhibited strong
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1442ff38d5581d18026a2c7b56c3e38
https://pubmed.ncbi.nlm.nih.gov/16765051
Zobrazit plný text záznamu
5
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor
Autor: Koji Ogawa, Hisao Nakai, Hiromu Habashita, Masaaki Toda, Tsuneyuki Sugiura, Shingo Yamamoto, Masahiro Ikura, Kanji Takahashi, Hiroyuki Ohno, Shingo Nakatani
Publikováno v: Bioorganicmedicinal chemistry. 14(12)
A series of N-benzoyl gamma-aminobutyric hydroxamic acids were synthesized and evaluated as matrix metalloproteinase inhibitors. First, we focused on chemical modification of the N-benzoyl residue. Introduction of electron-rich para-substituents was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a1dec8b1be595f5e91efadfea3ad40
https://pubmed.ncbi.nlm.nih.gov/16481176
Zobrazit plný text záznamu
6
Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach
Autor: Minoru Nishizaki, Koji Ogawa, Masahiro Ikura, Hiromu Habashita, Hiroyuki Ohno, Kanji Takahashi, Tsuneyuki Sugiura, Hisao Nakai, Masaaki Toda, Shingo Yamamoto, Shingo Nakatani
Publikováno v: Bioorganicmedicinal chemistry. 13(14)
Generation of structurally new matrix metalloproteinase inhibitors was successfully carried out using an in silico technique. In order to identify the small fragment interacting with residues in the S1′ pocket of MMP-1 through hydrogen bonds, we pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70c5eba075ba524fbd37bf09c222e45
https://pubmed.ncbi.nlm.nih.gov/15908222
Zobrazit plný text záznamu
8
A facile synthesis of ulicyclamide
Autor: Takayuki Shioiri, Yasumasa Hamada, Tsuneyuki Sugiura
Publikováno v: Tetrahedron Letters. 28:2251-2254
Ulicyclamide ( 1 ), a cytotoxic cyclic peptide from a marine tunicate, has been efficiently synthesized by the solid-phase method using diethyl phosphorocyanidate for the coupling and trimethylsilyl triflate for the final deprotection.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa2da416dd4dc2060fc8bbb7b7ccac40
https://doi.org/10.1016/s0040-4039(00)96093-3
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje