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MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
Autor:
Sakamoto, Katsumi, Tominaga, Yohei, Yamauchi, Kazumi, Nakatsu, Yoshimichi, Sakumi, Kunihiko, Yoshiyama, Kaoru, Egashira, Akinori, Kura, Shinobu, Yao, Takashi, Tsuneyoshi, Masasumi, Maki, Hisaji, Nakabeppu, Yusaku, Tsuzuki, Teruhisa
Publikováno v:
Cancer Research. 67(14):6599-6604
MUTYH is a mammalian DNA glycosylase that initiates base excision repair by excising adenine opposite 8-oxoguanine and 2-hydroxyadenine opposite guanine, thereby preventing G:C to T:A transversion caused by oxidative stress. Recently, biallelic germ-